MAP kinase kinase kinase activity
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| Pkinase | PF00069 | 15 - 264 | 9.3e-64 | Protein kinase domain |
| PK_Tyr_Ser-Thr | PF07714 | 17 - 260 | 4.2e-38 | Protein tyrosine and serine/threonine kinase |
| ABC1 | PF03109 | 49 - 157 | 3e-06 | ABC1 atypical kinase-like domain |
| Pkinase | PF00069 | 363 - 627 | 8.8e-48 | Protein kinase domain |
| PK_Tyr_Ser-Thr | PF07714 | 365 - 626 | 3.8e-48 | Protein tyrosine and serine/threonine kinase |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 1131 |
| AasI | GACNNNNNNGTC | 1 cut(s) | 670 |
| AccB7I | CCANNNNNTGG | 1 cut(s) | 932 |
| AccI | GTMKAC | 1 cut(s) | 1641 |
| AccII | CGCG | 1 cut(s) | 1838 |
| AccIII | TCCGGA | 1 cut(s) | 107 |
| AciI | CCGC | 6 cut(s) | 635, 762, 936, 1287, 1677, 1838 |
| AclWI | GGATC | 5 cut(s) | 258, 271, 301, 1760, 1773 |
| AcoI | YGGCCR | 1 cut(s) | 76 |
| AcuI | CTGAAG | 1 cut(s) | 546 |
| AfaI | GTAC | 4 cut(s) | 255, 505, 1310, 1604 |
| AfiI | CCNNNNNNNGG | 3 cut(s) | 500, 932, 1040 |
| AflII | CTTAAG | 1 cut(s) | 776 |
| AhlI | ACTAGT | 1 cut(s) | 1759 |
| AjnI | CCWGG | 1 cut(s) | 256 |
| AjuI | GAANNNNNNNTTGG | 4 cut(s) | 598, 630, 1086, 1118 |
| AluBI | AGCT | 4 cut(s) | 115, 315, 1053, 1163 |
| AluI | AGCT | 4 cut(s) | 115, 315, 1053, 1163 |
| Alw26I | GTCTC | 4 cut(s) | 12, 678, 1216, 1544 |
| AlwI | GGATC | 5 cut(s) | 258, 271, 301, 1760, 1773 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 308 |
| Ama87I | CYCGRG | 1 cut(s) | 1598 |
| Aor13HI | TCCGGA | 1 cut(s) | 107 |
| AoxI | GGCC | 4 cut(s) | 69, 76, 755, 1859 |
| ApeKI | GCWGC | 3 cut(s) | 122, 473, 707 |
| AspLEI | GCGC | 2 cut(s) | 438, 1838 |
| AspS9I | GGNCC | 5 cut(s) | 69, 1031, 1121, 1860, 1976 |
| AsuC2I | CCSGG | 1 cut(s) | 67 |
| AsuHPI | GGTGA | 2 cut(s) | 331, 1156 |
| AvaI | CYCGRG | 1 cut(s) | 1598 |
| AvaII | GGWCC | 3 cut(s) | 1031, 1121, 1976 |
| BamHI | GGATCC | 2 cut(s) | 263, 1765 |
| BbvI | GCAGC | 3 cut(s) | 109, 485, 719 |
| BccI | CCATC | 2 cut(s) | 511, 766 |
| BceAI | ACGGC | 3 cut(s) | 63, 1717, 1742 |
| BciT130I | CCWGG | 1 cut(s) | 258 |
| BciVI | GTATCC | 1 cut(s) | 928 |
| BclI | TGATCA | 1 cut(s) | 691 |
| BcnI | CCSGG | 1 cut(s) | 67 |
| BcoDI | GTCTC | 4 cut(s) | 12, 678, 1216, 1544 |
| BcuI | ACTAGT | 1 cut(s) | 1759 |
| BfaI | CTAG | 7 cut(s) | 362, 446, 942, 1367, 1760, 1935, 1959 |
| BfmI | CTRYAG | 4 cut(s) | 558, 705, 822, 1642 |
| BfrI | CTTAAG | 1 cut(s) | 776 |
| BfuI | GTATCC | 1 cut(s) | 928 |
| BisI | GCNGC | 3 cut(s) | 123, 474, 708 |
| BlsI | GCNGC | 3 cut(s) | 124, 475, 709 |
| Bme1390I | CCNGG | 2 cut(s) | 67, 258 |
| Bme18I | GGWCC | 3 cut(s) | 1031, 1121, 1976 |
| BmeT110I | CYCGRG | 1 cut(s) | 1598 |
| BmgT120I | GGNCC | 5 cut(s) | 69, 1031, 1121, 1860, 1976 |
| BmiI | GGNNCC | 9 cut(s) | 64, 70, 211, 265, 522, 620, 744, 964, 1767 |
| BmrFI | CCNGG | 2 cut(s) | 67, 258 |
| BmrI | ACTGGG | 1 cut(s) | 804 |
| BmuI | ACTGGG | 1 cut(s) | 804 |
| BpmI | CTGGAG | 2 cut(s) | 279, 1420 |
| BpuEI | CTTGAG | 1 cut(s) | 1392 |
| BpuMI | CCSGG | 1 cut(s) | 67 |
| BsaJI | CCNNGG | 3 cut(s) | 66, 141, 614 |
| BsaWI | WCCGGW | 3 cut(s) | 107, 1148, 1978 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 1418, 1448 |
| Bsc4I | CCNNNNNNNGG | 3 cut(s) | 500, 932, 1040 |
| Bse118I | RCCGGY | 1 cut(s) | 1857 |
| Bse1I | ACTGG | 8 cut(s) | 518, 547, 607, 799, 1353, 1470, 1488, 1779 |
| BseAI | TCCGGA | 1 cut(s) | 107 |
| BseBI | CCWGG | 1 cut(s) | 258 |
| BseDI | CCNNGG | 3 cut(s) | 66, 141, 614 |
| BseLI | CCNNNNNNNGG | 3 cut(s) | 500, 932, 1040 |
| BseMII | CTCAG | 5 cut(s) | 315, 759, 827, 1080, 1211 |
| BseNI | ACTGG | 8 cut(s) | 518, 547, 607, 799, 1353, 1470, 1488, 1779 |
| BseXI | GCAGC | 3 cut(s) | 109, 485, 719 |
| BsgI | GTGCAG | 3 cut(s) | 707, 977, 1767 |
| Bsh1236I | CGCG | 1 cut(s) | 1838 |
| BshFI | GGCC | 4 cut(s) | 71, 78, 757, 1861 |
| BsiHKCI | CYCGRG | 1 cut(s) | 1598 |
| BsiSI | CCGG | 5 cut(s) | 66, 108, 1149, 1858, 1979 |
| BslFI | GGGAC | 5 cut(s) | 410, 553, 676, 905, 1591 |
| BslI | CCNNNNNNNGG | 3 cut(s) | 500, 932, 1040 |
| BsmAI | GTCTC | 4 cut(s) | 12, 678, 1216, 1544 |
| BsmBI | CGTCTC | 2 cut(s) | 12, 1544 |
| BsmFI | GGGAC | 5 cut(s) | 410, 553, 676, 905, 1591 |
| BsmI | GAATGC | 1 cut(s) | 1275 |
| BsnI | GGCC | 4 cut(s) | 71, 78, 757, 1861 |
| BsoBI | CYCGRG | 1 cut(s) | 1598 |
| Bsp13I | TCCGGA | 1 cut(s) | 107 |
| Bsp143I | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| BspACI | CCGC | 6 cut(s) | 635, 762, 936, 1287, 1677, 1838 |
| BspANI | GGCC | 4 cut(s) | 71, 78, 757, 1861 |
| BspCNI | CTCAG | 5 cut(s) | 314, 760, 826, 1081, 1212 |
| BspEI | TCCGGA | 1 cut(s) | 107 |
| BspFNI | CGCG | 1 cut(s) | 1838 |
| BspHI | TCATGA | 1 cut(s) | 547 |
| BspLI | GGNNCC | 9 cut(s) | 64, 70, 211, 265, 522, 620, 744, 964, 1767 |
| BspMAI | CTGCAG | 3 cut(s) | 562, 709, 826 |
| BspPI | GGATC | 5 cut(s) | 258, 271, 301, 1760, 1773 |
| BspTI | CTTAAG | 1 cut(s) | 776 |
| BsrFI | RCCGGY | 1 cut(s) | 1857 |
| BsrI | ACTGG | 8 cut(s) | 518, 547, 607, 799, 1353, 1470, 1488, 1779 |
| BssAI | RCCGGY | 1 cut(s) | 1857 |
| BssECI | CCNNGG | 3 cut(s) | 66, 141, 614 |
| BssMI | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| BssT1I | CCWWGG | 2 cut(s) | 141, 614 |
| Bst2UI | CCWGG | 1 cut(s) | 258 |
| Bst4CI | ACNGT | 8 cut(s) | 586, 627, 751, 1555, 1646, 1806, 1943, 2015 |
| Bst6I | CTCTTC | 1 cut(s) | 1542 |
| BstAFI | CTTAAG | 1 cut(s) | 776 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 352 |
| BstC8I | GCNNGC | 2 cut(s) | 357, 1926 |
| BstDEI | CTNAG | 5 cut(s) | 301, 768, 813, 1089, 1220 |
| BstEII | GGTNACC | 1 cut(s) | 1144 |
| BstFNI | CGCG | 1 cut(s) | 1838 |
| BstHHI | GCGC | 2 cut(s) | 438, 1838 |
| BstKTI | GATC | 5 cut(s) | 60, 266, 296, 694, 1768 |
| BstMAI | GTCTC | 4 cut(s) | 12, 678, 1216, 1544 |
| BstMBI | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 131, 352, 579, 1735 |
| BstNI | CCWGG | 1 cut(s) | 258 |
| BstNSI | RCATGY | 2 cut(s) | 889, 1594 |
| BstPI | GGTNACC | 1 cut(s) | 1144 |
| BstSCI | CCNGG | 2 cut(s) | 65, 256 |
| BstSFI | CTRYAG | 4 cut(s) | 558, 705, 822, 1642 |
| BstUI | CGCG | 1 cut(s) | 1838 |
| BstV1I | GCAGC | 3 cut(s) | 109, 485, 719 |
| BstX2I | RGATCY | 3 cut(s) | 263, 293, 1765 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 1343 |
| BstYI | RGATCY | 3 cut(s) | 263, 293, 1765 |
| BsuI | GTATCC | 1 cut(s) | 928 |
| BsuRI | GGCC | 4 cut(s) | 71, 78, 757, 1861 |
| BtsIMutI | CAGTG | 3 cut(s) | 582, 600, 1360 |
| Cac8I | GCNNGC | 2 cut(s) | 357, 1926 |
| CaiI | CAGNNNCTG | 1 cut(s) | 308 |
| CciI | TCATGA | 1 cut(s) | 547 |
| CfoI | GCGC | 2 cut(s) | 438, 1838 |
| Cfr10I | RCCGGY | 1 cut(s) | 1857 |
| Cfr13I | GGNCC | 5 cut(s) | 69, 1031, 1121, 1860, 1976 |
| Csp6I | GTAC | 4 cut(s) | 254, 504, 1309, 1603 |
| CviQI | GTAC | 4 cut(s) | 254, 504, 1309, 1603 |
| DdeI | CTNAG | 5 cut(s) | 301, 768, 813, 1089, 1220 |
| DpnI | GATC | 5 cut(s) | 59, 265, 295, 693, 1767 |
| DpnII | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| DraI | TTTAAA | 2 cut(s) | 994, 1329 |
| DrdI | GACNNNNNNGTC | 1 cut(s) | 670 |
| DseDI | GACNNNNNNGTC | 1 cut(s) | 670 |
| EaeI | YGGCCR | 1 cut(s) | 76 |
| Eam1104I | CTCTTC | 1 cut(s) | 1542 |
| EarI | CTCTTC | 1 cut(s) | 1542 |
| EciI | GGCGGA | 2 cut(s) | 951, 1302 |
| Eco130I | CCWWGG | 2 cut(s) | 141, 614 |
| Eco32I | GATATC | 1 cut(s) | 1881 |
| Eco47I | GGWCC | 3 cut(s) | 1031, 1121, 1976 |
| Eco57I | CTGAAG | 1 cut(s) | 546 |
| Eco88I | CYCGRG | 1 cut(s) | 1598 |
| Eco91I | GGTNACC | 1 cut(s) | 1144 |
| EcoO109I | RGGNCCY | 1 cut(s) | 69 |
| EcoO65I | GGTNACC | 1 cut(s) | 1144 |
| EcoRI | GAATTC | 1 cut(s) | 817 |
| EcoRII | CCWGG | 1 cut(s) | 256 |
| EcoRV | GATATC | 1 cut(s) | 1881 |
| EcoT14I | CCWWGG | 2 cut(s) | 141, 614 |
| EcoT22I | ATGCAT | 1 cut(s) | 1817 |
| ErhI | CCWWGG | 2 cut(s) | 141, 614 |
| Esp3I | CGTCTC | 2 cut(s) | 12, 1544 |
| FalI | AAGNNNNNCTT | 4 cut(s) | 150, 182, 1037, 1069 |
| FaqI | GGGAC | 5 cut(s) | 410, 553, 676, 905, 1591 |
| FbaI | TGATCA | 1 cut(s) | 691 |
| FblI | GTMKAC | 1 cut(s) | 1641 |
| Fnu4HI | GCNGC | 3 cut(s) | 123, 474, 708 |
| Fsp4HI | GCNGC | 3 cut(s) | 123, 474, 708 |
| FspBI | CTAG | 7 cut(s) | 362, 446, 942, 1367, 1760, 1935, 1959 |
| GlaI | GCGC | 2 cut(s) | 437, 1837 |
| GluI | GCNGC | 3 cut(s) | 123, 474, 708 |
| GsuI | CTGGAG | 2 cut(s) | 279, 1420 |
| HaeIII | GGCC | 4 cut(s) | 71, 78, 757, 1861 |
| HapII | CCGG | 5 cut(s) | 66, 108, 1149, 1858, 1979 |
| HhaI | GCGC | 2 cut(s) | 438, 1838 |
| Hin6I | GCGC | 2 cut(s) | 436, 1836 |
| HinP1I | GCGC | 2 cut(s) | 436, 1836 |
| HindIII | AAGCTT | 1 cut(s) | 313 |
| HinfI | GANTC | 6 cut(s) | 34, 104, 384, 809, 1224, 1498 |
| HpaII | CCGG | 5 cut(s) | 66, 108, 1149, 1858, 1979 |
| HphI | GGTGA | 2 cut(s) | 331, 1156 |
| Hpy166II | GTNNAC | 5 cut(s) | 85, 506, 1420, 1642, 2039 |
| Hpy188I | TCNGA | 9 cut(s) | 189, 769, 816, 871, 1090, 1260, 1873, 1950, 2029 |
| Hpy188III | TCNNGA | 8 cut(s) | 108, 152, 524, 548, 1011, 1437, 1598, 1935 |
| Hpy8I | GTNNAC | 5 cut(s) | 85, 506, 1420, 1642, 2039 |
| HpyAV | CCTTC | 3 cut(s) | 40, 1033, 1391 |
| HpyCH4III | ACNGT | 8 cut(s) | 586, 627, 751, 1555, 1646, 1806, 1943, 2015 |
| HpyCH4IV | ACGT | 1 cut(s) | 2041 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 131, 352, 579, 1735 |
| HpyF3I | CTNAG | 5 cut(s) | 301, 768, 813, 1089, 1220 |
| HpySE526I | ACGT | 1 cut(s) | 2041 |
| HspAI | GCGC | 2 cut(s) | 436, 1836 |
| Kpn2I | TCCGGA | 1 cut(s) | 107 |
| Ksp22I | TGATCA | 1 cut(s) | 691 |
| Kzo9I | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| LmnI | GCTCC | 4 cut(s) | 407, 526, 570, 962 |
| Lsp1109I | GCAGC | 3 cut(s) | 109, 485, 719 |
| MaeI | CTAG | 7 cut(s) | 362, 446, 942, 1367, 1760, 1935, 1959 |
| MaeII | ACGT | 1 cut(s) | 2041 |
| MaeIII | GTNAC | 4 cut(s) | 1144, 1355, 1586, 1679 |
| MalI | GATC | 5 cut(s) | 59, 265, 295, 693, 1767 |
| MboI | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| MboII | GAAGA | 6 cut(s) | 1026, 1176, 1302, 1559, 1853, 1862 |
| MflI | RGATCY | 3 cut(s) | 263, 293, 1765 |
| MlyI | GAGTC | 1 cut(s) | 1218 |
| MmeI | TCCRAC | 3 cut(s) | 225, 556, 1264 |
| Mph1103I | ATGCAT | 1 cut(s) | 1817 |
| MroI | TCCGGA | 1 cut(s) | 107 |
| MslI | CAYNNNNRTG | 1 cut(s) | 92 |
| MspCI | CTTAAG | 1 cut(s) | 776 |
| MspI | CCGG | 5 cut(s) | 66, 108, 1149, 1858, 1979 |
| MspR9I | CCNGG | 2 cut(s) | 67, 258 |
| MssI | GTTTAAAC | 1 cut(s) | 1329 |
| Mva1269I | GAATGC | 1 cut(s) | 1275 |
| MvaI | CCWGG | 1 cut(s) | 258 |
| MvnI | CGCG | 1 cut(s) | 1838 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 131, 352, 579, 1735 |
| NciI | CCSGG | 1 cut(s) | 67 |
| NdeII | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| NlaIV | GGNNCC | 9 cut(s) | 64, 70, 211, 265, 522, 620, 744, 964, 1767 |
| NmuCI | GTSAC | 2 cut(s) | 1144, 1355 |
| NsiI | ATGCAT | 1 cut(s) | 1817 |
| NspI | RCATGY | 2 cut(s) | 889, 1594 |
| PagI | TCATGA | 1 cut(s) | 547 |
| PctI | GAATGC | 1 cut(s) | 1275 |
| PfeI | GAWTC | 5 cut(s) | 34, 104, 384, 809, 1498 |
| PflMI | CCANNNNNTGG | 1 cut(s) | 932 |
| PkrI | GCNGC | 3 cut(s) | 124, 475, 709 |
| PleI | GAGTC | 1 cut(s) | 1218 |
| PmeI | GTTTAAAC | 1 cut(s) | 1329 |
| PpsI | GAGTC | 1 cut(s) | 1218 |
| PsiI | TTATAA | 1 cut(s) | 1131 |
| Psp6I | CCWGG | 1 cut(s) | 256 |
| PspEI | GGTNACC | 1 cut(s) | 1144 |
| PspGI | CCWGG | 1 cut(s) | 256 |
| PspN4I | GGNNCC | 9 cut(s) | 64, 70, 211, 265, 522, 620, 744, 964, 1767 |
| PspPI | GGNCC | 5 cut(s) | 69, 1031, 1121, 1860, 1976 |
| PstI | CTGCAG | 3 cut(s) | 562, 709, 826 |
| PstNI | CAGNNNCTG | 1 cut(s) | 308 |
| PsuI | RGATCY | 3 cut(s) | 263, 293, 1765 |
| RsaI | GTAC | 4 cut(s) | 255, 505, 1310, 1604 |
| RsaNI | GTAC | 4 cut(s) | 254, 504, 1309, 1603 |
| RseI | CAYNNNNRTG | 1 cut(s) | 92 |
| SatI | GCNGC | 3 cut(s) | 123, 474, 708 |
| Sau3AI | GATC | 5 cut(s) | 57, 263, 293, 691, 1765 |
| Sau96I | GGNCC | 5 cut(s) | 69, 1031, 1121, 1860, 1976 |
| SchI | GAGTC | 1 cut(s) | 1218 |
| ScrFI | CCNGG | 2 cut(s) | 67, 258 |
| SfcI | CTRYAG | 4 cut(s) | 558, 705, 822, 1642 |
| SinI | GGWCC | 3 cut(s) | 1031, 1121, 1976 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 92 |
| SmlI | CTYRAG | 2 cut(s) | 776, 1407 |
| SmoI | CTYRAG | 2 cut(s) | 776, 1407 |
| SpeI | ACTAGT | 1 cut(s) | 1759 |
| SsiI | CCGC | 6 cut(s) | 635, 762, 936, 1287, 1677, 1838 |
| SspI | AATATT | 1 cut(s) | 368 |
| SspMI | CTAG | 7 cut(s) | 362, 446, 942, 1367, 1760, 1935, 1959 |
| StyD4I | CCNGG | 2 cut(s) | 65, 256 |
| StyI | CCWWGG | 2 cut(s) | 141, 614 |
| TaaI | ACNGT | 8 cut(s) | 586, 627, 751, 1555, 1646, 1806, 1943, 2015 |
| TaiI | ACGT | 1 cut(s) | 2044 |
| TaqI | TCGA | 2 cut(s) | 32, 1010 |
| TatI | WGTACW | 1 cut(s) | 1308 |
| TfiI | GAWTC | 5 cut(s) | 34, 104, 384, 809, 1498 |
| TscAI | CASTG | 3 cut(s) | 589, 607, 1360 |
| TseFI | GTSAC | 2 cut(s) | 1144, 1355 |
| TseI | GCWGC | 3 cut(s) | 122, 473, 707 |
| Tsp45I | GTSAC | 2 cut(s) | 1144, 1355 |
| TspGWI | ACGGA | 1 cut(s) | 1580 |
| TspRI | CASTG | 3 cut(s) | 589, 607, 1360 |
| Van91I | CCANNNNNTGG | 1 cut(s) | 932 |
| Vha464I | CTTAAG | 1 cut(s) | 776 |
| VpaK11BI | GGWCC | 3 cut(s) | 1031, 1121, 1976 |
| XbaI | TCTAGA | 1 cut(s) | 1934 |
| XceI | RCATGY | 2 cut(s) | 889, 1594 |
| XmiI | GTMKAC | 1 cut(s) | 1641 |
| XspI | CTAG | 7 cut(s) | 362, 446, 942, 1367, 1760, 1935, 1959 |
| Zsp2I | ATGCAT | 1 cut(s) | 1817 |