Basic Information

Type: gene

Biological Identity

Species

rosa_chinensis

Chromosome

Orthogroup ID

OG0000815

Physical Location & Seq

Genomic Coordinates Forward (+)

21402000 .. 21405189

Gene Structure 3190 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

PRQ56058

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1146 bp

ATGTCCAACAGTACTGCTGGCAAGGTGATCAAGTGCAAAGCTGCGGTAGCCTGGGAAGCTGGGAAGCCGCTGGTTATTGAGGAAGTGGAGGTGGCACCACCCCAGAAACATGAAGTACGCTTGAAGATCCTCTTTACGGCTCTATGCCACACTGATGTATACTTCTGGGAAGCAAAGGGACAAAATCCACTGTTCCCTCGGATTTTTGGTCATGAAGCTGGAGGAATCGTGGAAAGCGTAGGTGAGGGTGTAACTGAACTCCAACCGGGAGACCATGTCCTCCCGGTGTTCACCGGAGAATGCAAGGAGTGCGCACATTGTAAGTCAGAGGAAAGCAACATGTGTGATCTCCTAAGGATTAATACCGACAGGGGTACTATGCTCAATGATGGCCAGACCCGGTTTTCCAAGGATGGAAAGCCAATTTATCACTTTGTTGGTACCTCTACATTCAGTGAATACACTGTTTCACATGTTGGTTCCGTTGCGAAGATCAACCCTGCAGCGCCTCTTGACAAAGTTTGTGTTCTTAGTTGCGGAATTTGTACAGGTTTTGGTGCTACTGTAAATGTTGCAAAGCCGAAAAAGGGTTCATCTGTTGCAATTTTCGGATTGGGTGCTGTTGGTCTTGCTGCTGCGGAAGGTGCAAGGGTTTCTGGGGCTTCAAGGATCATTGGGGTTGATCTGAACTCCAACCGATTTGAGGAAGCCAAGAAGTTTGGGGTGAATGAATTTGTGAATCCAAAAGATCATAACAAACCTGTTCAGGAGGTGATAGCTGAGATGACCAATGGTGGAGTTGATAGGAGTGTTGAGTGCACTGGAAGCATCCAGGCTATGATCTCTGCCTTTGAATGTGTTCATGATGGTTGGGGAGTTGCTGTACTTGTTGGAGTGCCAAACAAAGACGATGCGTTCAAAACCCATCCGATGAACTTCTTGAATGAGAGGACTCTAAAGGGTACTTTCTATGGTAACTACAAGCCCCGCACCGATCTGCCTTGTGTTGTGGAGAAGTACATGAACAAGGAGATGGAATTGGACAAATTTATCACTCACTCTGTTCCTTTCTCTGAGATCAACAAGGCATTTGAGTACATGCTGGCAGGACAGGGAATCCGGTGCATCATCCGCATGGAGCATTAG

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0000302 GO:0001101 GO:0001666 GO:0003674 GO:0003824 GO:0004022 GO:0005488 GO:0005515 GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0005829 GO:0005886 GO:0006950 GO:0006970 GO:0006979 GO:0008150 GO:0008152 GO:0009266 GO:0009409 GO:0009410 GO:0009413 GO:0009414 GO:0009415 GO:0009628 GO:0009636 GO:0009651 GO:0009719 GO:0009725 GO:0009737 GO:0009743 GO:0009744 GO:0010033 GO:0010035 GO:0010038 GO:0010243 GO:0014070 GO:0014074 GO:0016020 GO:0016491 GO:0016614 GO:0016616 GO:0031000 GO:0032355 GO:0033993 GO:0034285 GO:0036270 GO:0036293 GO:0042221 GO:0042493 GO:0042542 GO:0042802 GO:0042803 GO:0043279 GO:0044424 GO:0044444 GO:0044464 GO:0046677 GO:0046686 GO:0046983 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0050896 GO:0055114 GO:0065007 GO:0070482 GO:0071944 GO:0080134 GO:0080135 GO:0097305 GO:1900037 GO:1900039 GO:1901698 GO:1901700

KEGG Pathways

Metabolic & Signaling

ko00010 ko00071 ko00350 ko00592 ko01100 ko01110 ko01120 map00010 map00071 map00350 map00592 map01100 map01110 map01120

Pfam Domains

Protein Families

ADH_N ADH_zinc_N

Protein Analysis

381

Amino Acids

41.44

Weight (kDa)

6.33

Isoelectric Point (pI)

30.57

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
ADH_N	PF08240	36 - 165	2.5e-19	Alcohol dehydrogenase GroES-like domain
Glu_dehyd_C	PF16912	198 - 366	8.8e-06	Glucose dehydrogenase C-terminus
ADH_zinc_N	PF00107	207 - 338	8.6e-27	Zinc-binding dehydrogenase

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0000815)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT1G77120
fragaria_vesca	FvH4_2g14750 FvH4_2g14750 FvH4_2g14760 FvH4_2g14760
malus_domestica	MD05G1013200.v1.1 MD05G1013400.v1.1 MD05G1179800.v1.1 MD05G1180800.v1.1 MD08G1068100.v1.1 MD09G1211500.v1.1 MD10G1013800.v1.1 MD10G1013900.v1.1 MD10G1014200.v1.1 MD10G1014500.v1.1 MD11G1004800.v1.1
prunus_persica	Prupe.8G018100_v2.0.a1 Prupe.8G018300_v2.0.a1 Prupe.8G018300_v2.0.a1 Prupe.8G018400_v2.0.a1 Prupe.8G018400_v2.0.a1 Prupe.8G018400_v2.0.a1 Prupe.8G018600_v2.0.a1 Prupe.8G207100_v2.0.a1 Prupe.8G207400_v2.0.a1
pyrus_communis	pycom05g00790 pycom05g16630 pycom10g00850 pycom10g00860 pycom10g00890
rosa_chinensis	RchiOBHm_Chr1g0331561 RchiOBHm_Chr6g0277181 RchiOBHm_Chr6g0277231 RchiOBHm_Chr6g0277261 RchiOBHm_Chr6g0277281 RchiOBHm_Chr6g0277311 RchiOBHm_Chr6g0277321
rosa_laevigata	RLG00000013310 RLG00000013311 RLG00000013312 RLG00000013313 RLG00000013319 RLG00000013325
rosa_multiflora	Rmu_co8243651.1_g000001 Rmu_sc0000030.1_g000028 Rmu_sc0000030.1_g000031 Rmu_sc0000030.1_g000035
rosa_roxburghii	Rroxscaffold_4G00319070 Rroxscaffold_7G00191450 Rroxscaffold_7G00191460 Rroxscaffold_7G00191470 Rroxscaffold_7G00191540
rosa_rugosa	Rorug01G0094000 Rorug01G0094100 Rorug06G0107000 Rorug06G0107100
rosa_samantha	Rh1BG090100 Rh1CG113500 Rh6BG221900 Rh6DG214200 Rh6DG214400 Rh6DG214700 Rh6DG214900
rosa_wichuraiana	Rw6G019010 Rw6G019020 Rw6G019030 Rw6G019040 Rw6G019080

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
Acc16I	TGCGCA	1 cut(s)	313
Acc65I	GGTACC	1 cut(s)	440
AccB1I	GGYRCC	2 cut(s)	94, 440
AccI	GTMKAC	1 cut(s)	159
AciI	CCGC	6 cut(s)	44, 68, 537, 638, 988, 1132
AclWI	GGATC	2 cut(s)	121, 677
AcoI	YGGCCR	1 cut(s)	391
AcsI	RAATTY	3 cut(s)	540, 731, 1046
AfaI	GTAC	9 cut(s)	13, 117, 376, 442, 547, 885, 964, 1019, 1097
AfiI	CCNNNNNNNGG	3 cut(s)	136, 587, 703
AflIII	ACRYGT	2 cut(s)	339, 472
AgsI	TTSAA	5 cut(s)	124, 666, 854, 919, 943
AjnI	CCWGG	2 cut(s)	50, 831
AluBI	AGCT	4 cut(s)	41, 59, 218, 779
AluI	AGCT	4 cut(s)	41, 59, 218, 779
Alw21I	GWGCWC	1 cut(s)	821
Alw26I	GTCTC	1 cut(s)	264
Alw44I	GTGCAC	1 cut(s)	817
AlwI	GGATC	2 cut(s)	121, 677
AoxI	GGCC	1 cut(s)	391
ApaLI	GTGCAC	1 cut(s)	817
ApeKI	GCWGC	4 cut(s)	41, 503, 632, 635
ApoI	RAATTY	3 cut(s)	540, 731, 1046
AseI	ATTAAT	1 cut(s)	360
Asp700I	GAANNNNTTC	1 cut(s)	858
Asp718I	GGTACC	1 cut(s)	440
AspLEI	GCGC	2 cut(s)	314, 508
AsuC2I	CCSGG	3 cut(s)	267, 284, 400
AsuHPI	GGTGA	5 cut(s)	37, 254, 283, 736, 784
AxyI	CCTNAGG	1 cut(s)	353
BaeGI	GKGCMC	1 cut(s)	821
BalI	TGGCCA	1 cut(s)	393
BanI	GGYRCC	2 cut(s)	94, 440
Bbv12I	GWGCWC	1 cut(s)	821
BbvI	GCAGC	4 cut(s)	28, 515, 619, 622
BccI	CCATC	5 cut(s)	383, 407, 860, 933, 1027
BceAI	ACGGC	1 cut(s)	153
BciT130I	CCWGG	2 cut(s)	52, 833
BclI	TGATCA	1 cut(s)	27
BcnI	CCSGG	3 cut(s)	267, 284, 400
BcoDI	GTCTC	1 cut(s)	264
BfmI	CTRYAG	1 cut(s)	501
BfoI	RGCGCY	1 cut(s)	509
BisI	GCNGC	5 cut(s)	42, 68, 504, 633, 636
BlsI	GCNGC	5 cut(s)	43, 69, 505, 634, 637
BmcAI	AGTACT	1 cut(s)	13
Bme1390I	CCNGG	5 cut(s)	52, 267, 284, 400, 833
BmiI	GGNNCC	3 cut(s)	96, 442, 481
BmrFI	CCNGG	5 cut(s)	52, 267, 284, 400, 833
BmsI	GCATC	3 cut(s)	837, 901, 1134
BpmI	CTGGAG	1 cut(s)	240
BpuMI	CCSGG	3 cut(s)	267, 284, 400
BsaI	GGTCTC	1 cut(s)	264
BsaJI	CCNNGG	3 cut(s)	51, 197, 408
BsaWI	WCCGGW	2 cut(s)	293, 1119
BsaXI	ACNNNNNCTCC	6 cut(s)	213, 243, 261, 291, 867, 897
Bsc4I	CCNNNNNNNGG	3 cut(s)	136, 587, 703
Bse1I	ACTGG	1 cut(s)	826
Bse21I	CCTNAGG	1 cut(s)	353
BseBI	CCWGG	2 cut(s)	52, 833
BseDI	CCNNGG	3 cut(s)	51, 197, 408
BseGI	GGATG	4 cut(s)	418, 828, 925, 1128
BseLI	CCNNNNNNNGG	3 cut(s)	136, 587, 703
BseMII	CTCAG	2 cut(s)	771, 1065
BseNI	ACTGG	1 cut(s)	826
BseSI	GKGCMC	1 cut(s)	821
BseXI	GCAGC	4 cut(s)	28, 515, 619, 622
BseYI	CCCAGC	1 cut(s)	59
BshFI	GGCC	1 cut(s)	393
BshNI	GGYRCC	2 cut(s)	94, 440
BsiHKAI	GWGCWC	1 cut(s)	821
BsiSI	CCGG	5 cut(s)	266, 284, 294, 400, 1120
BslFI	GGGAC	1 cut(s)	192
BslI	CCNNNNNNNGG	3 cut(s)	136, 587, 703
BsmAI	GTCTC	1 cut(s)	264
BsmFI	GGGAC	1 cut(s)	192
BsmI	GAATGC	1 cut(s)	305
BsnI	GGCC	1 cut(s)	393
Bso31I	GGTCTC	1 cut(s)	264
Bsp1286I	GDGCHC	1 cut(s)	821
Bsp1407I	TGTACA	1 cut(s)	545
BspACI	CCGC	6 cut(s)	44, 68, 537, 638, 988, 1132
BspANI	GGCC	1 cut(s)	393
BspCNI	CTCAG	2 cut(s)	772, 1066
BspHI	TCATGA	2 cut(s)	211, 862
BspLI	GGNNCC	3 cut(s)	96, 442, 481
BspMAI	CTGCAG	1 cut(s)	505
BspPI	GGATC	2 cut(s)	121, 677
BspT107I	GGYRCC	2 cut(s)	94, 440
BspTNI	GGTCTC	1 cut(s)	264
BsrGI	TGTACA	1 cut(s)	545
BsrI	ACTGG	1 cut(s)	826
BssECI	CCNNGG	3 cut(s)	51, 197, 408
BssNAI	GTATAC	1 cut(s)	160
BssT1I	CCWWGG	1 cut(s)	408
Bst1107I	GTATAC	1 cut(s)	160
Bst2UI	CCWGG	2 cut(s)	52, 833
Bst4CI	ACNGT	4 cut(s)	11, 192, 466, 565
BstAPI	GCANNNNNTGC	1 cut(s)	309
BstAUI	TGTACA	1 cut(s)	545
BstC8I	GCNNGC	2 cut(s)	19, 1104
BstDEI	CTNAG	4 cut(s)	353, 530, 780, 1074
BstF5I	GGATG	4 cut(s)	418, 828, 925, 1128
BstH2I	RGCGCY	1 cut(s)	509
BstHHI	GCGC	2 cut(s)	314, 508
BstMAI	GTCTC	1 cut(s)	264
BstMWI	GCNNNNNNNGC	6 cut(s)	47, 56, 309, 644, 825, 1131
BstNI	CCWGG	2 cut(s)	52, 833
BstNSI	RCATGY	3 cut(s)	343, 476, 1102
BstSCI	CCNGG	5 cut(s)	50, 265, 282, 398, 831
BstSFI	CTRYAG	1 cut(s)	501
BstSLI	GKGCMC	1 cut(s)	821
BstV1I	GCAGC	4 cut(s)	28, 515, 619, 622
BstX2I	RGATCY	1 cut(s)	126
BstYI	RGATCY	1 cut(s)	126
BstZ17I	GTATAC	1 cut(s)	160
Bsu36I	CCTNAGG	1 cut(s)	353
BsuRI	GGCC	1 cut(s)	393
BtsCI	GGATG	4 cut(s)	418, 828, 925, 1128
BtsIMutI	CAGTG	5 cut(s)	150, 188, 460, 462, 819
Cac8I	GCNNGC	2 cut(s)	19, 1104
CciI	TCATGA	2 cut(s)	211, 862
CfoI	GCGC	2 cut(s)	314, 508
Csp6I	GTAC	9 cut(s)	12, 116, 375, 441, 546, 884, 963, 1018, 1096
CviAII	CATG	9 cut(s)	110, 212, 275, 340, 473, 863, 1021, 1099, 1135
CviQI	GTAC	9 cut(s)	12, 116, 375, 441, 546, 884, 963, 1018, 1096
DdeI	CTNAG	4 cut(s)	353, 530, 780, 1074
EaeI	YGGCCR	1 cut(s)	391
Eco130I	CCWWGG	1 cut(s)	408
Eco31I	GGTCTC	1 cut(s)	264
Eco81I	CCTNAGG	1 cut(s)	353
EcoRII	CCWGG	2 cut(s)	50, 831
EcoT14I	CCWWGG	1 cut(s)	408
ErhI	CCWWGG	1 cut(s)	408
FaeI	CATG	9 cut(s)	113, 215, 278, 343, 476, 866, 1024, 1102, 1138
FalI	AAGNNNNNCTT	2 cut(s)	116, 148
FaqI	GGGAC	1 cut(s)	192
FatI	CATG	9 cut(s)	109, 211, 274, 339, 472, 862, 1020, 1098, 1134
FauI	CCCGC	1 cut(s)	995
FbaI	TGATCA	1 cut(s)	27
FblI	GTMKAC	1 cut(s)	159
Fnu4HI	GCNGC	5 cut(s)	42, 68, 504, 633, 636
FokI	GGATG	4 cut(s)	425, 815, 912, 1115
Fsp4HI	GCNGC	5 cut(s)	42, 68, 504, 633, 636
FspAI	RTGCGCAY	1 cut(s)	313
FspI	TGCGCA	1 cut(s)	313
GlaI	GCGC	2 cut(s)	313, 507
GluI	GCNGC	5 cut(s)	42, 68, 504, 633, 636
GsaI	CCCAGC	1 cut(s)	63
GsuI	CTGGAG	1 cut(s)	240
HaeII	RGCGCY	1 cut(s)	509
HaeIII	GGCC	1 cut(s)	393
HapII	CCGG	5 cut(s)	266, 284, 294, 400, 1120
HhaI	GCGC	2 cut(s)	314, 508
Hin1II	CATG	9 cut(s)	113, 215, 278, 343, 476, 866, 1024, 1102, 1138
Hin6I	GCGC	2 cut(s)	312, 506
HinP1I	GCGC	2 cut(s)	312, 506
HinfI	GANTC	4 cut(s)	225, 739, 952, 1116
HpaII	CCGG	5 cut(s)	266, 284, 294, 400, 1120
HphI	GGTGA	5 cut(s)	37, 254, 283, 736, 784
Hpy166II	GTNNAC	3 cut(s)	160, 291, 819
Hpy188I	TCNGA	6 cut(s)	201, 328, 611, 687, 930, 1075
Hpy188III	TCNNGA	5 cut(s)	212, 512, 767, 863, 940
Hpy8I	GTNNAC	3 cut(s)	160, 291, 819
HpyAV	CCTTC	1 cut(s)	635
HpyCH4III	ACNGT	4 cut(s)	11, 192, 466, 565
HpyCH4V	TGCA	8 cut(s)	36, 303, 503, 575, 602, 647, 819, 1125
HpyF10VI	GCNNNNNNNGC	6 cut(s)	47, 56, 309, 644, 825, 1131
HpyF3I	CTNAG	4 cut(s)	353, 530, 780, 1074
Hsp92II	CATG	9 cut(s)	113, 215, 278, 343, 476, 866, 1024, 1102, 1138
HspAI	GCGC	2 cut(s)	312, 506
KpnI	GGTACC	1 cut(s)	444
Ksp22I	TGATCA	1 cut(s)	27
LmnI	GCTCC	1 cut(s)	1138
Lsp1109I	GCAGC	4 cut(s)	28, 515, 619, 622
LweI	GCATC	3 cut(s)	837, 901, 1134
MaeIII	GTNAC	2 cut(s)	250, 974
MboII	GAAGA	2 cut(s)	136, 502
MflI	RGATCY	1 cut(s)	126
MhlI	GDGCHC	1 cut(s)	821
MlsI	TGGCCA	1 cut(s)	393
MluCI	AATT	6 cut(s)	423, 540, 603, 731, 1037, 1046
MluNI	TGGCCA	1 cut(s)	393
MlyI	GAGTC	1 cut(s)	946
MmeI	TCCRAC	4 cut(s)	30, 286, 717, 871
Mox20I	TGGCCA	1 cut(s)	393
MroXI	GAANNNNTTC	1 cut(s)	858
MscI	TGGCCA	1 cut(s)	393
MseI	TTAA	1 cut(s)	360
MslI	CAYNNNNRTG	2 cut(s)	153, 1133
Msp20I	TGGCCA	1 cut(s)	393
MspA1I	CMGCKG	1 cut(s)	70
MspI	CCGG	5 cut(s)	266, 284, 294, 400, 1120
MspR9I	CCNGG	5 cut(s)	52, 267, 284, 400, 833
Mva1269I	GAATGC	1 cut(s)	305
MvaI	CCWGG	2 cut(s)	52, 833
MwoI	GCNNNNNNNGC	6 cut(s)	47, 56, 309, 644, 825, 1131
NciI	CCSGG	3 cut(s)	267, 284, 400
NlaIII	CATG	9 cut(s)	113, 215, 278, 343, 476, 866, 1024, 1102, 1138
NlaIV	GGNNCC	3 cut(s)	96, 442, 481
NsbI	TGCGCA	1 cut(s)	313
NspI	RCATGY	3 cut(s)	343, 476, 1102
PagI	TCATGA	2 cut(s)	211, 862
PciI	ACATGT	2 cut(s)	339, 472
PcsI	WCGNNNNNNNCGW	1 cut(s)	234
PctI	GAATGC	1 cut(s)	305
PdmI	GAANNNNTTC	1 cut(s)	858
PfeI	GAWTC	3 cut(s)	225, 739, 1116
PflFI	GACNNNGTC	1 cut(s)	275
PkrI	GCNGC	5 cut(s)	43, 69, 505, 634, 637
PleI	GAGTC	1 cut(s)	946
PpsI	GAGTC	1 cut(s)	946
PscI	ACATGT	2 cut(s)	339, 472
PshBI	ATTAAT	1 cut(s)	360
Psp6I	CCWGG	2 cut(s)	50, 831
PspFI	CCCAGC	1 cut(s)	59
PspGI	CCWGG	2 cut(s)	50, 831
PspN4I	GGNNCC	3 cut(s)	96, 442, 481
PstI	CTGCAG	1 cut(s)	505
PsuI	RGATCY	1 cut(s)	126
PsyI	GACNNNGTC	1 cut(s)	275
RsaI	GTAC	9 cut(s)	13, 117, 376, 442, 547, 885, 964, 1019, 1097
RsaNI	GTAC	9 cut(s)	12, 116, 375, 441, 546, 884, 963, 1018, 1096
RseI	CAYNNNNRTG	2 cut(s)	153, 1133
SaqAI	TTAA	1 cut(s)	360
SatI	GCNGC	5 cut(s)	42, 68, 504, 633, 636
ScaI	AGTACT	1 cut(s)	13
SchI	GAGTC	1 cut(s)	946
ScrFI	CCNGG	5 cut(s)	52, 267, 284, 400, 833
SduI	GDGCHC	1 cut(s)	821
SfaNI	GCATC	3 cut(s)	837, 901, 1134
SfcI	CTRYAG	1 cut(s)	501
SmiMI	CAYNNNNRTG	2 cut(s)	153, 1133
Sse9I	AATT	6 cut(s)	423, 540, 603, 731, 1037, 1046
SsiI	CCGC	6 cut(s)	44, 68, 537, 638, 988, 1132
StyD4I	CCNGG	5 cut(s)	50, 265, 282, 398, 831
StyI	CCWWGG	1 cut(s)	408
TaaI	ACNGT	4 cut(s)	11, 192, 466, 565
TasI	AATT	6 cut(s)	423, 540, 603, 731, 1037, 1046
TatI	WGTACW	5 cut(s)	11, 545, 883, 1017, 1095
TauI	GCSGC	1 cut(s)	70
TfiI	GAWTC	3 cut(s)	225, 739, 1116
Tru1I	TTAA	1 cut(s)	360
Tru9I	TTAA	1 cut(s)	360
TscAI	CASTG	5 cut(s)	157, 195, 460, 469, 826
TseI	GCWGC	4 cut(s)	41, 503, 632, 635
TspDTI	ATGAA	7 cut(s)	126, 228, 582, 744, 851, 947, 1037
TspGWI	ACGGA	1 cut(s)	472
TspRI	CASTG	5 cut(s)	157, 195, 460, 469, 826
Tth111I	GACNNNGTC	1 cut(s)	275
VneI	GTGCAC	1 cut(s)	817
VspI	ATTAAT	1 cut(s)	360
XapI	RAATTY	3 cut(s)	540, 731, 1046
XceI	RCATGY	3 cut(s)	343, 476, 1102
XmiI	GTMKAC	1 cut(s)	159
XmnI	GAANNNNTTC	1 cut(s)	858
ZrmI	AGTACT	1 cut(s)	13

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.