RchiOBHm_Chr2g0084851

Belongs to the UDP-glycosyltransferase family

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_chinensis
2
OG0001004
Physical Location & Seq
Reverse (-)
490939 .. 492911
1973 bp
Loading structure...
UTR
Exon/CDS
Intron
N/A

Sequence Viewer

Length: 1527 bp
ATGGAGAGGGAATGTGAAACAATATCTGCTGCTCCACCTGAGATCCTAGTATTCCCATTTCCTGGTCAGGGCCATATGTGCCCAATGGTTCAGTTCTCCAAGCGACTTGCCTCTAAAGGTCTTAGAGTCACAGTCGTTTCAACCATCTCTGCTGCCAAGTCTATTCAGCAAAGTCCGGCCCATGCCCAAGCTTTCCAAGTAGAATTCATTTCGGACGGTTCCAAAGAAGAAAACAAGTCTGAAACTTTGGACGAAGCTATTGAGCGTTTCAAAAAGGCAACTACACAAACTCTAACCGAACTTATCATCAACATCCAGAACAAGAACACCACTACTACTATCTGTACTAGCAATGGTGATCATGCCTCCTCGGTGGAACAGGTTCCACCCAAGCTCAAGCTCAAGCTCCTGATTTACGACTCAGGGATGCCGTGGGTTTTGGATATAGCGCGACAACAAGGCATAGAAGGAGCTCCTTTTTTTACACAGTCATGCGCGATTGCATCCGTCTACTATCACTTCCGTGAAGGGGCATGTAAGATAATTACTACTGCTCCCACCTCTGGTTTAGATGACGACTCAGAAGCTGCTAATCATGGAAGATCATCACCGTCTACCGACACAATATTATTGCCGGCTATGCCACCACTTGGAGTCAATGACTTACCATCTTTTCTATGTGATACTCATTCCTATCCAGTTTTATGTAAACATACCCTGAATCAATTCTCCAATTTCCGGGAAGCAAAATGGCAATTGTACAACACTTTTGATACGTTAGAACATGAGGTAGTCAAATGGATGACAAGTCAGTCTTGGGCAGTGAAGACAGTAGGACCAACAATTCCGTCAATGTTTCTGGACAAGCGATTTGAAGATGACAAAGACTACAGTTTCAACCTCTTCGAGCCTGTGGAGACTTACTTGAAGTGGCTTGACTCCAAGGAAACTGGCTCAGTGGTTTATGCATCATTTGGAAGCTACGGTAGCCTAGAAAAAAAGCAAATGGAGGAAATAGCTTGGGGTCTGAAGAACAGCAACTACCACTTCTTGTGGGTAGTCAGAGAATTAGAGAAGGAGAAGCTTCCGAAGAATTTCATAAAGGAGGTATTAGATTCAGCTGATCAGAAAGGTCTTGTCGTGAGCTGGTGCTCGCAGCTGCGAGTCTTGGCTCACAAGGCCTTAGGATGCTTTGTTACTCACTGCGGATGGAATTCGACCCTTGAAGCTTTGAGCTTAGGGGCCCCGATGGTGGCAATGCCGCAATGGACTGATCAAACAACAAACGCCAAGTTTGTTCAGGATGTGTGGAAAGCAGGAGTTAGAGTGAGAGTGGATGAGAAATTAGGTGTTACAACAAAAGAAGAGATAGCTAACTGTATTAGGCAAGTCATGGAAGAGGAAAAAGGGGTGGAGATCAGAAAGGCTTTATCAAATTGGAAGCAATTGGCTAAAGAGGCAGTCAACCAAGGGGGAAGCTCCGATCAAAATATTGAGGAGTTTGTGGCACAACTTCTGTTAATTTGA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
No ontology terms assigned.
KEGG Pathways
Metabolic & Signaling
ko00380 ko00966 ko01110 ko01210 map00380 map00966 map01110 map01210
Pfam Domains
Protein Families
UDPGT

Protein Analysis

508

Amino Acids

56.88

Weight (kDa)

5.6

Isoelectric Point (pI)

44.94

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
UDPGT PF00201 313 - 468 3.4e-24 UDP-glucoronosyl and UDP-glucosyl transferase
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AasI GACNNNNNNGTC 1 cut(s) 811
AccB7I CCANNNNNTGG 2 cut(s) 62, 650
AccI GTMKAC 2 cut(s) 510, 614
AccII CGCG 2 cut(s) 451, 497
AciI CCGC 2 cut(s) 1206, 1262
AclWI GGATC 1 cut(s) 37
AcsI RAATTY 3 cut(s) 203, 1093, 1213
AcuI CTGAAG 1 cut(s) 1049
AfaI GTAC 2 cut(s) 346, 761
AfiI CCNNNNNNNGG 7 cut(s) 62, 68, 529, 563, 650, 738, 1252
AgsI TTSAA 6 cut(s) 141, 271, 875, 898, 928, 1226
AjnI CCWGG 1 cut(s) 61
AleI CACNNNNGTG 1 cut(s) 522
Alw21I GWGCWC 2 cut(s) 475, 1154
Alw26I GTCTC 1 cut(s) 911
AlwI GGATC 1 cut(s) 37
AlwNI CAGNNNCTG 1 cut(s) 587
AoxI GGCC 4 cut(s) 70, 177, 1179, 1242
ApaI GGGCCC 1 cut(s) 1246
ApeKI GCWGC 5 cut(s) 29, 152, 587, 1156, 1159
ApoI RAATTY 3 cut(s) 203, 1093, 1213
ArsI GACNNNNNNTTYG 2 cut(s) 854, 886
Asp700I GAANNNNTTC 3 cut(s) 381, 725, 1094
AspLEI GCGC 2 cut(s) 451, 497
AspS9I GGNCC 5 cut(s) 70, 178, 836, 1242, 1243
AsuC2I CCSGG 1 cut(s) 740
AsuHPI GGTGA 2 cut(s) 368, 600
AvaII GGWCC 1 cut(s) 836
AxyI CCTNAGG 1 cut(s) 1183
BaeGI GKGCMC 2 cut(s) 83, 1246
BanII GRGCYC 2 cut(s) 475, 1246
BbsI GAAGAC 1 cut(s) 833
Bbv12I GWGCWC 2 cut(s) 475, 1154
BbvI GCAGC 5 cut(s) 16, 139, 574, 1146, 1168
BccI CCATC 4 cut(s) 152, 676, 1203, 1243
BceAI ACGGC 1 cut(s) 415
BciT130I CCWGG 1 cut(s) 63
BclI TGATCA 3 cut(s) 358, 1123, 1273
BcnI CCSGG 1 cut(s) 740
BcoDI GTCTC 1 cut(s) 911
BfaI CTAG 3 cut(s) 47, 348, 992
BfmI CTRYAG 1 cut(s) 889
BisI GCNGC 6 cut(s) 30, 153, 588, 1157, 1160, 1262
BlsI GCNGC 6 cut(s) 31, 154, 589, 1158, 1161, 1263
Bme1390I CCNGG 2 cut(s) 63, 740
Bme18I GGWCC 1 cut(s) 836
BmgT120I GGNCC 5 cut(s) 70, 178, 836, 1242, 1243
BmiI GGNNCC 5 cut(s) 220, 384, 1243, 1244, 1245
BmrFI CCNGG 2 cut(s) 63, 740
BmsI GCATC 4 cut(s) 417, 512, 977, 1178
BpiI GAAGAC 1 cut(s) 833
Bpu10I CCTNAGC 1 cut(s) 1237
BpuEI CTTGAG 2 cut(s) 380, 386
BpuMI CCSGG 1 cut(s) 740
BsaJI CCNNGG 4 cut(s) 369, 431, 942, 1468
BsaXI ACNNNNNCTCC 4 cut(s) 538, 568, 1311, 1341
Bsc4I CCNNNNNNNGG 7 cut(s) 62, 68, 529, 563, 650, 738, 1252
Bse118I RCCGGY 1 cut(s) 634
Bse1I ACTGG 2 cut(s) 698, 955
Bse21I CCTNAGG 1 cut(s) 1183
Bse3DI GCAATG 3 cut(s) 358, 1263, 1271
BseBI CCWGG 1 cut(s) 63
BseDI CCNNGG 4 cut(s) 369, 431, 942, 1468
BseGI GGATG 8 cut(s) 312, 432, 503, 807, 1193, 1214, 1309, 1342
BseLI CCNNNNNNNGG 7 cut(s) 62, 68, 529, 563, 650, 738, 1252
BseMI GCAATG 3 cut(s) 358, 1263, 1271
BseMII CTCAG 4 cut(s) 30, 435, 594, 969
BseNI ACTGG 2 cut(s) 698, 955
BseRI GAGGAG 2 cut(s) 358, 1511
BseSI GKGCMC 2 cut(s) 83, 1246
BseXI GCAGC 5 cut(s) 16, 139, 574, 1146, 1168
Bsh1236I CGCG 2 cut(s) 451, 497
BshFI GGCC 4 cut(s) 72, 179, 1181, 1244
BsiHKAI GWGCWC 2 cut(s) 475, 1154
BsiSI CCGG 3 cut(s) 176, 635, 739
BslI CCNNNNNNNGG 7 cut(s) 62, 68, 529, 563, 650, 738, 1252
BsmAI GTCTC 1 cut(s) 911
BsnI GGCC 4 cut(s) 72, 179, 1181, 1244
Bsp120I GGGCCC 1 cut(s) 1242
Bsp1286I GDGCHC 4 cut(s) 83, 475, 1154, 1246
Bsp1407I TGTACA 1 cut(s) 759
Bsp143I GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
BspACI CCGC 2 cut(s) 1206, 1262
BspANI GGCC 4 cut(s) 72, 179, 1181, 1244
BspCNI CTCAG 4 cut(s) 31, 434, 593, 968
BspFNI CGCG 2 cut(s) 451, 497
BspLI GGNNCC 5 cut(s) 220, 384, 1243, 1244, 1245
BspPI GGATC 1 cut(s) 37
BsrDI GCAATG 3 cut(s) 358, 1263, 1271
BsrFI RCCGGY 1 cut(s) 634
BsrGI TGTACA 1 cut(s) 759
BsrI ACTGG 2 cut(s) 698, 955
BssAI RCCGGY 1 cut(s) 634
BssECI CCNNGG 4 cut(s) 369, 431, 942, 1468
BssMI GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
BssT1I CCWWGG 2 cut(s) 942, 1468
Bst2UI CCWGG 1 cut(s) 63
Bst4CI ACNGT 8 cut(s) 133, 218, 489, 612, 832, 893, 986, 1379
Bst6I CTCTTC 3 cut(s) 908, 1359, 1392
BstAUI TGTACA 1 cut(s) 759
BstC8I GCNNGC 2 cut(s) 636, 1154
BstDEI CTNAG 7 cut(s) 39, 122, 421, 580, 955, 1183, 1237
BstDSI CCRYGG 1 cut(s) 431
BstF5I GGATG 8 cut(s) 312, 432, 503, 807, 1193, 1214, 1309, 1342
BstFNI CGCG 2 cut(s) 451, 497
BstHHI GCGC 2 cut(s) 451, 497
BstKTI GATC 7 cut(s) 45, 361, 605, 1126, 1276, 1419, 1486
BstMAI GTCTC 1 cut(s) 911
BstMBI GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
BstMWI GCNNNNNNNGC 5 cut(s) 78, 640, 987, 1178, 1457
BstNI CCWGG 1 cut(s) 63
BstNSI RCATGY 1 cut(s) 537
BstSCI CCNGG 2 cut(s) 61, 738
BstSFI CTRYAG 1 cut(s) 889
BstSLI GKGCMC 2 cut(s) 83, 1246
BstUI CGCG 2 cut(s) 451, 497
BstV1I GCAGC 5 cut(s) 16, 139, 574, 1146, 1168
BstV2I GAAGAC 1 cut(s) 833
BstX2I RGATCY 1 cut(s) 42
BstYI RGATCY 1 cut(s) 42
Bsu36I CCTNAGG 1 cut(s) 1183
BsuRI GGCC 4 cut(s) 72, 179, 1181, 1244
BtgI CCRYGG 1 cut(s) 431
BtsCI GGATG 8 cut(s) 312, 432, 503, 807, 1193, 1214, 1309, 1342
BtsI GCAGTG 2 cut(s) 828, 1201
BtsIMutI CAGTG 3 cut(s) 828, 963, 1201
Cac8I GCNNGC 2 cut(s) 636, 1154
CaiI CAGNNNCTG 1 cut(s) 587
CfoI GCGC 2 cut(s) 451, 497
Cfr10I RCCGGY 1 cut(s) 634
Cfr13I GGNCC 5 cut(s) 70, 178, 836, 1242, 1243
Csp6I GTAC 2 cut(s) 345, 760
CviAII CATG 7 cut(s) 182, 362, 492, 534, 596, 785, 1393
CviQI GTAC 2 cut(s) 345, 760
DdeI CTNAG 7 cut(s) 39, 122, 421, 580, 955, 1183, 1237
DpnI GATC 7 cut(s) 44, 360, 604, 1125, 1275, 1418, 1485
DpnII GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
DrdI GACNNNNNNGTC 1 cut(s) 811
DseDI GACNNNNNNGTC 1 cut(s) 811
Eam1104I CTCTTC 3 cut(s) 908, 1359, 1392
EarI CTCTTC 3 cut(s) 908, 1359, 1392
Ecl136II GAGCTC 1 cut(s) 473
Eco130I CCWWGG 2 cut(s) 942, 1468
Eco147I AGGCCT 1 cut(s) 1181
Eco24I GRGCYC 2 cut(s) 475, 1246
Eco47I GGWCC 1 cut(s) 836
Eco53kI GAGCTC 1 cut(s) 473
Eco57I CTGAAG 1 cut(s) 1049
Eco81I CCTNAGG 1 cut(s) 1183
EcoICRI GAGCTC 1 cut(s) 473
EcoO109I RGGNCCY 2 cut(s) 1242, 1243
EcoRI GAATTC 2 cut(s) 203, 1213
EcoRII CCWGG 1 cut(s) 61
EcoT14I CCWWGG 2 cut(s) 942, 1468
EcoT22I ATGCAT 1 cut(s) 970
EcoT38I GRGCYC 2 cut(s) 475, 1246
ErhI CCWWGG 2 cut(s) 942, 1468
FaeI CATG 7 cut(s) 185, 365, 495, 537, 599, 788, 1396
FalI AAGNNNNNCTT 2 cut(s) 799, 831
FatI CATG 7 cut(s) 181, 361, 491, 533, 595, 784, 1392
FauNDI CATATG 1 cut(s) 75
FbaI TGATCA 3 cut(s) 358, 1123, 1273
FblI GTMKAC 2 cut(s) 510, 614
Fnu4HI GCNGC 6 cut(s) 30, 153, 588, 1157, 1160, 1262
FokI GGATG 8 cut(s) 299, 439, 490, 814, 1200, 1221, 1316, 1349
FriOI GRGCYC 2 cut(s) 475, 1246
Fsp4HI GCNGC 6 cut(s) 30, 153, 588, 1157, 1160, 1262
FspBI CTAG 3 cut(s) 47, 348, 992
GlaI GCGC 2 cut(s) 450, 496
GluI GCNGC 6 cut(s) 30, 153, 588, 1157, 1160, 1262
HaeIII GGCC 4 cut(s) 72, 179, 1181, 1244
HapII CCGG 3 cut(s) 176, 635, 739
HhaI GCGC 2 cut(s) 451, 497
Hin1II CATG 7 cut(s) 185, 365, 495, 537, 599, 788, 1396
Hin6I GCGC 2 cut(s) 449, 495
HinP1I GCGC 2 cut(s) 449, 495
HincII GTYRAC 1 cut(s) 1465
HindII GTYRAC 1 cut(s) 1465
HindIII AAGCTT 3 cut(s) 189, 1082, 1227
HinfI GANTC 8 cut(s) 126, 419, 578, 654, 721, 938, 1115, 1164
HpaII CCGG 3 cut(s) 176, 635, 739
HphI GGTGA 2 cut(s) 368, 600
Hpy166II GTNNAC 4 cut(s) 511, 615, 710, 1465
Hpy188I TCNGA 9 cut(s) 214, 241, 583, 1029, 1064, 1089, 1128, 1421, 1483
Hpy188III TCNNGA 5 cut(s) 316, 409, 860, 1141, 1301
Hpy8I GTNNAC 4 cut(s) 511, 615, 710, 1465
HpyAV CCTTC 3 cut(s) 461, 521, 1069
HpyCH4III ACNGT 8 cut(s) 133, 218, 489, 612, 832, 893, 986, 1379
HpyCH4IV ACGT 1 cut(s) 776
HpyCH4V TGCA 2 cut(s) 503, 968
HpyF10VI GCNNNNNNNGC 5 cut(s) 78, 640, 987, 1178, 1457
HpyF3I CTNAG 7 cut(s) 39, 122, 421, 580, 955, 1183, 1237
HpySE526I ACGT 1 cut(s) 776
Hsp92II CATG 7 cut(s) 185, 365, 495, 537, 599, 788, 1396
HspAI GCGC 2 cut(s) 449, 495
KroI GCCGGC 1 cut(s) 634
KroNI GCCGGC 1 cut(s) 636
Ksp22I TGATCA 3 cut(s) 358, 1123, 1273
Kzo9I GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
LmnI GCTCC 6 cut(s) 37, 411, 470, 478, 559, 1484
Lsp1109I GCAGC 5 cut(s) 16, 139, 574, 1146, 1168
LweI GCATC 4 cut(s) 417, 512, 977, 1178
MaeI CTAG 3 cut(s) 47, 348, 992
MaeII ACGT 1 cut(s) 776
MaeIII GTNAC 3 cut(s) 127, 1195, 1351
MalI GATC 7 cut(s) 44, 360, 604, 1125, 1275, 1418, 1485
MboI GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
MboII GAAGA 9 cut(s) 239, 612, 838, 887, 895, 1042, 1102, 1376, 1409
MfeI CAATTG 2 cut(s) 755, 1445
MflI RGATCY 1 cut(s) 42
MhlI GDGCHC 4 cut(s) 83, 475, 1154, 1246
MlyI GAGTC 6 cut(s) 135, 413, 572, 663, 932, 1173
Mph1103I ATGCAT 1 cut(s) 970
MroNI GCCGGC 1 cut(s) 634
MroXI GAANNNNTTC 3 cut(s) 381, 725, 1094
MseI TTAA 1 cut(s) 1520
MslI CAYNNNNRTG 2 cut(s) 490, 522
MspA1I CMGCKG 2 cut(s) 1121, 1159
MspI CCGG 3 cut(s) 176, 635, 739
MspR9I CCNGG 2 cut(s) 63, 740
MunI CAATTG 2 cut(s) 755, 1445
MvaI CCWGG 1 cut(s) 63
MvnI CGCG 2 cut(s) 451, 497
MwoI GCNNNNNNNGC 5 cut(s) 78, 640, 987, 1178, 1457
NaeI GCCGGC 1 cut(s) 636
NciI CCSGG 1 cut(s) 740
NdeI CATATG 1 cut(s) 75
NdeII GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
NgoMIV GCCGGC 1 cut(s) 634
NlaIII CATG 7 cut(s) 185, 365, 495, 537, 599, 788, 1396
NlaIV GGNNCC 5 cut(s) 220, 384, 1243, 1244, 1245
NmuCI GTSAC 1 cut(s) 127
NsiI ATGCAT 1 cut(s) 970
NspI RCATGY 1 cut(s) 537
OliI CACNNNNGTG 1 cut(s) 522
PceI AGGCCT 1 cut(s) 1181
PdiI GCCGGC 1 cut(s) 636
PdmI GAANNNNTTC 3 cut(s) 381, 725, 1094
PfeI GAWTC 2 cut(s) 721, 1115
PflMI CCANNNNNTGG 2 cut(s) 62, 650
PfoI TCCNGGA 1 cut(s) 738
PkrI GCNGC 6 cut(s) 31, 154, 589, 1158, 1161, 1263
PleI GAGTC 6 cut(s) 134, 413, 572, 662, 932, 1172
PpsI GAGTC 6 cut(s) 134, 413, 572, 662, 932, 1172
Psp124BI GAGCTC 1 cut(s) 475
Psp6I CCWGG 1 cut(s) 61
PspGI CCWGG 1 cut(s) 61
PspN4I GGNNCC 5 cut(s) 220, 384, 1243, 1244, 1245
PspOMI GGGCCC 1 cut(s) 1242
PspPI GGNCC 5 cut(s) 70, 178, 836, 1242, 1243
PsrI GAACNNNNNNTAC 2 cut(s) 1025, 1057
PstNI CAGNNNCTG 1 cut(s) 587
PsuI RGATCY 1 cut(s) 42
PvuII CAGCTG 2 cut(s) 1121, 1159
RsaI GTAC 2 cut(s) 346, 761
RsaNI GTAC 2 cut(s) 345, 760
RseI CAYNNNNRTG 2 cut(s) 490, 522
SacI GAGCTC 1 cut(s) 475
SaqAI TTAA 1 cut(s) 1520
SatI GCNGC 6 cut(s) 30, 153, 588, 1157, 1160, 1262
Sau3AI GATC 7 cut(s) 42, 358, 602, 1123, 1273, 1416, 1483
Sau96I GGNCC 5 cut(s) 70, 178, 836, 1242, 1243
SchI GAGTC 6 cut(s) 135, 413, 572, 663, 932, 1173
ScrFI CCNGG 2 cut(s) 63, 740
SduI GDGCHC 4 cut(s) 83, 475, 1154, 1246
SfaNI GCATC 4 cut(s) 417, 512, 977, 1178
SfcI CTRYAG 1 cut(s) 889
SinI GGWCC 1 cut(s) 836
SmiMI CAYNNNNRTG 2 cut(s) 490, 522
SmlI CTYRAG 2 cut(s) 395, 401
SmoI CTYRAG 2 cut(s) 395, 401
SseBI AGGCCT 1 cut(s) 1181
SsiI CCGC 2 cut(s) 1206, 1262
SspI AATATT 2 cut(s) 627, 1492
SspMI CTAG 3 cut(s) 47, 348, 992
SstI GAGCTC 1 cut(s) 475
StuI AGGCCT 1 cut(s) 1181
StyD4I CCNGG 2 cut(s) 61, 738
StyI CCWWGG 2 cut(s) 942, 1468
TaaI ACNGT 8 cut(s) 133, 218, 489, 612, 832, 893, 986, 1379
TaiI ACGT 1 cut(s) 779
TaqI TCGA 2 cut(s) 906, 1217
TatI WGTACW 2 cut(s) 344, 759
TauI GCSGC 1 cut(s) 1264
TfiI GAWTC 2 cut(s) 721, 1115
Tru1I TTAA 1 cut(s) 1520
Tru9I TTAA 1 cut(s) 1520
TscAI CASTG 3 cut(s) 828, 963, 1208
TseFI GTSAC 1 cut(s) 127
TseI GCWGC 5 cut(s) 29, 152, 587, 1156, 1159
Tsp45I GTSAC 1 cut(s) 127
TspDTI ATGAA 2 cut(s) 196, 1087
TspGWI ACGGA 3 cut(s) 496, 512, 837
TspRI CASTG 3 cut(s) 828, 963, 1208
Van91I CCANNNNNTGG 2 cut(s) 62, 650
VpaK11BI GGWCC 1 cut(s) 836
XapI RAATTY 3 cut(s) 203, 1093, 1213
XceI RCATGY 1 cut(s) 537
XmiI GTMKAC 2 cut(s) 510, 614
XmnI GAANNNNTTC 3 cut(s) 381, 725, 1094
XspI CTAG 3 cut(s) 47, 348, 992
Zsp2I ATGCAT 1 cut(s) 970
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.