RLG00000005458

Down syndrome critical region protein

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_laevigata
Chr1
OG0002255
Physical Location & Seq
Forward (+)
67823169 .. 67825470
2302 bp
Loading structure...
UTR
Exon/CDS
Intron
RLM00000005458

Sequence Viewer

Length: 894 bp
ATGTCGATTGAGCTCAAGCTTTCCCGGATTAATCGAGTTTATCGTCCTTCTGAACTGGTTGAGGGCAAGATCACCGTGAAGTCTTCGTCTTCAATCTCGCACTATGGAATTCGCATCGCGGTTGATGGATCTGTCAACTTGCAGGTTCGGGGAGGGACGGCCGGAGTTATAGAGACTTTGGTTGGTGCTGCCAAGCCTATTTCTATTCTGAACAAAATTGTTGAGCTTAGACCTGCTGGAAAGATTGCTTCAGGCCTAACCGAGACGTTCCATGGAGGAAATATTAACATTCAGTATTTAGTGACTGTAGATATATCGAGAGGATACCTGTATAAGTCATTATCCACAACAATGGAGTTCATAGTTGAAAGTGATAAAGCTGATGTAATTGAGCGACCAGTTTCTCCGGAGATGGTTGTCTTTTACATTACTCAGGATACCCAAAGACATCCGCTACTTCCTCAACTGAAATCAGGTGGATTTCGAATTATTGGAAAATTGGCCACTCAATGTTCTTTATCAGATCCCGTTAGTGGTGAACTAACGGTAGAAACATCTGCAGTTCCAATTTCTTCCATTGATATGCACTTGCTTCGTGTAGAGTCGATCCTTCTAGGGGAGAAAATTGTGACTGAGAAGTCTCTGGTTCAGACTACACAGTTAGCAGATGGAGACGTCTGTCATAATATGACTCTGCCCATTCATGTTATACTTCCCCGTCTTTTGACATGTCCTACAGTCTCAGCAGGGCCATTCTCGATTGAATTTAAAGTTGTCATAGTCATAACATTTCAGTCAGAGGTAGCCAAATTGCATTCAAAATCTGATCCTACAACTCCCAGACTATGGCTTGCAATGGAGACTCTACCGCTTGAACTTGTTAGAACAAGGTAA

Protein Analysis

298

Amino Acids

32.45

Weight (kDa)

7.75

Isoelectric Point (pI)

42.52

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Vps26 PF03643 11 - 263 4.6e-22 Vacuolar protein sorting-associated protein 26
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

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Publication-ready
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AasI GACNNNNNNGTC 1 cut(s) 637
AatII GACGTC 1 cut(s) 678
Acc36I ACCTGC 2 cut(s) 133, 241
AccB7I CCANNNNNTGG 1 cut(s) 846
AccII CGCG 1 cut(s) 119
AccIII TCCGGA 1 cut(s) 406
AciI CCGC 3 cut(s) 119, 452, 869
AclWI GGATC 4 cut(s) 136, 518, 601, 821
AcoI YGGCCR 2 cut(s) 159, 501
AcsI RAATTY 2 cut(s) 108, 764
AcuI CTGAAG 1 cut(s) 234
AcyI GRCGYC 1 cut(s) 675
AfiI CCNNNNNNNGG 3 cut(s) 533, 616, 846
AflIII ACRYGT 1 cut(s) 728
AgsI TTSAA 5 cut(s) 93, 368, 764, 819, 875
AluBI AGCT 4 cut(s) 13, 19, 226, 380
AluI AGCT 4 cut(s) 13, 19, 226, 380
Alw21I GWGCWC 1 cut(s) 15
Alw26I GTCTC 6 cut(s) 167, 257, 645, 666, 745, 854
AlwI GGATC 4 cut(s) 136, 518, 601, 821
Aor13HI TCCGGA 1 cut(s) 406
AoxI GGCC 4 cut(s) 159, 253, 501, 749
ApeKI GCWGC 1 cut(s) 188
ApoI RAATTY 2 cut(s) 108, 764
AseI ATTAAT 1 cut(s) 30
AspS9I GGNCC 1 cut(s) 749
AsuC2I CCSGG 1 cut(s) 25
AsuHPI GGTGA 2 cut(s) 64, 548
AsuII TTCGAA 1 cut(s) 484
BalI TGGCCA 1 cut(s) 503
BanII GRGCYC 1 cut(s) 15
BbsI GAAGAC 2 cut(s) 75, 81
Bbv12I GWGCWC 1 cut(s) 15
BbvI GCAGC 1 cut(s) 175
BccI CCATC 3 cut(s) 119, 406, 662
BceAI ACGGC 1 cut(s) 174
BcgI CGANNNNNNTGC 2 cut(s) 575, 609
BciVI GTATCC 2 cut(s) 317, 430
BcnI CCSGG 1 cut(s) 25
BcoDI GTCTC 6 cut(s) 167, 257, 645, 666, 745, 854
BfaI CTAG 1 cut(s) 614
BfmI CTRYAG 3 cut(s) 306, 558, 735
BfuAI ACCTGC 2 cut(s) 133, 241
BfuI GTATCC 2 cut(s) 317, 430
BisI GCNGC 1 cut(s) 189
BlsI GCNGC 1 cut(s) 190
Bme1390I CCNGG 1 cut(s) 25
BmgT120I GGNCC 1 cut(s) 749
BmrFI CCNGG 1 cut(s) 25
BmsI GCATC 1 cut(s) 123
BoxI GACNNNNGTC 1 cut(s) 678
BpiI GAAGAC 2 cut(s) 75, 81
Bpu14I TTCGAA 1 cut(s) 484
BpuMI CCSGG 1 cut(s) 25
BsaHI GRCGYC 1 cut(s) 675
BsaJI CCNNGG 1 cut(s) 271
BsaWI WCCGGW 1 cut(s) 406
Bsc4I CCNNNNNNNGG 3 cut(s) 533, 616, 846
Bse1I ACTGG 2 cut(s) 60, 398
Bse3DI GCAATG 1 cut(s) 861
BseAI TCCGGA 1 cut(s) 406
BseDI CCNNGG 1 cut(s) 271
BseGI GGATG 1 cut(s) 448
BseLI CCNNNNNNNGG 3 cut(s) 533, 616, 846
BseMI GCAATG 1 cut(s) 861
BseMII CTCAG 3 cut(s) 446, 624, 756
BseNI ACTGG 2 cut(s) 60, 398
BseX3I CGGCCG 1 cut(s) 159
BseXI GCAGC 1 cut(s) 175
Bsh1236I CGCG 1 cut(s) 119
Bsh1285I CGRYCG 1 cut(s) 162
BshFI GGCC 4 cut(s) 161, 255, 503, 751
BsiEI CGRYCG 1 cut(s) 162
BsiHKAI GWGCWC 1 cut(s) 15
BsiSI CCGG 3 cut(s) 25, 162, 407
BslFI GGGAC 1 cut(s) 169
BslI CCNNNNNNNGG 3 cut(s) 533, 616, 846
BsmAI GTCTC 6 cut(s) 167, 257, 645, 666, 745, 854
BsmBI CGTCTC 2 cut(s) 257, 666
BsmFI GGGAC 1 cut(s) 169
BsmI GAATGC 1 cut(s) 814
BsnI GGCC 4 cut(s) 161, 255, 503, 751
Bsp119I TTCGAA 1 cut(s) 484
Bsp1286I GDGCHC 1 cut(s) 15
Bsp13I TCCGGA 1 cut(s) 406
Bsp143I GATC 5 cut(s) 69, 128, 523, 606, 826
Bsp19I CCATGG 1 cut(s) 271
BspACI CCGC 3 cut(s) 119, 452, 869
BspANI GGCC 4 cut(s) 161, 255, 503, 751
BspCNI CTCAG 3 cut(s) 445, 625, 755
BspEI TCCGGA 1 cut(s) 406
BspFNI CGCG 1 cut(s) 119
BspMAI CTGCAG 1 cut(s) 562
BspMI ACCTGC 2 cut(s) 133, 241
BspPI GGATC 4 cut(s) 136, 518, 601, 821
BspT104I TTCGAA 1 cut(s) 484
BsrDI GCAATG 1 cut(s) 861
BsrI ACTGG 2 cut(s) 60, 398
BssECI CCNNGG 1 cut(s) 271
BssMI GATC 5 cut(s) 69, 128, 523, 606, 826
BssNI GRCGYC 1 cut(s) 675
BssT1I CCWWGG 1 cut(s) 271
Bst4CI ACNGT 5 cut(s) 76, 307, 547, 660, 739
BstACI GRCGYC 1 cut(s) 675
BstBI TTCGAA 1 cut(s) 484
BstC8I GCNNGC 1 cut(s) 852
BstDEI CTNAG 4 cut(s) 227, 432, 633, 742
BstDSI CCRYGG 1 cut(s) 271
BstF5I GGATG 1 cut(s) 448
BstFNI CGCG 1 cut(s) 119
BstKTI GATC 5 cut(s) 72, 131, 526, 609, 829
BstMAI GTCTC 6 cut(s) 167, 257, 645, 666, 745, 854
BstMBI GATC 5 cut(s) 69, 128, 523, 606, 826
BstMCI CGRYCG 1 cut(s) 162
BstNSI RCATGY 1 cut(s) 732
BstPAI GACNNNNGTC 1 cut(s) 678
BstSCI CCNGG 1 cut(s) 23
BstSFI CTRYAG 3 cut(s) 306, 558, 735
BstUI CGCG 1 cut(s) 119
BstV1I GCAGC 1 cut(s) 175
BstV2I GAAGAC 2 cut(s) 75, 81
BstX2I RGATCY 2 cut(s) 128, 523
BstXI CCANNNNNNTGG 1 cut(s) 352
BstYI RGATCY 2 cut(s) 128, 523
BstZI CGGCCG 1 cut(s) 159
BsuI GTATCC 2 cut(s) 317, 430
BsuRI GGCC 4 cut(s) 161, 255, 503, 751
BtgI CCRYGG 1 cut(s) 271
BtgZI GCGATG 1 cut(s) 100
BtsCI GGATG 1 cut(s) 448
BveI ACCTGC 2 cut(s) 133, 241
Cac8I GCNNGC 1 cut(s) 852
Cfr13I GGNCC 1 cut(s) 749
CviAII CATG 3 cut(s) 272, 704, 729
DdeI CTNAG 4 cut(s) 227, 432, 633, 742
DpnI GATC 5 cut(s) 71, 130, 525, 608, 828
DpnII GATC 5 cut(s) 69, 128, 523, 606, 826
DraI TTTAAA 1 cut(s) 769
DrdI GACNNNNNNGTC 1 cut(s) 637
DseDI GACNNNNNNGTC 1 cut(s) 637
EaeI YGGCCR 2 cut(s) 159, 501
EagI CGGCCG 1 cut(s) 159
Ecl136II GAGCTC 1 cut(s) 13
EclXI CGGCCG 1 cut(s) 159
Eco130I CCWWGG 1 cut(s) 271
Eco147I AGGCCT 1 cut(s) 255
Eco24I GRGCYC 1 cut(s) 15
Eco52I CGGCCG 1 cut(s) 159
Eco53kI GAGCTC 1 cut(s) 13
Eco57I CTGAAG 1 cut(s) 234
EcoICRI GAGCTC 1 cut(s) 13
EcoRI GAATTC 1 cut(s) 108
EcoT14I CCWWGG 1 cut(s) 271
EcoT38I GRGCYC 1 cut(s) 15
ErhI CCWWGG 1 cut(s) 271
Esp3I CGTCTC 2 cut(s) 257, 666
FaeI CATG 3 cut(s) 275, 707, 732
FaqI GGGAC 1 cut(s) 169
FatI CATG 3 cut(s) 271, 703, 728
Fnu4HI GCNGC 1 cut(s) 189
FokI GGATG 1 cut(s) 435
FriOI GRGCYC 1 cut(s) 15
Fsp4HI GCNGC 1 cut(s) 189
FspBI CTAG 1 cut(s) 614
GluI GCNGC 1 cut(s) 189
HaeIII GGCC 4 cut(s) 161, 255, 503, 751
HapII CCGG 3 cut(s) 25, 162, 407
Hin1I GRCGYC 1 cut(s) 675
Hin1II CATG 3 cut(s) 275, 707, 732
HincII GTYRAC 1 cut(s) 136
HindII GTYRAC 1 cut(s) 136
HindIII AAGCTT 1 cut(s) 17
HinfI GANTC 3 cut(s) 602, 691, 862
HpaII CCGG 3 cut(s) 25, 162, 407
HphI GGTGA 2 cut(s) 64, 548
Hpy166II GTNNAC 2 cut(s) 136, 539
Hpy188I TCNGA 6 cut(s) 52, 210, 523, 651, 799, 826
Hpy188III TCNNGA 4 cut(s) 318, 407, 434, 757
Hpy8I GTNNAC 2 cut(s) 136, 539
HpyAV CCTTC 2 cut(s) 57, 620
HpyCH4III ACNGT 5 cut(s) 76, 307, 547, 660, 739
HpyCH4IV ACGT 2 cut(s) 266, 675
HpyCH4V TGCA 5 cut(s) 142, 560, 586, 814, 854
HpyF3I CTNAG 4 cut(s) 227, 432, 633, 742
HpySE526I ACGT 2 cut(s) 266, 675
Hsp92I GRCGYC 1 cut(s) 675
Hsp92II CATG 3 cut(s) 275, 707, 732
Kpn2I TCCGGA 1 cut(s) 406
Kzo9I GATC 5 cut(s) 69, 128, 523, 606, 826
Lsp1109I GCAGC 1 cut(s) 175
LweI GCATC 1 cut(s) 123
MaeI CTAG 1 cut(s) 614
MaeII ACGT 2 cut(s) 266, 675
MaeIII GTNAC 2 cut(s) 301, 628
MalI GATC 5 cut(s) 71, 130, 525, 608, 828
MboI GATC 5 cut(s) 69, 128, 523, 606, 826
MboII GAAGA 3 cut(s) 75, 81, 564
MflI RGATCY 2 cut(s) 128, 523
MhlI GDGCHC 1 cut(s) 15
MlsI TGGCCA 1 cut(s) 503
MluCI AATT 9 cut(s) 108, 216, 387, 486, 497, 567, 624, 764, 809
MluNI TGGCCA 1 cut(s) 503
MlyI GAGTC 3 cut(s) 611, 685, 856
MnlI CCTC 6 cut(s) 55, 146, 269, 314, 471, 793
Mox20I TGGCCA 1 cut(s) 503
MroI TCCGGA 1 cut(s) 406
MscI TGGCCA 1 cut(s) 503
MseI TTAA 3 cut(s) 30, 285, 768
MslI CAYNNNNRTG 2 cut(s) 350, 581
Msp20I TGGCCA 1 cut(s) 503
MspI CCGG 3 cut(s) 25, 162, 407
MspR9I CCNGG 1 cut(s) 25
Mva1269I GAATGC 1 cut(s) 814
MvnI CGCG 1 cut(s) 119
NciI CCSGG 1 cut(s) 25
NcoI CCATGG 1 cut(s) 271
NdeII GATC 5 cut(s) 69, 128, 523, 606, 826
NlaIII CATG 3 cut(s) 275, 707, 732
NmuCI GTSAC 2 cut(s) 301, 628
NspI RCATGY 1 cut(s) 732
NspV TTCGAA 1 cut(s) 484
PceI AGGCCT 1 cut(s) 255
PciI ACATGT 1 cut(s) 728
PcsI WCGNNNNNNNCGW 1 cut(s) 40
PctI GAATGC 1 cut(s) 814
PflMI CCANNNNNTGG 1 cut(s) 846
PfoI TCCNGGA 1 cut(s) 23
PkrI GCNGC 1 cut(s) 190
PleI GAGTC 3 cut(s) 610, 685, 856
PpsI GAGTC 3 cut(s) 610, 685, 856
PscI ACATGT 1 cut(s) 728
PshAI GACNNNNGTC 1 cut(s) 678
PshBI ATTAAT 1 cut(s) 30
Psp124BI GAGCTC 1 cut(s) 15
PspPI GGNCC 1 cut(s) 749
PstI CTGCAG 1 cut(s) 562
PsuI RGATCY 2 cut(s) 128, 523
RseI CAYNNNNRTG 2 cut(s) 350, 581
SacI GAGCTC 1 cut(s) 15
SaqAI TTAA 3 cut(s) 30, 285, 768
SatI GCNGC 1 cut(s) 189
Sau3AI GATC 5 cut(s) 69, 128, 523, 606, 826
Sau96I GGNCC 1 cut(s) 749
SchI GAGTC 3 cut(s) 611, 685, 856
ScrFI CCNGG 1 cut(s) 25
SduI GDGCHC 1 cut(s) 15
SfaNI GCATC 1 cut(s) 123
SfcI CTRYAG 3 cut(s) 306, 558, 735
SfuI TTCGAA 1 cut(s) 484
SmiMI CAYNNNNRTG 2 cut(s) 350, 581
SmlI CTYRAG 1 cut(s) 14
SmoI CTYRAG 1 cut(s) 14
Sse9I AATT 9 cut(s) 108, 216, 387, 486, 497, 567, 624, 764, 809
SseBI AGGCCT 1 cut(s) 255
SsiI CCGC 3 cut(s) 119, 452, 869
SspI AATATT 1 cut(s) 283
SspMI CTAG 1 cut(s) 614
SstI GAGCTC 1 cut(s) 15
StuI AGGCCT 1 cut(s) 255
StyD4I CCNGG 1 cut(s) 23
StyI CCWWGG 1 cut(s) 271
TaaI ACNGT 5 cut(s) 76, 307, 547, 660, 739
TaiI ACGT 2 cut(s) 269, 678
TaqI TCGA 6 cut(s) 5, 34, 317, 484, 605, 758
TasI AATT 9 cut(s) 108, 216, 387, 486, 497, 567, 624, 764, 809
Tru1I TTAA 3 cut(s) 30, 285, 768
Tru9I TTAA 3 cut(s) 30, 285, 768
TseFI GTSAC 2 cut(s) 301, 628
TseI GCWGC 1 cut(s) 188
Tsp45I GTSAC 2 cut(s) 301, 628
TspDTI ATGAA 2 cut(s) 349, 692
Van91I CCANNNNNTGG 1 cut(s) 846
VspI ATTAAT 1 cut(s) 30
XapI RAATTY 2 cut(s) 108, 764
XceI RCATGY 1 cut(s) 732
XspI CTAG 1 cut(s) 614
ZraI GACGTC 1 cut(s) 676
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.