Basic Information

Type: gene

Biological Identity

Species

prunus_persica

Chromosome

Pp01

Orthogroup ID

OG0000719

Physical Location & Seq

Genomic Coordinates Forward (+)

1947760 .. 1953157

Gene Structure 5398 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

Prupe.1G027800.1

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1179 bp

ATGGCTCGAGACGGGGAAGTGGTGCCGGTGGACCCACAAGCGGTTGTGGCCGTGAAGAAGAAGTCGTCTCGGAGTTGGGTTTTGCTGGACTGTACGGGAAAAGCTACAGTCTTGGACGTGGACAAGTATGCCATCATGCACAGAGTTCACATTCACGCTCGCGATCTTCGCATTGTCGATCCTTTGCTCTCTTACCCTTCCACCATTCTCGGCCGCGACAGGGCTATAGTTCTCAATTTGGAGCATATTAAAGCAATAATCACTGCCGAAGAGGTGCTGCTTCGGGATCCAGTGGATGAAAATGTTATCCCTGTTGTTGAAGAGCTTCAAAGACGGTTGCCTCCCGTAAATGCCATACATGAAAGCCAAAAAGATGGGAAAGAGTTCCCTGCTGGGCTAATTGATGTAGATGCCGGTGAAGAAGATGAGTCTCCATTTGAGTTCCGGGCCTTGGAGGTAGCTTTGGAAGCAATTTGCAGTTATCTTTCTGCACGTACGACAGAACTGGAGACTGCTGCTTATCCTGCTTTAGATGAGCTTACCTCAAAGATTAGCAGCCGCAATTTGGACAGGGTTCGTAAATTGAAGAGTGCAATGACAAGGTTGACTGCTCGCGTACAAAAGGTAAGGGATGAGCTTGAACAGCTGTTGGATGATGACGATGATATGGCTGACCTTTACTTGTCAAGAAAGTTGGCTGGTGCATCTTCACCAGTTAGTGTCTCTGGTCCTCCCAATTGGTATCCTGCCTCCCCTACCATAGGCTCAAAAATATCTCGGGCAAGTAGAGCAAGCATTGCCACTGTTCGTGGAGATGAGAATGACGTTGAGGAACTTGAAATGTTACTTGAGGCTTATTTTATGCAGATTGATGGCACCTTGAACAAATTAGCTACGCTGCGTGAATATATTGATGATACAGAGGATTATATCAATATTCAGCTTGATAACCACAGGAATCAGCTGATTCAGCTTGAGCTTTTTCTCAGTGCTGGGACTCTATGTATGGCCATATTTTCATTGGTGGCTGGAATTTTTGGCATGAACATCCCTTATACGTGGAATGATGGTTACGGATACATGTTCAAATGGGTTTGCATTGTCACGGGAATAGTCTGTGCTTGTGTGTTCATAATTATCATGTCATATGCTCGCTTCAAGGGGTTGGTCGGGTCGTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0005215 GO:0005575 GO:0005623 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0007275 GO:0008150 GO:0008324 GO:0009555 GO:0015075 GO:0015095 GO:0015318 GO:0015693 GO:0016020 GO:0022857 GO:0022890 GO:0030001 GO:0032501 GO:0032502 GO:0034220 GO:0044464 GO:0046873 GO:0048229 GO:0048856 GO:0051179 GO:0051234 GO:0055085 GO:0070838 GO:0071944 GO:0072511 GO:0098655 GO:0098660 GO:0098662 GO:1903830

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

CorA

Protein Analysis

393

Amino Acids

43.71

Weight (kDa)

4.89

Isoelectric Point (pI)

41.32

Instability Index

Protein Domains (Pfam)

No Pfam domains detected for this protein.

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

Font Size (px)

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0000719)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09690 AT5G09720 AT5G09720 AT5G64560 AT5G64560
fragaria_vesca	FvH4_2g22370 FvH4_2g22370 FvH4_2g22410 FvH4_4g02330 FvH4_4g02330
malus_domestica	MD05G1204800.v1.1 MD10G1191900.v1.1 MD13G1205200.v1.1 MD16G1207000.v1.1
prunus_persica	Prupe.1G027800_v2.0.a1 Prupe.8G231400_v2.0.a1 Prupe.8G231400_v2.0.a1 Prupe.8G231400_v2.0.a1 Prupe.8G231400_v2.0.a1 Prupe.8G231400_v2.0.a1
pyrus_communis	pycom05g19100 pycom10g16560 pycom10g16580 pycom13g17790 pycom16g17380
rosa_chinensis	RchiOBHm_Chr2g0150571 RchiOBHm_Chr4g0389661 RchiOBHm_Chr4g0389711 RchiOBHm_Chr6g0289361
rosa_laevigata	RLG00000009961 RLG00000012309
rosa_multiflora	Rmu_sc0001527.1_g000030 Rmu_sc0005115.1_g000007 Rmu_sc0005697.1_g000020 Rmu_sc0007419.1_g000012
rosa_roxburghii	Rroxscaffold_5G00335660 Rroxscaffold_5G00335700 Rroxscaffold_7G00179320
rosa_rugosa	Rorug03G0310000 Rorug03G0324700 Rorug04G0112800 Rorug04G0112900 Rorug04G0113000
rosa_samantha	Rh4AG029400 Rh4AG029700 Rh4BG022600 Rh4BG022800 Rh4CG031300 Rh4DG023000 Rh5DG350100 Rh6BG321400 Rh6CG327700 Rh6DG313300
rosa_wichuraiana	Rw3G027490 Rw4G002190 Rw4G002220 Rw4G006140 Rw6G003570 Rw6G005340 Rw6G027140

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AccB1I	GGYRCC	2 cut(s)	22, 875
AccII	CGCG	3 cut(s)	162, 216, 615
AciI	CCGC	3 cut(s)	41, 214, 559
AclWI	GGATC	3 cut(s)	173, 281, 294
AcoI	YGGCCR	3 cut(s)	48, 211, 1008
AcsI	RAATTY	1 cut(s)	1032
AfaI	GTAC	3 cut(s)	94, 496, 618
AfiI	CCNNNNNNNGG	5 cut(s)	40, 220, 451, 565, 761
AflIII	ACRYGT	1 cut(s)	1080
AgsI	TTSAA	8 cut(s)	320, 329, 586, 641, 839, 883, 1087, 1159
AjiI	CACGTC	1 cut(s)	118
Alw26I	GTCTC	5 cut(s)	3, 72, 435, 503, 727
AlwI	GGATC	3 cut(s)	173, 281, 294
Ama87I	CYCGRG	2 cut(s)	6, 777
AoxI	GGCC	4 cut(s)	48, 211, 447, 1008
ApeKI	GCWGC	4 cut(s)	277, 515, 555, 898
ApoI	RAATTY	1 cut(s)	1032
Asp700I	GAANNNNTTC	2 cut(s)	324, 383
AspS9I	GGNCC	3 cut(s)	31, 447, 728
AsuC2I	CCSGG	1 cut(s)	446
AsuHPI	GGTGA	2 cut(s)	428, 702
AvaI	CYCGRG	2 cut(s)	6, 777
AvaII	GGWCC	2 cut(s)	31, 728
BalI	TGGCCA	1 cut(s)	1010
BamHI	GGATCC	1 cut(s)	286
BanI	GGYRCC	2 cut(s)	22, 875
BbvI	GCAGC	4 cut(s)	264, 502, 567, 885
BccI	CCATC	4 cut(s)	140, 368, 866, 1061
BceAI	ACGGC	1 cut(s)	35
BciVI	GTATCC	2 cut(s)	753, 1070
BcnI	CCSGG	1 cut(s)	446
BcoDI	GTCTC	5 cut(s)	3, 72, 435, 503, 727
BfmI	CTRYAG	2 cut(s)	105, 225
BfuI	GTATCC	2 cut(s)	753, 1070
BisI	GCNGC	6 cut(s)	214, 278, 516, 556, 559, 899
BlsI	GCNGC	6 cut(s)	215, 279, 517, 557, 560, 900
Bme1390I	CCNGG	1 cut(s)	446
Bme18I	GGWCC	2 cut(s)	31, 728
BmeT110I	CYCGRG	2 cut(s)	6, 777
BmgBI	CACGTC	1 cut(s)	118
BmgT120I	GGNCC	3 cut(s)	31, 447, 728
BmiI	GGNNCC	4 cut(s)	24, 33, 288, 877
BmrFI	CCNGG	1 cut(s)	446
BmsI	GCATC	2 cut(s)	400, 713
BplI	GAGNNNNNCTC	2 cut(s)	527, 559
BpmI	CTGGAG	1 cut(s)	527
BpuEI	CTTGAG	2 cut(s)	869, 995
BpuMI	CCSGG	1 cut(s)	446
BsaAI	YACGTR	2 cut(s)	494, 1059
BsaJI	CCNNGG	1 cut(s)	450
Bsc4I	CCNNNNNNNGG	5 cut(s)	40, 220, 451, 565, 761
Bse118I	RCCGGY	2 cut(s)	25, 413
Bse1I	ACTGG	3 cut(s)	290, 510, 713
Bse3DI	GCAATG	2 cut(s)	600, 795
BseDI	CCNNGG	1 cut(s)	450
BseGI	GGATG	4 cut(s)	301, 637, 658, 1047
BseLI	CCNNNNNNNGG	5 cut(s)	40, 220, 451, 565, 761
BseMI	GCAATG	2 cut(s)	600, 795
BseMII	CTCAG	1 cut(s)	1000
BseNI	ACTGG	3 cut(s)	290, 510, 713
BseX3I	CGGCCG	1 cut(s)	211
BseXI	GCAGC	4 cut(s)	264, 502, 567, 885
BseYI	CCCAGC	2 cut(s)	392, 992
BsgI	GTGCAG	1 cut(s)	474
Bsh1236I	CGCG	3 cut(s)	162, 216, 615
Bsh1285I	CGRYCG	1 cut(s)	214
BshFI	GGCC	4 cut(s)	50, 213, 449, 1010
BshNI	GGYRCC	2 cut(s)	22, 875
BsiEI	CGRYCG	1 cut(s)	214
BsiHKCI	CYCGRG	2 cut(s)	6, 777
BsiSI	CCGG	3 cut(s)	26, 414, 445
BsiWI	CGTACG	1 cut(s)	494
BslFI	GGGAC	1 cut(s)	1009
BslI	CCNNNNNNNGG	5 cut(s)	40, 220, 451, 565, 761
BsmAI	GTCTC	5 cut(s)	3, 72, 435, 503, 727
BsmBI	CGTCTC	2 cut(s)	3, 72
BsmFI	GGGAC	1 cut(s)	1009
BsnI	GGCC	4 cut(s)	50, 213, 449, 1010
BsoBI	CYCGRG	2 cut(s)	6, 777
Bsp143I	GATC	3 cut(s)	163, 178, 286
Bsp68I	TCGCGA	1 cut(s)	162
BspACI	CCGC	3 cut(s)	41, 214, 559
BspANI	GGCC	4 cut(s)	50, 213, 449, 1010
BspCNI	CTCAG	1 cut(s)	999
BspFNI	CGCG	3 cut(s)	162, 216, 615
BspLI	GGNNCC	4 cut(s)	24, 33, 288, 877
BspPI	GGATC	3 cut(s)	173, 281, 294
BspQI	GCTCTTC	1 cut(s)	315
BspT107I	GGYRCC	2 cut(s)	22, 875
BsrDI	GCAATG	2 cut(s)	600, 795
BsrFI	RCCGGY	2 cut(s)	25, 413
BsrI	ACTGG	3 cut(s)	290, 510, 713
BssAI	RCCGGY	2 cut(s)	25, 413
BssECI	CCNNGG	1 cut(s)	450
BssMI	GATC	3 cut(s)	163, 178, 286
BssT1I	CCWWGG	1 cut(s)	450
Bst4CI	ACNGT	4 cut(s)	92, 109, 336, 805
Bst6I	CTCTTC	3 cut(s)	264, 315, 581
BstAPI	GCANNNNNTGC	1 cut(s)	797
BstBAI	YACGTR	2 cut(s)	494, 1059
BstC8I	GCNNGC	4 cut(s)	160, 613, 793, 1153
BstDEI	CTNAG	1 cut(s)	986
BstENI	CCTNNNNNAGG	1 cut(s)	759
BstF5I	GGATG	4 cut(s)	301, 637, 658, 1047
BstFNI	CGCG	3 cut(s)	162, 216, 615
BstKTI	GATC	3 cut(s)	166, 181, 289
BstMAI	GTCTC	5 cut(s)	3, 72, 435, 503, 727
BstMBI	GATC	3 cut(s)	163, 178, 286
BstMCI	CGRYCG	1 cut(s)	214
BstMWI	GCNNNNNNNGC	8 cut(s)	47, 168, 467, 524, 643, 788, 797, 970
BstNSI	RCATGY	1 cut(s)	1084
BstSCI	CCNGG	1 cut(s)	444
BstSFI	CTRYAG	2 cut(s)	105, 225
BstUI	CGCG	3 cut(s)	162, 216, 615
BstV1I	GCAGC	4 cut(s)	264, 502, 567, 885
BstX2I	RGATCY	1 cut(s)	286
BstXI	CCANNNNNNTGG	1 cut(s)	374
BstYI	RGATCY	1 cut(s)	286
BstZI	CGGCCG	1 cut(s)	211
BsuI	GTATCC	2 cut(s)	753, 1070
BsuRI	GGCC	4 cut(s)	50, 213, 449, 1010
BtrI	CACGTC	1 cut(s)	118
BtsCI	GGATG	4 cut(s)	301, 637, 658, 1047
BtsI	GCAGTG	1 cut(s)	261
BtsIMutI	CAGTG	4 cut(s)	261, 297, 801, 994
BtuMI	TCGCGA	1 cut(s)	162
Cac8I	GCNNGC	4 cut(s)	160, 613, 793, 1153
Cfr10I	RCCGGY	2 cut(s)	25, 413
Cfr13I	GGNCC	3 cut(s)	31, 447, 728
Csp6I	GTAC	3 cut(s)	93, 495, 617
CviAII	CATG	5 cut(s)	136, 359, 1042, 1081, 1141
CviQI	GTAC	3 cut(s)	93, 495, 617
DdeI	CTNAG	1 cut(s)	986
DpnI	GATC	3 cut(s)	165, 180, 288
DpnII	GATC	3 cut(s)	163, 178, 286
EaeI	YGGCCR	3 cut(s)	48, 211, 1008
EagI	CGGCCG	1 cut(s)	211
Eam1104I	CTCTTC	3 cut(s)	264, 315, 581
EarI	CTCTTC	3 cut(s)	264, 315, 581
EclXI	CGGCCG	1 cut(s)	211
Eco130I	CCWWGG	1 cut(s)	450
Eco47I	GGWCC	2 cut(s)	31, 728
Eco52I	CGGCCG	1 cut(s)	211
Eco88I	CYCGRG	2 cut(s)	6, 777
EcoNI	CCTNNNNNAGG	1 cut(s)	759
EcoT14I	CCWWGG	1 cut(s)	450
ErhI	CCWWGG	1 cut(s)	450
Esp3I	CGTCTC	2 cut(s)	3, 72
FaeI	CATG	5 cut(s)	139, 362, 1045, 1084, 1144
FaqI	GGGAC	1 cut(s)	1009
FatI	CATG	5 cut(s)	135, 358, 1041, 1080, 1140
FauNDI	CATATG	1 cut(s)	1147
Fnu4HI	GCNGC	6 cut(s)	214, 278, 516, 556, 559, 899
FokI	GGATG	4 cut(s)	308, 644, 665, 1034
Fsp4HI	GCNGC	6 cut(s)	214, 278, 516, 556, 559, 899
GluI	GCNGC	6 cut(s)	214, 278, 516, 556, 559, 899
GsaI	CCCAGC	2 cut(s)	396, 996
GsuI	CTGGAG	1 cut(s)	527
HaeIII	GGCC	4 cut(s)	50, 213, 449, 1010
HapII	CCGG	3 cut(s)	26, 414, 445
Hin1II	CATG	5 cut(s)	139, 362, 1045, 1084, 1144
HincII	GTYRAC	1 cut(s)	606
HindII	GTYRAC	1 cut(s)	606
HinfI	GANTC	4 cut(s)	428, 958, 967, 997
HpaII	CCGG	3 cut(s)	26, 414, 445
HphI	GGTGA	2 cut(s)	428, 702
Hpy166II	GTNNAC	4 cut(s)	31, 121, 148, 606
Hpy188I	TCNGA	1 cut(s)	72
Hpy188III	TCNNGA	5 cut(s)	8, 161, 284, 687, 1176
Hpy8I	GTNNAC	4 cut(s)	31, 121, 148, 606
HpyAV	CCTTC	1 cut(s)	207
HpyCH4III	ACNGT	4 cut(s)	92, 109, 336, 805
HpyCH4IV	ACGT	4 cut(s)	117, 493, 825, 1058
HpyCH4V	TGCA	7 cut(s)	139, 477, 491, 593, 704, 865, 1098
HpyF10VI	GCNNNNNNNGC	8 cut(s)	47, 168, 467, 524, 643, 788, 797, 970
HpyF3I	CTNAG	1 cut(s)	986
HpySE526I	ACGT	4 cut(s)	117, 493, 825, 1058
Hsp92II	CATG	5 cut(s)	139, 362, 1045, 1084, 1144
Kzo9I	GATC	3 cut(s)	163, 178, 286
LguI	GCTCTTC	1 cut(s)	315
LmnI	GCTCC	1 cut(s)	241
Lsp1109I	GCAGC	4 cut(s)	264, 502, 567, 885
LweI	GCATC	2 cut(s)	400, 713
MaeII	ACGT	4 cut(s)	117, 493, 825, 1058
MaeIII	GTNAC	3 cut(s)	843, 1070, 1102
MalI	GATC	3 cut(s)	165, 180, 288
MboI	GATC	3 cut(s)	163, 178, 286
MboII	GAAGA	9 cut(s)	67, 70, 158, 281, 332, 431, 434, 598, 699
MfeI	CAATTG	1 cut(s)	736
MflI	RGATCY	1 cut(s)	286
MlsI	TGGCCA	1 cut(s)	1010
MluCI	AATT	9 cut(s)	235, 399, 471, 562, 581, 736, 887, 1032, 1134
MluNI	TGGCCA	1 cut(s)	1010
MlyI	GAGTC	2 cut(s)	437, 991
MmeI	TCCRAC	1 cut(s)	630
MnlI	CCTC	9 cut(s)	265, 351, 448, 553, 741, 760, 823, 844, 916
Mox20I	TGGCCA	1 cut(s)	1010
MroXI	GAANNNNTTC	2 cut(s)	324, 383
MscI	TGGCCA	1 cut(s)	1010
MseI	TTAA	1 cut(s)	249
Msp20I	TGGCCA	1 cut(s)	1010
MspA1I	CMGCKG	2 cut(s)	646, 964
MspI	CCGG	3 cut(s)	26, 414, 445
MspR9I	CCNGG	1 cut(s)	446
MunI	CAATTG	1 cut(s)	736
MvnI	CGCG	3 cut(s)	162, 216, 615
MwoI	GCNNNNNNNGC	8 cut(s)	47, 168, 467, 524, 643, 788, 797, 970
NciI	CCSGG	1 cut(s)	446
NdeI	CATATG	1 cut(s)	1147
NdeII	GATC	3 cut(s)	163, 178, 286
NlaIII	CATG	5 cut(s)	139, 362, 1045, 1084, 1144
NlaIV	GGNNCC	4 cut(s)	24, 33, 288, 877
NmeAIII	GCCGAG	1 cut(s)	189
NmuCI	GTSAC	1 cut(s)	1102
NruI	TCGCGA	1 cut(s)	162
NspI	RCATGY	1 cut(s)	1084
PaeR7I	CTCGAG	1 cut(s)	6
PciI	ACATGT	1 cut(s)	1080
PciSI	GCTCTTC	1 cut(s)	315
PdmI	GAANNNNTTC	2 cut(s)	324, 383
PfeI	GAWTC	2 cut(s)	958, 967
Pfl23II	CGTACG	1 cut(s)	494
PkrI	GCNGC	6 cut(s)	215, 279, 517, 557, 560, 900
PleI	GAGTC	2 cut(s)	436, 991
PpsI	GAGTC	2 cut(s)	436, 991
Ppu21I	YACGTR	2 cut(s)	494, 1059
PscI	ACATGT	1 cut(s)	1080
PspFI	CCCAGC	2 cut(s)	392, 992
PspLI	CGTACG	1 cut(s)	494
PspN4I	GGNNCC	4 cut(s)	24, 33, 288, 877
PspPI	GGNCC	3 cut(s)	31, 447, 728
PsuI	RGATCY	1 cut(s)	286
PvuII	CAGCTG	2 cut(s)	646, 964
RruI	TCGCGA	1 cut(s)	162
RsaI	GTAC	3 cut(s)	94, 496, 618
RsaNI	GTAC	3 cut(s)	93, 495, 617
SapI	GCTCTTC	1 cut(s)	315
SaqAI	TTAA	1 cut(s)	249
SatI	GCNGC	6 cut(s)	214, 278, 516, 556, 559, 899
Sau3AI	GATC	3 cut(s)	163, 178, 286
Sau96I	GGNCC	3 cut(s)	31, 447, 728
SchI	GAGTC	2 cut(s)	437, 991
ScrFI	CCNGG	1 cut(s)	446
SfaNI	GCATC	2 cut(s)	400, 713
SfcI	CTRYAG	2 cut(s)	105, 225
Sfr274I	CTCGAG	1 cut(s)	6
SinI	GGWCC	2 cut(s)	31, 728
SlaI	CTCGAG	1 cut(s)	6
SmlI	CTYRAG	3 cut(s)	6, 848, 974
SmoI	CTYRAG	3 cut(s)	6, 848, 974
Sse9I	AATT	9 cut(s)	235, 399, 471, 562, 581, 736, 887, 1032, 1134
SsiI	CCGC	3 cut(s)	41, 214, 559
SspI	AATATT	1 cut(s)	937
StyD4I	CCNGG	1 cut(s)	444
StyI	CCWWGG	1 cut(s)	450
TaaI	ACNGT	4 cut(s)	92, 109, 336, 805
TaiI	ACGT	4 cut(s)	120, 496, 828, 1061
TaqI	TCGA	2 cut(s)	7, 177
TasI	AATT	9 cut(s)	235, 399, 471, 562, 581, 736, 887, 1032, 1134
TauI	GCSGC	2 cut(s)	216, 561
TfiI	GAWTC	2 cut(s)	958, 967
Tru1I	TTAA	1 cut(s)	249
Tru9I	TTAA	1 cut(s)	249
TscAI	CASTG	4 cut(s)	268, 297, 808, 994
TseFI	GTSAC	1 cut(s)	1102
TseI	GCWGC	4 cut(s)	277, 515, 555, 898
Tsp45I	GTSAC	1 cut(s)	1102
TspDTI	ATGAA	5 cut(s)	312, 375, 1008, 1058, 1120
TspGWI	ACGGA	1 cut(s)	1089
TspRI	CASTG	4 cut(s)	268, 297, 808, 994
VpaK11BI	GGWCC	2 cut(s)	31, 728
XagI	CCTNNNNNAGG	1 cut(s)	759
XapI	RAATTY	1 cut(s)	1032
XceI	RCATGY	1 cut(s)	1084
XcmI	CCANNNNNNNNNTGG	1 cut(s)	1018
XhoI	CTCGAG	1 cut(s)	6
XmnI	GAANNNNTTC	2 cut(s)	324, 383

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.