Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| IMPDH | PF00478 | 64 - 186 | 2e-34 | IMP dehydrogenase / GMP reductase domain |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AasI | GACNNNNNNGTC | 2 cut(s) | 38, 170 |
| Acc65I | GGTACC | 1 cut(s) | 213 |
| AccB1I | GGYRCC | 1 cut(s) | 213 |
| AccBSI | CCGCTC | 1 cut(s) | 202 |
| AciI | CCGC | 5 cut(s) | 29, 125, 202, 269, 543 |
| AclWI | GGATC | 1 cut(s) | 212 |
| AcsI | RAATTY | 1 cut(s) | 460 |
| AfaI | GTAC | 4 cut(s) | 215, 392, 407, 520 |
| AfiI | CCNNNNNNNGG | 5 cut(s) | 16, 102, 142, 223, 224 |
| AhdI | GACNNNNNGTC | 1 cut(s) | 447 |
| AjiI | CACGTC | 2 cut(s) | 142, 196 |
| AluBI | AGCT | 4 cut(s) | 25, 66, 93, 351 |
| AluI | AGCT | 4 cut(s) | 25, 66, 93, 351 |
| Alw21I | GWGCWC | 1 cut(s) | 95 |
| AlwI | GGATC | 1 cut(s) | 212 |
| AoxI | GGCC | 2 cut(s) | 133, 242 |
| ApaI | GGGCCC | 1 cut(s) | 246 |
| ApeKI | GCWGC | 1 cut(s) | 146 |
| ApoI | RAATTY | 1 cut(s) | 460 |
| Asp718I | GGTACC | 1 cut(s) | 213 |
| AspLEI | GCGC | 1 cut(s) | 457 |
| AspS9I | GGNCC | 3 cut(s) | 242, 243, 504 |
| AsuHPI | GGTGA | 3 cut(s) | 31, 166, 328 |
| AsuNHI | GCTAGC | 1 cut(s) | 25 |
| AvaII | GGWCC | 1 cut(s) | 504 |
| BaeGI | GKGCMC | 1 cut(s) | 246 |
| BanI | GGYRCC | 1 cut(s) | 213 |
| BanII | GRGCYC | 2 cut(s) | 95, 246 |
| Bbv12I | GWGCWC | 1 cut(s) | 95 |
| BbvI | GCAGC | 1 cut(s) | 158 |
| BccI | CCATC | 2 cut(s) | 476, 493 |
| BceAI | ACGGC | 1 cut(s) | 120 |
| BclI | TGATCA | 2 cut(s) | 60, 384 |
| BfaI | CTAG | 1 cut(s) | 26 |
| BisI | GCNGC | 3 cut(s) | 147, 270, 544 |
| BlsI | GCNGC | 3 cut(s) | 148, 271, 545 |
| Bme18I | GGWCC | 1 cut(s) | 504 |
| BmeRI | GACNNNNNGTC | 1 cut(s) | 447 |
| BmgBI | CACGTC | 2 cut(s) | 142, 196 |
| BmgT120I | GGNCC | 3 cut(s) | 242, 243, 504 |
| BmiI | GGNNCC | 4 cut(s) | 215, 244, 505, 511 |
| BmtI | GCTAGC | 1 cut(s) | 29 |
| BpuEI | CTTGAG | 1 cut(s) | 510 |
| BsaJI | CCNNGG | 1 cut(s) | 86 |
| Bsc4I | CCNNNNNNNGG | 5 cut(s) | 16, 102, 142, 223, 224 |
| BseDI | CCNNGG | 1 cut(s) | 86 |
| BseGI | GGATG | 3 cut(s) | 285, 424, 504 |
| BseLI | CCNNNNNNNGG | 5 cut(s) | 16, 102, 142, 223, 224 |
| BseMII | CTCAG | 1 cut(s) | 423 |
| BseRI | GAGGAG | 2 cut(s) | 128, 323 |
| BseSI | GKGCMC | 1 cut(s) | 246 |
| BseXI | GCAGC | 1 cut(s) | 158 |
| BseYI | CCCAGC | 1 cut(s) | 323 |
| BshFI | GGCC | 2 cut(s) | 135, 244 |
| BshNI | GGYRCC | 1 cut(s) | 213 |
| BsiHKAI | GWGCWC | 1 cut(s) | 95 |
| BsiSI | CCGG | 1 cut(s) | 507 |
| BslFI | GGGAC | 1 cut(s) | 173 |
| BslI | CCNNNNNNNGG | 5 cut(s) | 16, 102, 142, 223, 224 |
| BsmFI | GGGAC | 1 cut(s) | 173 |
| BsnI | GGCC | 2 cut(s) | 135, 244 |
| Bsp120I | GGGCCC | 1 cut(s) | 242 |
| Bsp1286I | GDGCHC | 2 cut(s) | 95, 246 |
| Bsp143I | GATC | 3 cut(s) | 60, 204, 384 |
| BspACI | CCGC | 5 cut(s) | 29, 125, 202, 269, 543 |
| BspANI | GGCC | 2 cut(s) | 135, 244 |
| BspCNI | CTCAG | 1 cut(s) | 422 |
| BspLI | GGNNCC | 4 cut(s) | 215, 244, 505, 511 |
| BspOI | GCTAGC | 1 cut(s) | 29 |
| BspPI | GGATC | 1 cut(s) | 212 |
| BspT107I | GGYRCC | 1 cut(s) | 213 |
| BsrBI | CCGCTC | 1 cut(s) | 202 |
| BssECI | CCNNGG | 1 cut(s) | 86 |
| BssMI | GATC | 3 cut(s) | 60, 204, 384 |
| BssT1I | CCWWGG | 1 cut(s) | 86 |
| Bst4CI | ACNGT | 2 cut(s) | 154, 445 |
| BstC8I | GCNNGC | 2 cut(s) | 7, 27 |
| BstDEI | CTNAG | 1 cut(s) | 409 |
| BstF5I | GGATG | 3 cut(s) | 285, 424, 504 |
| BstHHI | GCGC | 1 cut(s) | 457 |
| BstKTI | GATC | 3 cut(s) | 63, 207, 387 |
| BstMBI | GATC | 3 cut(s) | 60, 204, 384 |
| BstMWI | GCNNNNNNNGC | 1 cut(s) | 543 |
| BstSLI | GKGCMC | 1 cut(s) | 246 |
| BstV1I | GCAGC | 1 cut(s) | 158 |
| BsuRI | GGCC | 2 cut(s) | 135, 244 |
| BtrI | CACGTC | 2 cut(s) | 142, 196 |
| BtsCI | GGATG | 3 cut(s) | 285, 424, 504 |
| Cac8I | GCNNGC | 2 cut(s) | 7, 27 |
| CfoI | GCGC | 1 cut(s) | 457 |
| Cfr13I | GGNCC | 3 cut(s) | 242, 243, 504 |
| CseI | GACGC | 1 cut(s) | 526 |
| Csp6I | GTAC | 4 cut(s) | 214, 391, 406, 519 |
| CviAII | CATG | 3 cut(s) | 58, 76, 121 |
| CviQI | GTAC | 4 cut(s) | 214, 391, 406, 519 |
| DdeI | CTNAG | 1 cut(s) | 409 |
| DpnI | GATC | 3 cut(s) | 62, 206, 386 |
| DpnII | GATC | 3 cut(s) | 60, 204, 384 |
| DrdI | GACNNNNNNGTC | 2 cut(s) | 38, 170 |
| DriI | GACNNNNNGTC | 1 cut(s) | 447 |
| DseDI | GACNNNNNNGTC | 2 cut(s) | 38, 170 |
| Eam1105I | GACNNNNNGTC | 1 cut(s) | 447 |
| EciI | GGCGGA | 1 cut(s) | 140 |
| Ecl136II | GAGCTC | 1 cut(s) | 93 |
| Eco130I | CCWWGG | 1 cut(s) | 86 |
| Eco24I | GRGCYC | 2 cut(s) | 95, 246 |
| Eco47I | GGWCC | 1 cut(s) | 504 |
| Eco53kI | GAGCTC | 1 cut(s) | 93 |
| EcoICRI | GAGCTC | 1 cut(s) | 93 |
| EcoT14I | CCWWGG | 1 cut(s) | 86 |
| EcoT38I | GRGCYC | 2 cut(s) | 95, 246 |
| ErhI | CCWWGG | 1 cut(s) | 86 |
| FaeI | CATG | 3 cut(s) | 61, 79, 124 |
| FaiI | YATR | 4 cut(s) | 59, 77, 122, 559 |
| FaqI | GGGAC | 1 cut(s) | 173 |
| FatI | CATG | 3 cut(s) | 57, 75, 120 |
| FbaI | TGATCA | 2 cut(s) | 60, 384 |
| Fnu4HI | GCNGC | 3 cut(s) | 147, 270, 544 |
| FokI | GGATG | 3 cut(s) | 292, 431, 511 |
| FriOI | GRGCYC | 2 cut(s) | 95, 246 |
| Fsp4HI | GCNGC | 3 cut(s) | 147, 270, 544 |
| FspBI | CTAG | 1 cut(s) | 26 |
| GlaI | GCGC | 1 cut(s) | 456 |
| GluI | GCNGC | 3 cut(s) | 147, 270, 544 |
| GsaI | CCCAGC | 1 cut(s) | 327 |
| HaeIII | GGCC | 2 cut(s) | 135, 244 |
| HapII | CCGG | 1 cut(s) | 507 |
| HgaI | GACGC | 1 cut(s) | 526 |
| HhaI | GCGC | 1 cut(s) | 457 |
| Hin1II | CATG | 3 cut(s) | 61, 79, 124 |
| Hin6I | GCGC | 1 cut(s) | 455 |
| HinP1I | GCGC | 1 cut(s) | 455 |
| HincII | GTYRAC | 1 cut(s) | 441 |
| HindII | GTYRAC | 1 cut(s) | 441 |
| HinfI | GANTC | 3 cut(s) | 287, 448, 466 |
| HpaII | CCGG | 1 cut(s) | 507 |
| HphI | GGTGA | 3 cut(s) | 31, 166, 328 |
| Hpy166II | GTNNAC | 1 cut(s) | 441 |
| Hpy188I | TCNGA | 4 cut(s) | 97, 292, 375, 412 |
| Hpy188III | TCNNGA | 3 cut(s) | 43, 397, 527 |
| Hpy8I | GTNNAC | 1 cut(s) | 441 |
| Hpy99I | CGWCG | 3 cut(s) | 167, 251, 542 |
| HpyAV | CCTTC | 3 cut(s) | 181, 253, 313 |
| HpyCH4III | ACNGT | 2 cut(s) | 154, 445 |
| HpyCH4IV | ACGT | 2 cut(s) | 141, 195 |
| HpyF10VI | GCNNNNNNNGC | 1 cut(s) | 543 |
| HpyF3I | CTNAG | 1 cut(s) | 409 |
| HpySE526I | ACGT | 2 cut(s) | 141, 195 |
| Hsp92II | CATG | 3 cut(s) | 61, 79, 124 |
| HspAI | GCGC | 1 cut(s) | 455 |
| KpnI | GGTACC | 1 cut(s) | 217 |
| Ksp22I | TGATCA | 2 cut(s) | 60, 384 |
| Kzo9I | GATC | 3 cut(s) | 60, 204, 384 |
| LmnI | GCTCC | 4 cut(s) | 90, 98, 199, 515 |
| LpnPI | CCDG | 8 cut(s) | 309, 341, 437, 455, 459, 520, 532, 539 |
| Lsp1109I | GCAGC | 1 cut(s) | 158 |
| MaeI | CTAG | 1 cut(s) | 26 |
| MaeII | ACGT | 2 cut(s) | 141, 195 |
| MaeIII | GTNAC | 1 cut(s) | 137 |
| MalI | GATC | 3 cut(s) | 62, 206, 386 |
| MbiI | CCGCTC | 1 cut(s) | 202 |
| MboI | GATC | 3 cut(s) | 60, 204, 384 |
| MboII | GAAGA | 1 cut(s) | 118 |
| MhlI | GDGCHC | 2 cut(s) | 95, 246 |
| MluCI | AATT | 1 cut(s) | 460 |
| MlyI | GAGTC | 2 cut(s) | 296, 457 |
| MmeI | TCCRAC | 2 cut(s) | 270, 324 |
| MnlI | CCTC | 9 cut(s) | 31, 106, 150, 160, 184, 276, 301, 483, 523 |
| MspA1I | CMGCKG | 1 cut(s) | 66 |
| MspI | CCGG | 1 cut(s) | 507 |
| MwoI | GCNNNNNNNGC | 1 cut(s) | 543 |
| NdeII | GATC | 3 cut(s) | 60, 204, 384 |
| NheI | GCTAGC | 1 cut(s) | 25 |
| NlaIII | CATG | 3 cut(s) | 61, 79, 124 |
| NlaIV | GGNNCC | 4 cut(s) | 215, 244, 505, 511 |
| NmuCI | GTSAC | 1 cut(s) | 137 |
| PcsI | WCGNNNNNNNCGW | 1 cut(s) | 171 |
| PfeI | GAWTC | 1 cut(s) | 466 |
| PkrI | GCNGC | 3 cut(s) | 148, 271, 545 |
| PleI | GAGTC | 2 cut(s) | 295, 456 |
| PpsI | GAGTC | 2 cut(s) | 295, 456 |
| Psp124BI | GAGCTC | 1 cut(s) | 95 |
| PspFI | CCCAGC | 1 cut(s) | 323 |
| PspN4I | GGNNCC | 4 cut(s) | 215, 244, 505, 511 |
| PspOMI | GGGCCC | 1 cut(s) | 242 |
| PspPI | GGNCC | 3 cut(s) | 242, 243, 504 |
| PvuII | CAGCTG | 1 cut(s) | 66 |
| RsaI | GTAC | 4 cut(s) | 215, 392, 407, 520 |
| RsaNI | GTAC | 4 cut(s) | 214, 391, 406, 519 |
| SacI | GAGCTC | 1 cut(s) | 95 |
| SatI | GCNGC | 3 cut(s) | 147, 270, 544 |
| Sau3AI | GATC | 3 cut(s) | 60, 204, 384 |
| Sau96I | GGNCC | 3 cut(s) | 242, 243, 504 |
| SchI | GAGTC | 2 cut(s) | 296, 457 |
| SduI | GDGCHC | 2 cut(s) | 95, 246 |
| SinI | GGWCC | 1 cut(s) | 504 |
| SmlI | CTYRAG | 1 cut(s) | 525 |
| SmoI | CTYRAG | 1 cut(s) | 525 |
| Sse9I | AATT | 1 cut(s) | 460 |
| SsiI | CCGC | 5 cut(s) | 29, 125, 202, 269, 543 |
| SspMI | CTAG | 1 cut(s) | 26 |
| SstI | GAGCTC | 1 cut(s) | 95 |
| StyI | CCWWGG | 1 cut(s) | 86 |
| TaaI | ACNGT | 2 cut(s) | 154, 445 |
| TaiI | ACGT | 2 cut(s) | 144, 198 |
| TaqI | TCGA | 1 cut(s) | 174 |
| TasI | AATT | 1 cut(s) | 460 |
| TatI | WGTACW | 3 cut(s) | 390, 405, 518 |
| TauI | GCSGC | 2 cut(s) | 272, 546 |
| TfiI | GAWTC | 1 cut(s) | 466 |
| TseFI | GTSAC | 1 cut(s) | 137 |
| TseI | GCWGC | 1 cut(s) | 146 |
| Tsp45I | GTSAC | 1 cut(s) | 137 |
| TspDTI | ATGAA | 1 cut(s) | 109 |
| VpaK11BI | GGWCC | 1 cut(s) | 504 |
| XapI | RAATTY | 1 cut(s) | 460 |
| XspI | CTAG | 1 cut(s) | 26 |