Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccB1I | GGYRCC | 1 cut(s) | 561 |
| AccB7I | CCANNNNNTGG | 1 cut(s) | 571 |
| AccII | CGCG | 3 cut(s) | 150, 1103, 1618 |
| AciI | CCGC | 2 cut(s) | 462, 1575 |
| AclWI | GGATC | 1 cut(s) | 1561 |
| AcoI | YGGCCR | 2 cut(s) | 162, 172 |
| AcsI | RAATTY | 3 cut(s) | 1007, 1052, 1238 |
| AcuI | CTGAAG | 2 cut(s) | 718, 803 |
| AcyI | GRCGYC | 1 cut(s) | 1119 |
| AdeI | CACNNNGTG | 1 cut(s) | 536 |
| AfaI | GTAC | 1 cut(s) | 1061 |
| AfiI | CCNNNNNNNGG | 4 cut(s) | 232, 415, 468, 571 |
| AflIII | ACRYGT | 1 cut(s) | 944 |
| AgsI | TTSAA | 3 cut(s) | 239, 406, 1415 |
| AjiI | CACGTC | 1 cut(s) | 1622 |
| AjnI | CCWGG | 1 cut(s) | 1383 |
| AleI | CACNNNNGTG | 1 cut(s) | 228 |
| AloI | GAACNNNNNNTCC | 2 cut(s) | 373, 405 |
| AluBI | AGCT | 6 cut(s) | 738, 781, 1156, 1210, 1272, 1436 |
| AluI | AGCT | 6 cut(s) | 738, 781, 1156, 1210, 1272, 1436 |
| Alw21I | GWGCWC | 1 cut(s) | 1158 |
| Alw26I | GTCTC | 2 cut(s) | 296, 521 |
| AlwI | GGATC | 1 cut(s) | 1561 |
| AoxI | GGCC | 5 cut(s) | 162, 172, 552, 997, 1647 |
| ApeKI | GCWGC | 3 cut(s) | 884, 1232, 1244 |
| ApoI | RAATTY | 3 cut(s) | 1007, 1052, 1238 |
| AseI | ATTAAT | 1 cut(s) | 351 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 27 |
| AspLEI | GCGC | 2 cut(s) | 150, 521 |
| AspS9I | GGNCC | 2 cut(s) | 158, 552 |
| AsuC2I | CCSGG | 1 cut(s) | 410 |
| AsuHPI | GGTGA | 2 cut(s) | 29, 338 |
| AvaII | GGWCC | 1 cut(s) | 158 |
| BanI | GGYRCC | 1 cut(s) | 561 |
| BanII | GRGCYC | 2 cut(s) | 1158, 1503 |
| Bbv12I | GWGCWC | 1 cut(s) | 1158 |
| BbvI | GCAGC | 3 cut(s) | 871, 1244, 1256 |
| BccI | CCATC | 4 cut(s) | 173, 476, 1443, 1518 |
| BceAI | ACGGC | 1 cut(s) | 159 |
| BcgI | CGANNNNNNTGC | 6 cut(s) | 353, 387, 668, 678, 702, 712 |
| BciT130I | CCWGG | 1 cut(s) | 1385 |
| BciVI | GTATCC | 1 cut(s) | 1319 |
| BclI | TGATCA | 2 cut(s) | 91, 1690 |
| BcnI | CCSGG | 1 cut(s) | 410 |
| BcoDI | GTCTC | 2 cut(s) | 296, 521 |
| BfaI | CTAG | 2 cut(s) | 524, 1508 |
| BfmI | CTRYAG | 2 cut(s) | 1063, 1437 |
| BfuI | GTATCC | 1 cut(s) | 1319 |
| BglII | AGATCT | 1 cut(s) | 399 |
| BisI | GCNGC | 3 cut(s) | 885, 1233, 1245 |
| BlsI | GCNGC | 3 cut(s) | 886, 1234, 1246 |
| Bme1390I | CCNGG | 2 cut(s) | 410, 1385 |
| Bme18I | GGWCC | 1 cut(s) | 158 |
| BmgBI | CACGTC | 1 cut(s) | 1622 |
| BmgT120I | GGNCC | 2 cut(s) | 158, 552 |
| BmiI | GGNNCC | 3 cut(s) | 553, 563, 1502 |
| BmrFI | CCNGG | 2 cut(s) | 410, 1385 |
| BmsI | GCATC | 1 cut(s) | 1614 |
| BpmI | CTGGAG | 1 cut(s) | 1209 |
| Bpu10I | CCTNAGC | 1 cut(s) | 1444 |
| BpuMI | CCSGG | 1 cut(s) | 410 |
| BsaBI | GATNNNNATC | 2 cut(s) | 8, 90 |
| BsaHI | GRCGYC | 1 cut(s) | 1119 |
| BsaI | GGTCTC | 1 cut(s) | 296 |
| BsaJI | CCNNGG | 5 cut(s) | 226, 409, 810, 1384, 1570 |
| BsaXI | ACNNNNNCTCC | 4 cut(s) | 1182, 1212, 1422, 1452 |
| Bsc4I | CCNNNNNNNGG | 4 cut(s) | 232, 415, 468, 571 |
| Bse1I | ACTGG | 3 cut(s) | 976, 1090, 1192 |
| Bse3DI | GCAATG | 2 cut(s) | 255, 755 |
| Bse8I | GATNNNNATC | 2 cut(s) | 8, 90 |
| BseBI | CCWGG | 1 cut(s) | 1385 |
| BseDI | CCNNGG | 5 cut(s) | 226, 409, 810, 1384, 1570 |
| BseGI | GGATG | 6 cut(s) | 487, 1353, 1380, 1454, 1529, 1569 |
| BseJI | GATNNNNATC | 2 cut(s) | 8, 90 |
| BseLI | CCNNNNNNNGG | 4 cut(s) | 232, 415, 468, 571 |
| BseMI | GCAATG | 2 cut(s) | 255, 755 |
| BseMII | CTCAG | 4 cut(s) | 287, 976, 1458, 1655 |
| BseNI | ACTGG | 3 cut(s) | 976, 1090, 1192 |
| BseRI | GAGGAG | 1 cut(s) | 1715 |
| BseX3I | CGGCCG | 1 cut(s) | 172 |
| BseXI | GCAGC | 3 cut(s) | 871, 1244, 1256 |
| BseYI | CCCAGC | 1 cut(s) | 1210 |
| Bsh1236I | CGCG | 3 cut(s) | 150, 1103, 1618 |
| Bsh1285I | CGRYCG | 1 cut(s) | 175 |
| BshFI | GGCC | 5 cut(s) | 164, 174, 554, 999, 1649 |
| BshNI | GGYRCC | 1 cut(s) | 561 |
| BsiEI | CGRYCG | 1 cut(s) | 175 |
| BsiHKAI | GWGCWC | 1 cut(s) | 1158 |
| BsiSI | CCGG | 3 cut(s) | 161, 219, 409 |
| BslFI | GGGAC | 1 cut(s) | 501 |
| BslI | CCNNNNNNNGG | 4 cut(s) | 232, 415, 468, 571 |
| BsmAI | GTCTC | 2 cut(s) | 296, 521 |
| BsmFI | GGGAC | 1 cut(s) | 501 |
| BsmI | GAATGC | 3 cut(s) | 618, 1150, 1307 |
| BsnI | GGCC | 5 cut(s) | 164, 174, 554, 999, 1649 |
| Bso31I | GGTCTC | 1 cut(s) | 296 |
| Bsp1286I | GDGCHC | 2 cut(s) | 1158, 1503 |
| Bsp143I | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| Bsp68I | TCGCGA | 1 cut(s) | 1618 |
| BspACI | CCGC | 2 cut(s) | 462, 1575 |
| BspANI | GGCC | 5 cut(s) | 164, 174, 554, 999, 1649 |
| BspCNI | CTCAG | 4 cut(s) | 288, 975, 1457, 1654 |
| BspFNI | CGCG | 3 cut(s) | 150, 1103, 1618 |
| BspHI | TCATGA | 1 cut(s) | 1158 |
| BspLI | GGNNCC | 3 cut(s) | 553, 563, 1502 |
| BspPI | GGATC | 1 cut(s) | 1561 |
| BspT107I | GGYRCC | 1 cut(s) | 561 |
| BspTNI | GGTCTC | 1 cut(s) | 296 |
| BsrDI | GCAATG | 2 cut(s) | 255, 755 |
| BsrI | ACTGG | 3 cut(s) | 976, 1090, 1192 |
| BssECI | CCNNGG | 5 cut(s) | 226, 409, 810, 1384, 1570 |
| BssMI | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| BssNI | GRCGYC | 1 cut(s) | 1119 |
| BssT1I | CCWWGG | 3 cut(s) | 226, 810, 1570 |
| Bst2UI | CCWGG | 1 cut(s) | 1385 |
| Bst4CI | ACNGT | 4 cut(s) | 503, 675, 1409, 1594 |
| BstACI | GRCGYC | 1 cut(s) | 1119 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 1241 |
| BstC8I | GCNNGC | 7 cut(s) | 440, 517, 543, 779, 1455, 1651, 1655 |
| BstDEI | CTNAG | 4 cut(s) | 296, 962, 1444, 1641 |
| BstF5I | GGATG | 6 cut(s) | 487, 1353, 1380, 1454, 1529, 1569 |
| BstFNI | CGCG | 3 cut(s) | 150, 1103, 1618 |
| BstHHI | GCGC | 2 cut(s) | 150, 521 |
| BstKTI | GATC | 5 cut(s) | 94, 198, 402, 1569, 1693 |
| BstMAI | GTCTC | 2 cut(s) | 296, 521 |
| BstMBI | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| BstMCI | CGRYCG | 1 cut(s) | 175 |
| BstMWI | GCNNNNNNNGC | 8 cut(s) | 516, 551, 778, 890, 1178, 1241, 1463, 1646 |
| BstNI | CCWGG | 1 cut(s) | 1385 |
| BstNSI | RCATGY | 1 cut(s) | 948 |
| BstSCI | CCNGG | 2 cut(s) | 408, 1383 |
| BstSFI | CTRYAG | 2 cut(s) | 1063, 1437 |
| BstUI | CGCG | 3 cut(s) | 150, 1103, 1618 |
| BstV1I | GCAGC | 3 cut(s) | 871, 1244, 1256 |
| BstX2I | RGATCY | 1 cut(s) | 399 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 966 |
| BstYI | RGATCY | 1 cut(s) | 399 |
| BstZI | CGGCCG | 1 cut(s) | 172 |
| BsuI | GTATCC | 1 cut(s) | 1319 |
| BsuRI | GGCC | 5 cut(s) | 164, 174, 554, 999, 1649 |
| BtgZI | GCGATG | 1 cut(s) | 1599 |
| BtrI | CACGTC | 1 cut(s) | 1622 |
| BtsCI | GGATG | 6 cut(s) | 487, 1353, 1380, 1454, 1529, 1569 |
| BtsI | GCAGTG | 1 cut(s) | 1351 |
| BtsIMutI | CAGTG | 3 cut(s) | 81, 1351, 1599 |
| BtuMI | TCGCGA | 1 cut(s) | 1618 |
| Cac8I | GCNNGC | 7 cut(s) | 440, 517, 543, 779, 1455, 1651, 1655 |
| CciI | TCATGA | 1 cut(s) | 1158 |
| CfoI | GCGC | 2 cut(s) | 150, 521 |
| Cfr13I | GGNCC | 2 cut(s) | 158, 552 |
| CpoI | CGGWCCG | 1 cut(s) | 158 |
| CseI | GACGC | 1 cut(s) | 1127 |
| Csp6I | GTAC | 1 cut(s) | 1060 |
| CspI | CGGWCCG | 1 cut(s) | 158 |
| CviQI | GTAC | 1 cut(s) | 1060 |
| DdeI | CTNAG | 4 cut(s) | 296, 962, 1444, 1641 |
| DpnI | GATC | 5 cut(s) | 93, 197, 401, 1568, 1692 |
| DpnII | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| DraI | TTTAAA | 1 cut(s) | 312 |
| DraIII | CACNNNGTG | 1 cut(s) | 536 |
| EaeI | YGGCCR | 2 cut(s) | 162, 172 |
| EagI | CGGCCG | 1 cut(s) | 172 |
| EciI | GGCGGA | 1 cut(s) | 1590 |
| Ecl136II | GAGCTC | 1 cut(s) | 1156 |
| EclXI | CGGCCG | 1 cut(s) | 172 |
| Eco130I | CCWWGG | 3 cut(s) | 226, 810, 1570 |
| Eco24I | GRGCYC | 2 cut(s) | 1158, 1503 |
| Eco31I | GGTCTC | 1 cut(s) | 296 |
| Eco32I | GATATC | 1 cut(s) | 901 |
| Eco47I | GGWCC | 1 cut(s) | 158 |
| Eco52I | CGGCCG | 1 cut(s) | 172 |
| Eco53kI | GAGCTC | 1 cut(s) | 1156 |
| Eco57I | CTGAAG | 2 cut(s) | 718, 803 |
| EcoICRI | GAGCTC | 1 cut(s) | 1156 |
| EcoRII | CCWGG | 1 cut(s) | 1383 |
| EcoRV | GATATC | 1 cut(s) | 901 |
| EcoT14I | CCWWGG | 3 cut(s) | 226, 810, 1570 |
| EcoT38I | GRGCYC | 2 cut(s) | 1158, 1503 |
| ErhI | CCWWGG | 3 cut(s) | 226, 810, 1570 |
| FalI | AAGNNNNNCTT | 2 cut(s) | 18, 50 |
| FaqI | GGGAC | 1 cut(s) | 501 |
| FauNDI | CATATG | 2 cut(s) | 567, 1553 |
| FbaI | TGATCA | 2 cut(s) | 91, 1690 |
| Fnu4HI | GCNGC | 3 cut(s) | 885, 1233, 1245 |
| FokI | GGATG | 6 cut(s) | 494, 1340, 1367, 1461, 1536, 1576 |
| FriOI | GRGCYC | 2 cut(s) | 1158, 1503 |
| Fsp4HI | GCNGC | 3 cut(s) | 885, 1233, 1245 |
| FspBI | CTAG | 2 cut(s) | 524, 1508 |
| GlaI | GCGC | 2 cut(s) | 149, 520 |
| GluI | GCNGC | 3 cut(s) | 885, 1233, 1245 |
| GsaI | CCCAGC | 1 cut(s) | 1214 |
| GsuI | CTGGAG | 1 cut(s) | 1209 |
| HaeIII | GGCC | 5 cut(s) | 164, 174, 554, 999, 1649 |
| HapII | CCGG | 3 cut(s) | 161, 219, 409 |
| HgaI | GACGC | 1 cut(s) | 1127 |
| HhaI | GCGC | 2 cut(s) | 150, 521 |
| Hin1I | GRCGYC | 1 cut(s) | 1119 |
| Hin6I | GCGC | 2 cut(s) | 148, 519 |
| HinP1I | GCGC | 2 cut(s) | 148, 519 |
| HincII | GTYRAC | 2 cut(s) | 16, 1674 |
| HindII | GTYRAC | 2 cut(s) | 16, 1674 |
| HinfI | GANTC | 9 cut(s) | 9, 56, 131, 451, 655, 1068, 1105, 1162, 1265 |
| HpaII | CCGG | 3 cut(s) | 161, 219, 409 |
| HphI | GGTGA | 2 cut(s) | 29, 338 |
| Hpy166II | GTNNAC | 5 cut(s) | 16, 358, 959, 1117, 1674 |
| Hpy188I | TCNGA | 5 cut(s) | 654, 660, 679, 1644, 1695 |
| Hpy8I | GTNNAC | 5 cut(s) | 16, 358, 959, 1117, 1674 |
| Hpy99I | CGWCG | 1 cut(s) | 1623 |
| HpyAV | CCTTC | 4 cut(s) | 196, 323, 1183, 1639 |
| HpyCH4III | ACNGT | 4 cut(s) | 503, 675, 1409, 1594 |
| HpyCH4IV | ACGT | 2 cut(s) | 684, 1621 |
| HpyF10VI | GCNNNNNNNGC | 8 cut(s) | 516, 551, 778, 890, 1178, 1241, 1463, 1646 |
| HpyF3I | CTNAG | 4 cut(s) | 296, 962, 1444, 1641 |
| HpySE526I | ACGT | 2 cut(s) | 684, 1621 |
| Hsp92I | GRCGYC | 1 cut(s) | 1119 |
| HspAI | GCGC | 2 cut(s) | 148, 519 |
| Ksp22I | TGATCA | 2 cut(s) | 91, 1690 |
| Kzo9I | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| LmnI | GCTCC | 3 cut(s) | 1153, 1506, 1702 |
| Lsp1109I | GCAGC | 3 cut(s) | 871, 1244, 1256 |
| LweI | GCATC | 1 cut(s) | 1614 |
| MaeI | CTAG | 2 cut(s) | 524, 1508 |
| MaeII | ACGT | 2 cut(s) | 684, 1621 |
| MaeIII | GTNAC | 4 cut(s) | 793, 940, 1543, 1609 |
| MalI | GATC | 5 cut(s) | 93, 197, 401, 1568, 1692 |
| MboI | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| MboII | GAAGA | 5 cut(s) | 26, 35, 796, 1168, 1279 |
| MflI | RGATCY | 1 cut(s) | 399 |
| MhlI | GDGCHC | 2 cut(s) | 1158, 1503 |
| MluCI | AATT | 5 cut(s) | 1007, 1052, 1238, 1318, 1395 |
| MlyI | GAGTC | 2 cut(s) | 445, 1099 |
| MmeI | TCCRAC | 2 cut(s) | 947, 1381 |
| MroXI | GAANNNNTTC | 1 cut(s) | 27 |
| MseI | TTAA | 6 cut(s) | 311, 344, 351, 387, 1365, 1404 |
| MslI | CAYNNNNRTG | 2 cut(s) | 228, 1139 |
| MspA1I | CMGCKG | 1 cut(s) | 781 |
| MspI | CCGG | 3 cut(s) | 161, 219, 409 |
| MspR9I | CCNGG | 2 cut(s) | 410, 1385 |
| Mva1269I | GAATGC | 3 cut(s) | 618, 1150, 1307 |
| MvaI | CCWGG | 1 cut(s) | 1385 |
| MvnI | CGCG | 3 cut(s) | 150, 1103, 1618 |
| MwoI | GCNNNNNNNGC | 8 cut(s) | 516, 551, 778, 890, 1178, 1241, 1463, 1646 |
| NciI | CCSGG | 1 cut(s) | 410 |
| NdeI | CATATG | 2 cut(s) | 567, 1553 |
| NdeII | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| NlaIV | GGNNCC | 3 cut(s) | 553, 563, 1502 |
| NmuCI | GTSAC | 2 cut(s) | 793, 1609 |
| NruI | TCGCGA | 1 cut(s) | 1618 |
| NspI | RCATGY | 1 cut(s) | 948 |
| OliI | CACNNNNGTG | 1 cut(s) | 228 |
| PagI | TCATGA | 1 cut(s) | 1158 |
| PciI | ACATGT | 1 cut(s) | 944 |
| PctI | GAATGC | 3 cut(s) | 618, 1150, 1307 |
| PdmI | GAANNNNTTC | 1 cut(s) | 27 |
| PfeI | GAWTC | 7 cut(s) | 9, 56, 131, 655, 1068, 1162, 1265 |
| PflMI | CCANNNNNTGG | 1 cut(s) | 571 |
| PkrI | GCNGC | 3 cut(s) | 886, 1234, 1246 |
| PleI | GAGTC | 2 cut(s) | 445, 1099 |
| PpsI | GAGTC | 2 cut(s) | 445, 1099 |
| PscI | ACATGT | 1 cut(s) | 944 |
| PshBI | ATTAAT | 1 cut(s) | 351 |
| Psp124BI | GAGCTC | 1 cut(s) | 1158 |
| Psp6I | CCWGG | 1 cut(s) | 1383 |
| PspFI | CCCAGC | 1 cut(s) | 1210 |
| PspGI | CCWGG | 1 cut(s) | 1383 |
| PspN4I | GGNNCC | 3 cut(s) | 553, 563, 1502 |
| PspPI | GGNCC | 2 cut(s) | 158, 552 |
| PsuI | RGATCY | 1 cut(s) | 399 |
| PvuII | CAGCTG | 1 cut(s) | 781 |
| RruI | TCGCGA | 1 cut(s) | 1618 |
| RsaI | GTAC | 1 cut(s) | 1061 |
| RsaNI | GTAC | 1 cut(s) | 1060 |
| RseI | CAYNNNNRTG | 2 cut(s) | 228, 1139 |
| Rsr2I | CGGWCCG | 1 cut(s) | 158 |
| RsrII | CGGWCCG | 1 cut(s) | 158 |
| SacI | GAGCTC | 1 cut(s) | 1158 |
| SaqAI | TTAA | 6 cut(s) | 311, 344, 351, 387, 1365, 1404 |
| SatI | GCNGC | 3 cut(s) | 885, 1233, 1245 |
| Sau3AI | GATC | 5 cut(s) | 91, 195, 399, 1566, 1690 |
| Sau96I | GGNCC | 2 cut(s) | 158, 552 |
| SchI | GAGTC | 2 cut(s) | 445, 1099 |
| ScrFI | CCNGG | 2 cut(s) | 410, 1385 |
| SduI | GDGCHC | 2 cut(s) | 1158, 1503 |
| SfaNI | GCATC | 1 cut(s) | 1614 |
| SfcI | CTRYAG | 2 cut(s) | 1063, 1437 |
| SinI | GGWCC | 1 cut(s) | 158 |
| SmiMI | CAYNNNNRTG | 2 cut(s) | 228, 1139 |
| Sse9I | AATT | 5 cut(s) | 1007, 1052, 1238, 1318, 1395 |
| SsiI | CCGC | 2 cut(s) | 462, 1575 |
| SspMI | CTAG | 2 cut(s) | 524, 1508 |
| SstI | GAGCTC | 1 cut(s) | 1158 |
| StyD4I | CCNGG | 2 cut(s) | 408, 1383 |
| StyI | CCWWGG | 3 cut(s) | 226, 810, 1570 |
| TaaI | ACNGT | 4 cut(s) | 503, 675, 1409, 1594 |
| TaiI | ACGT | 2 cut(s) | 687, 1624 |
| TaqI | TCGA | 1 cut(s) | 1202 |
| TaqII | GACCGA | 1 cut(s) | 146 |
| TasI | AATT | 5 cut(s) | 1007, 1052, 1238, 1318, 1395 |
| TfiI | GAWTC | 7 cut(s) | 9, 56, 131, 655, 1068, 1162, 1265 |
| Tru1I | TTAA | 6 cut(s) | 311, 344, 351, 387, 1365, 1404 |
| Tru9I | TTAA | 6 cut(s) | 311, 344, 351, 387, 1365, 1404 |
| TscAI | CASTG | 3 cut(s) | 88, 1351, 1599 |
| TseFI | GTSAC | 2 cut(s) | 793, 1609 |
| TseI | GCWGC | 3 cut(s) | 884, 1232, 1244 |
| Tsp45I | GTSAC | 2 cut(s) | 793, 1609 |
| TspDTI | ATGAA | 4 cut(s) | 20, 818, 1154, 1157 |
| TspGWI | ACGGA | 1 cut(s) | 1301 |
| TspRI | CASTG | 3 cut(s) | 88, 1351, 1599 |
| Van91I | CCANNNNNTGG | 1 cut(s) | 571 |
| VpaK11BI | GGWCC | 1 cut(s) | 158 |
| VspI | ATTAAT | 1 cut(s) | 351 |
| XapI | RAATTY | 3 cut(s) | 1007, 1052, 1238 |
| XceI | RCATGY | 1 cut(s) | 948 |
| XmnI | GAANNNNTTC | 1 cut(s) | 27 |
| XspI | CTAG | 2 cut(s) | 524, 1508 |