Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| IMPDH | PF00478 | 1 - 125 | 9e-25 | IMP dehydrogenase / GMP reductase domain |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AasI | GACNNNNNNGTC | 1 cut(s) | 81 |
| AcuI | CTGAAG | 1 cut(s) | 194 |
| AfaI | GTAC | 3 cut(s) | 28, 234, 239 |
| AfiI | CCNNNNNNNGG | 1 cut(s) | 109 |
| AflII | CTTAAG | 1 cut(s) | 310 |
| AgsI | TTSAA | 1 cut(s) | 122 |
| AjnI | CCWGG | 2 cut(s) | 37, 316 |
| AluBI | AGCT | 4 cut(s) | 12, 20, 172, 350 |
| AluI | AGCT | 4 cut(s) | 12, 20, 172, 350 |
| Alw26I | GTCTC | 1 cut(s) | 62 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 350 |
| AoxI | GGCC | 1 cut(s) | 33 |
| ApeKI | GCWGC | 1 cut(s) | 350 |
| AspLEI | GCGC | 1 cut(s) | 281 |
| AspS9I | GGNCC | 1 cut(s) | 34 |
| BanII | GRGCYC | 1 cut(s) | 116 |
| BbvI | GCAGC | 1 cut(s) | 337 |
| BciT130I | CCWGG | 2 cut(s) | 39, 318 |
| BclI | TGATCA | 1 cut(s) | 142 |
| BcoDI | GTCTC | 1 cut(s) | 62 |
| BfaI | CTAG | 1 cut(s) | 332 |
| BfmI | CTRYAG | 1 cut(s) | 290 |
| BfoI | RGCGCY | 1 cut(s) | 282 |
| BfrI | CTTAAG | 1 cut(s) | 310 |
| BglI | GCCNNNNNGGC | 1 cut(s) | 41 |
| BglII | AGATCT | 1 cut(s) | 271 |
| BisI | GCNGC | 1 cut(s) | 351 |
| BlsI | GCNGC | 1 cut(s) | 352 |
| BmcAI | AGTACT | 1 cut(s) | 28 |
| Bme1390I | CCNGG | 2 cut(s) | 39, 318 |
| BmgT120I | GGNCC | 1 cut(s) | 34 |
| BmiI | GGNNCC | 1 cut(s) | 36 |
| BmrFI | CCNGG | 2 cut(s) | 39, 318 |
| BpuEI | CTTGAG | 1 cut(s) | 339 |
| BsaJI | CCNNGG | 4 cut(s) | 37, 38, 103, 317 |
| Bsc4I | CCNNNNNNNGG | 1 cut(s) | 109 |
| BseBI | CCWGG | 2 cut(s) | 39, 318 |
| BseDI | CCNNGG | 4 cut(s) | 37, 38, 103, 317 |
| BseLI | CCNNNNNNNGG | 1 cut(s) | 109 |
| BseMII | CTCAG | 2 cut(s) | 21, 57 |
| BseXI | GCAGC | 1 cut(s) | 337 |
| BsgI | GTGCAG | 1 cut(s) | 219 |
| BshFI | GGCC | 1 cut(s) | 35 |
| BsiSI | CCGG | 1 cut(s) | 88 |
| BslI | CCNNNNNNNGG | 1 cut(s) | 109 |
| BsmAI | GTCTC | 1 cut(s) | 62 |
| BsnI | GGCC | 1 cut(s) | 35 |
| Bsp1286I | GDGCHC | 1 cut(s) | 116 |
| Bsp143I | GATC | 2 cut(s) | 142, 271 |
| BspANI | GGCC | 1 cut(s) | 35 |
| BspCNI | CTCAG | 2 cut(s) | 22, 58 |
| BspHI | TCATGA | 1 cut(s) | 301 |
| BspLI | GGNNCC | 1 cut(s) | 36 |
| BspMAI | CTGCAG | 1 cut(s) | 294 |
| BspTI | CTTAAG | 1 cut(s) | 310 |
| BssECI | CCNNGG | 4 cut(s) | 37, 38, 103, 317 |
| BssMI | GATC | 2 cut(s) | 142, 271 |
| Bst2UI | CCWGG | 2 cut(s) | 39, 318 |
| Bst4CI | ACNGT | 1 cut(s) | 237 |
| BstAFI | CTTAAG | 1 cut(s) | 310 |
| BstC8I | GCNNGC | 1 cut(s) | 249 |
| BstDEI | CTNAG | 3 cut(s) | 16, 30, 66 |
| BstH2I | RGCGCY | 1 cut(s) | 282 |
| BstHHI | GCGC | 1 cut(s) | 281 |
| BstKTI | GATC | 2 cut(s) | 145, 274 |
| BstMAI | GTCTC | 1 cut(s) | 62 |
| BstMBI | GATC | 2 cut(s) | 142, 271 |
| BstMWI | GCNNNNNNNGC | 1 cut(s) | 41 |
| BstNI | CCWGG | 2 cut(s) | 39, 318 |
| BstSCI | CCNGG | 2 cut(s) | 37, 316 |
| BstSFI | CTRYAG | 1 cut(s) | 290 |
| BstV1I | GCAGC | 1 cut(s) | 337 |
| BstX2I | RGATCY | 1 cut(s) | 271 |
| BstYI | RGATCY | 1 cut(s) | 271 |
| BsuRI | GGCC | 1 cut(s) | 35 |
| BtgZI | GCGATG | 1 cut(s) | 140 |
| BtsI | GCAGTG | 1 cut(s) | 258 |
| BtsIMutI | CAGTG | 1 cut(s) | 258 |
| Cac8I | GCNNGC | 1 cut(s) | 249 |
| CaiI | CAGNNNCTG | 1 cut(s) | 350 |
| CciI | TCATGA | 1 cut(s) | 301 |
| CfoI | GCGC | 1 cut(s) | 281 |
| Cfr13I | GGNCC | 1 cut(s) | 34 |
| Csp6I | GTAC | 3 cut(s) | 27, 233, 238 |
| CviAII | CATG | 3 cut(s) | 109, 302, 374 |
| CviJI | RGCY | 8 cut(s) | 12, 20, 35, 44, 114, 172, 331, 350 |
| CviKI_1 | RGCY | 8 cut(s) | 12, 20, 35, 44, 114, 172, 331, 350 |
| CviQI | GTAC | 3 cut(s) | 27, 233, 238 |
| DdeI | CTNAG | 3 cut(s) | 16, 30, 66 |
| DpnI | GATC | 2 cut(s) | 144, 273 |
| DpnII | GATC | 2 cut(s) | 142, 271 |
| DraI | TTTAAA | 1 cut(s) | 225 |
| DrdI | GACNNNNNNGTC | 1 cut(s) | 81 |
| DseDI | GACNNNNNNGTC | 1 cut(s) | 81 |
| Eco24I | GRGCYC | 1 cut(s) | 116 |
| Eco57I | CTGAAG | 1 cut(s) | 194 |
| EcoO109I | RGGNCCY | 1 cut(s) | 34 |
| EcoRII | CCWGG | 2 cut(s) | 37, 316 |
| EcoT38I | GRGCYC | 1 cut(s) | 116 |
| FaeI | CATG | 3 cut(s) | 112, 305, 377 |
| FaiI | YATR | 4 cut(s) | 48, 110, 303, 375 |
| FatI | CATG | 3 cut(s) | 108, 301, 373 |
| FbaI | TGATCA | 1 cut(s) | 142 |
| Fnu4HI | GCNGC | 1 cut(s) | 351 |
| FriOI | GRGCYC | 1 cut(s) | 116 |
| Fsp4HI | GCNGC | 1 cut(s) | 351 |
| FspBI | CTAG | 1 cut(s) | 332 |
| GlaI | GCGC | 1 cut(s) | 280 |
| GluI | GCNGC | 1 cut(s) | 351 |
| HaeII | RGCGCY | 1 cut(s) | 282 |
| HaeIII | GGCC | 1 cut(s) | 35 |
| HapII | CCGG | 1 cut(s) | 88 |
| HhaI | GCGC | 1 cut(s) | 281 |
| Hin1II | CATG | 3 cut(s) | 112, 305, 377 |
| Hin6I | GCGC | 1 cut(s) | 279 |
| HinP1I | GCGC | 1 cut(s) | 279 |
| HinfI | GANTC | 1 cut(s) | 52 |
| HpaII | CCGG | 1 cut(s) | 88 |
| Hpy166II | GTNNAC | 1 cut(s) | 240 |
| Hpy188III | TCNNGA | 2 cut(s) | 119, 302 |
| Hpy8I | GTNNAC | 1 cut(s) | 240 |
| HpyAV | CCTTC | 1 cut(s) | 356 |
| HpyCH4III | ACNGT | 1 cut(s) | 237 |
| HpyCH4V | TGCA | 5 cut(s) | 182, 200, 206, 247, 292 |
| HpyF10VI | GCNNNNNNNGC | 1 cut(s) | 41 |
| HpyF3I | CTNAG | 3 cut(s) | 16, 30, 66 |
| Hsp92II | CATG | 3 cut(s) | 112, 305, 377 |
| HspAI | GCGC | 1 cut(s) | 279 |
| Ksp22I | TGATCA | 1 cut(s) | 142 |
| Kzo9I | GATC | 2 cut(s) | 142, 271 |
| LmnI | GCTCC | 2 cut(s) | 9, 347 |
| Lsp1109I | GCAGC | 1 cut(s) | 337 |
| MaeI | CTAG | 1 cut(s) | 332 |
| MalI | GATC | 2 cut(s) | 144, 273 |
| MboI | GATC | 2 cut(s) | 142, 271 |
| MboII | GAAGA | 3 cut(s) | 187, 276, 406 |
| MflI | RGATCY | 1 cut(s) | 271 |
| MhlI | GDGCHC | 1 cut(s) | 116 |
| MnlI | CCTC | 4 cut(s) | 25, 98, 317, 328 |
| MseI | TTAA | 3 cut(s) | 224, 311, 326 |
| MspCI | CTTAAG | 1 cut(s) | 310 |
| MspI | CCGG | 1 cut(s) | 88 |
| MspR9I | CCNGG | 2 cut(s) | 39, 318 |
| MvaI | CCWGG | 2 cut(s) | 39, 318 |
| MwoI | GCNNNNNNNGC | 1 cut(s) | 41 |
| NdeII | GATC | 2 cut(s) | 142, 271 |
| NlaIII | CATG | 3 cut(s) | 112, 305, 377 |
| NlaIV | GGNNCC | 1 cut(s) | 36 |
| NmeAIII | GCCGAG | 1 cut(s) | 255 |
| PagI | TCATGA | 1 cut(s) | 301 |
| PasI | CCCWGGG | 1 cut(s) | 38 |
| PfeI | GAWTC | 1 cut(s) | 52 |
| PkrI | GCNGC | 1 cut(s) | 352 |
| Psp6I | CCWGG | 2 cut(s) | 37, 316 |
| PspGI | CCWGG | 2 cut(s) | 37, 316 |
| PspN4I | GGNNCC | 1 cut(s) | 36 |
| PspPI | GGNCC | 1 cut(s) | 34 |
| PstI | CTGCAG | 1 cut(s) | 294 |
| PstNI | CAGNNNCTG | 1 cut(s) | 350 |
| PsuI | RGATCY | 1 cut(s) | 271 |
| RsaI | GTAC | 3 cut(s) | 28, 234, 239 |
| RsaNI | GTAC | 3 cut(s) | 27, 233, 238 |
| SaqAI | TTAA | 3 cut(s) | 224, 311, 326 |
| SatI | GCNGC | 1 cut(s) | 351 |
| Sau3AI | GATC | 2 cut(s) | 142, 271 |
| Sau96I | GGNCC | 1 cut(s) | 34 |
| ScaI | AGTACT | 1 cut(s) | 28 |
| ScrFI | CCNGG | 2 cut(s) | 39, 318 |
| SduI | GDGCHC | 1 cut(s) | 116 |
| SfcI | CTRYAG | 1 cut(s) | 290 |
| SmlI | CTYRAG | 2 cut(s) | 310, 354 |
| SmoI | CTYRAG | 2 cut(s) | 310, 354 |
| SspMI | CTAG | 1 cut(s) | 332 |
| StyD4I | CCNGG | 2 cut(s) | 37, 316 |
| TaaI | ACNGT | 1 cut(s) | 237 |
| TatI | WGTACW | 1 cut(s) | 26 |
| TfiI | GAWTC | 1 cut(s) | 52 |
| Tru1I | TTAA | 3 cut(s) | 224, 311, 326 |
| Tru9I | TTAA | 3 cut(s) | 224, 311, 326 |
| TscAI | CASTG | 1 cut(s) | 258 |
| TseI | GCWGC | 1 cut(s) | 350 |
| TspDTI | ATGAA | 1 cut(s) | 362 |
| TspRI | CASTG | 1 cut(s) | 258 |
| Vha464I | CTTAAG | 1 cut(s) | 310 |
| XspI | CTAG | 1 cut(s) | 332 |
| ZrmI | AGTACT | 1 cut(s) | 28 |