Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AciI | CCGC | 1 cut(s) | 161 |
| AcsI | RAATTY | 2 cut(s) | 58, 222 |
| AdeI | CACNNNGTG | 1 cut(s) | 194 |
| AfaI | GTAC | 2 cut(s) | 5, 118 |
| AfiI | CCNNNNNNNGG | 1 cut(s) | 144 |
| AgsI | TTSAA | 1 cut(s) | 88 |
| AhdI | GACNNNNNGTC | 2 cut(s) | 45, 242 |
| AhlI | ACTAGT | 1 cut(s) | 119 |
| AjnI | CCWGG | 1 cut(s) | 313 |
| AluBI | AGCT | 2 cut(s) | 288, 296 |
| AluI | AGCT | 2 cut(s) | 288, 296 |
| ApoI | RAATTY | 2 cut(s) | 58, 222 |
| AspLEI | GCGC | 1 cut(s) | 137 |
| AsuHPI | GGTGA | 1 cut(s) | 49 |
| BccI | CCATC | 4 cut(s) | 74, 91, 209, 274 |
| BceAI | ACGGC | 1 cut(s) | 122 |
| BciT130I | CCWGG | 1 cut(s) | 315 |
| BcuI | ACTAGT | 1 cut(s) | 119 |
| BfaI | CTAG | 1 cut(s) | 120 |
| Bme1390I | CCNGG | 1 cut(s) | 315 |
| BmeRI | GACNNNNNGTC | 2 cut(s) | 45, 242 |
| BmiI | GGNNCC | 2 cut(s) | 109, 312 |
| BmrFI | CCNGG | 1 cut(s) | 315 |
| BmsI | GCATC | 1 cut(s) | 185 |
| BsaJI | CCNNGG | 2 cut(s) | 259, 314 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 295, 325 |
| Bsc4I | CCNNNNNNNGG | 1 cut(s) | 144 |
| Bse3DI | GCAATG | 1 cut(s) | 207 |
| BseBI | CCWGG | 1 cut(s) | 315 |
| BseDI | CCNNGG | 2 cut(s) | 259, 314 |
| BseGI | GGATG | 2 cut(s) | 22, 102 |
| BseLI | CCNNNNNNNGG | 1 cut(s) | 144 |
| BseMI | GCAATG | 1 cut(s) | 207 |
| BseMII | CTCAG | 3 cut(s) | 21, 297, 333 |
| BslFI | GGGAC | 1 cut(s) | 162 |
| BslI | CCNNNNNNNGG | 1 cut(s) | 144 |
| BsmFI | GGGAC | 1 cut(s) | 162 |
| BspACI | CCGC | 1 cut(s) | 161 |
| BspCNI | CTCAG | 3 cut(s) | 20, 298, 334 |
| BspHI | TCATGA | 1 cut(s) | 276 |
| BspLI | GGNNCC | 2 cut(s) | 109, 312 |
| BsrDI | GCAATG | 1 cut(s) | 207 |
| BssECI | CCNNGG | 2 cut(s) | 259, 314 |
| BssT1I | CCWWGG | 1 cut(s) | 259 |
| Bst2UI | CCWGG | 1 cut(s) | 315 |
| Bst4CI | ACNGT | 2 cut(s) | 43, 274 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 182 |
| BstDEI | CTNAG | 4 cut(s) | 7, 292, 306, 342 |
| BstF5I | GGATG | 2 cut(s) | 22, 102 |
| BstHHI | GCGC | 1 cut(s) | 137 |
| BstMWI | GCNNNNNNNGC | 3 cut(s) | 141, 182, 317 |
| BstNI | CCWGG | 1 cut(s) | 315 |
| BstSCI | CCNGG | 1 cut(s) | 313 |
| BtsCI | GGATG | 2 cut(s) | 22, 102 |
| BtsIMutI | CAGTG | 1 cut(s) | 303 |
| CciI | TCATGA | 1 cut(s) | 276 |
| CfoI | GCGC | 1 cut(s) | 137 |
| Csp6I | GTAC | 2 cut(s) | 4, 117 |
| CviAII | CATG | 1 cut(s) | 277 |
| CviJI | RGCY | 8 cut(s) | 71, 108, 251, 266, 288, 296, 311, 320 |
| CviKI_1 | RGCY | 8 cut(s) | 71, 108, 251, 266, 288, 296, 311, 320 |
| CviQI | GTAC | 2 cut(s) | 4, 117 |
| DdeI | CTNAG | 4 cut(s) | 7, 292, 306, 342 |
| DraIII | CACNNNGTG | 1 cut(s) | 194 |
| DriI | GACNNNNNGTC | 2 cut(s) | 45, 242 |
| Eam1105I | GACNNNNNGTC | 2 cut(s) | 45, 242 |
| Eco130I | CCWWGG | 1 cut(s) | 259 |
| EcoRII | CCWGG | 1 cut(s) | 313 |
| EcoT14I | CCWWGG | 1 cut(s) | 259 |
| ErhI | CCWWGG | 1 cut(s) | 259 |
| FaeI | CATG | 1 cut(s) | 280 |
| FaiI | YATR | 3 cut(s) | 278, 324, 349 |
| FaqI | GGGAC | 1 cut(s) | 162 |
| FatI | CATG | 1 cut(s) | 276 |
| FokI | GGATG | 2 cut(s) | 29, 109 |
| FspBI | CTAG | 1 cut(s) | 120 |
| GlaI | GCGC | 1 cut(s) | 136 |
| HhaI | GCGC | 1 cut(s) | 137 |
| Hin1II | CATG | 1 cut(s) | 280 |
| Hin6I | GCGC | 1 cut(s) | 135 |
| HinP1I | GCGC | 1 cut(s) | 135 |
| HindIII | AAGCTT | 1 cut(s) | 286 |
| HinfI | GANTC | 2 cut(s) | 46, 64 |
| HphI | GGTGA | 1 cut(s) | 49 |
| Hpy166II | GTNNAC | 1 cut(s) | 166 |
| Hpy188I | TCNGA | 1 cut(s) | 10 |
| Hpy188III | TCNNGA | 3 cut(s) | 125, 234, 277 |
| Hpy8I | GTNNAC | 1 cut(s) | 166 |
| Hpy99I | CGWCG | 1 cut(s) | 143 |
| HpyAV | CCTTC | 1 cut(s) | 82 |
| HpyCH4III | ACNGT | 2 cut(s) | 43, 274 |
| HpyCH4V | TGCA | 1 cut(s) | 176 |
| HpyF10VI | GCNNNNNNNGC | 3 cut(s) | 141, 182, 317 |
| HpyF3I | CTNAG | 4 cut(s) | 7, 292, 306, 342 |
| Hsp92II | CATG | 1 cut(s) | 280 |
| HspAI | GCGC | 1 cut(s) | 135 |
| LmnI | GCTCC | 2 cut(s) | 113, 316 |
| LweI | GCATC | 1 cut(s) | 185 |
| MaeI | CTAG | 1 cut(s) | 120 |
| MaeIII | GTNAC | 1 cut(s) | 37 |
| MluCI | AATT | 3 cut(s) | 58, 222, 229 |
| MlyI | GAGTC | 1 cut(s) | 55 |
| MnlI | CCTC | 2 cut(s) | 121, 301 |
| MseI | TTAA | 1 cut(s) | 254 |
| MspR9I | CCNGG | 1 cut(s) | 315 |
| MvaI | CCWGG | 1 cut(s) | 315 |
| MwoI | GCNNNNNNNGC | 3 cut(s) | 141, 182, 317 |
| NlaIII | CATG | 1 cut(s) | 280 |
| NlaIV | GGNNCC | 2 cut(s) | 109, 312 |
| NmuCI | GTSAC | 1 cut(s) | 37 |
| PagI | TCATGA | 1 cut(s) | 276 |
| PfeI | GAWTC | 1 cut(s) | 64 |
| PleI | GAGTC | 1 cut(s) | 54 |
| PpsI | GAGTC | 1 cut(s) | 54 |
| Psp6I | CCWGG | 1 cut(s) | 313 |
| PspGI | CCWGG | 1 cut(s) | 313 |
| PspN4I | GGNNCC | 2 cut(s) | 109, 312 |
| RsaI | GTAC | 2 cut(s) | 5, 118 |
| RsaNI | GTAC | 2 cut(s) | 4, 117 |
| SaqAI | TTAA | 1 cut(s) | 254 |
| SchI | GAGTC | 1 cut(s) | 55 |
| ScrFI | CCNGG | 1 cut(s) | 315 |
| SetI | ASST | 6 cut(s) | 93, 132, 174, 290, 298, 336 |
| SfaNI | GCATC | 1 cut(s) | 185 |
| SpeI | ACTAGT | 1 cut(s) | 119 |
| Sse9I | AATT | 3 cut(s) | 58, 222, 229 |
| SsiI | CCGC | 1 cut(s) | 161 |
| SspMI | CTAG | 1 cut(s) | 120 |
| StyD4I | CCNGG | 1 cut(s) | 313 |
| StyI | CCWWGG | 1 cut(s) | 259 |
| TaaI | ACNGT | 2 cut(s) | 43, 274 |
| TasI | AATT | 3 cut(s) | 58, 222, 229 |
| TatI | WGTACW | 2 cut(s) | 3, 116 |
| TfiI | GAWTC | 1 cut(s) | 64 |
| Tru1I | TTAA | 1 cut(s) | 254 |
| Tru9I | TTAA | 1 cut(s) | 254 |
| TscAI | CASTG | 1 cut(s) | 310 |
| TseFI | GTSAC | 1 cut(s) | 37 |
| Tsp45I | GTSAC | 1 cut(s) | 37 |
| TspRI | CASTG | 1 cut(s) | 310 |
| XapI | RAATTY | 2 cut(s) | 58, 222 |
| XspI | CTAG | 1 cut(s) | 120 |