Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 189 |
| AciI | CCGC | 1 cut(s) | 182 |
| AcsI | RAATTY | 2 cut(s) | 79, 243 |
| AdeI | CACNNNGTG | 1 cut(s) | 215 |
| AfaI | GTAC | 1 cut(s) | 139 |
| AhdI | GACNNNNNGTC | 2 cut(s) | 66, 263 |
| AluBI | AGCT | 1 cut(s) | 309 |
| AluI | AGCT | 1 cut(s) | 309 |
| ApoI | RAATTY | 2 cut(s) | 79, 243 |
| AspLEI | GCGC | 1 cut(s) | 76 |
| AsuHPI | GGTGA | 1 cut(s) | 70 |
| BccI | CCATC | 4 cut(s) | 95, 112, 230, 295 |
| BceAI | ACGGC | 1 cut(s) | 143 |
| BclI | TGATCA | 1 cut(s) | 3 |
| BfaI | CTAG | 1 cut(s) | 313 |
| BmeRI | GACNNNNNGTC | 2 cut(s) | 66, 263 |
| BmiI | GGNNCC | 1 cut(s) | 130 |
| BmsI | GCATC | 2 cut(s) | 21, 206 |
| BsaJI | CCNNGG | 1 cut(s) | 280 |
| Bse3DI | GCAATG | 1 cut(s) | 228 |
| BseDI | CCNNGG | 1 cut(s) | 280 |
| BseGI | GGATG | 2 cut(s) | 43, 123 |
| BseMI | GCAATG | 1 cut(s) | 228 |
| BseMII | CTCAG | 1 cut(s) | 42 |
| BslFI | GGGAC | 1 cut(s) | 183 |
| BsmFI | GGGAC | 1 cut(s) | 183 |
| Bsp143I | GATC | 1 cut(s) | 3 |
| BspACI | CCGC | 1 cut(s) | 182 |
| BspCNI | CTCAG | 1 cut(s) | 41 |
| BspHI | TCATGA | 1 cut(s) | 297 |
| BspLI | GGNNCC | 1 cut(s) | 130 |
| BsrDI | GCAATG | 1 cut(s) | 228 |
| BssECI | CCNNGG | 1 cut(s) | 280 |
| BssMI | GATC | 1 cut(s) | 3 |
| BssT1I | CCWWGG | 1 cut(s) | 280 |
| Bst4CI | ACNGT | 2 cut(s) | 64, 295 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 203 |
| BstDEI | CTNAG | 1 cut(s) | 28 |
| BstF5I | GGATG | 2 cut(s) | 43, 123 |
| BstHHI | GCGC | 1 cut(s) | 76 |
| BstKTI | GATC | 1 cut(s) | 6 |
| BstMBI | GATC | 1 cut(s) | 3 |
| BstMWI | GCNNNNNNNGC | 1 cut(s) | 203 |
| BtsCI | GGATG | 2 cut(s) | 43, 123 |
| CciI | TCATGA | 1 cut(s) | 297 |
| CfoI | GCGC | 1 cut(s) | 76 |
| Csp6I | GTAC | 1 cut(s) | 138 |
| CviAII | CATG | 1 cut(s) | 298 |
| CviJI | RGCY | 5 cut(s) | 92, 129, 272, 287, 309 |
| CviKI_1 | RGCY | 5 cut(s) | 92, 129, 272, 287, 309 |
| CviQI | GTAC | 1 cut(s) | 138 |
| DdeI | CTNAG | 1 cut(s) | 28 |
| DpnI | GATC | 1 cut(s) | 5 |
| DpnII | GATC | 1 cut(s) | 3 |
| DraIII | CACNNNGTG | 1 cut(s) | 215 |
| DriI | GACNNNNNGTC | 2 cut(s) | 66, 263 |
| Eam1105I | GACNNNNNGTC | 2 cut(s) | 66, 263 |
| Eco130I | CCWWGG | 1 cut(s) | 280 |
| EcoT14I | CCWWGG | 1 cut(s) | 280 |
| ErhI | CCWWGG | 1 cut(s) | 280 |
| FaeI | CATG | 1 cut(s) | 301 |
| FaiI | YATR | 2 cut(s) | 189, 299 |
| FaqI | GGGAC | 1 cut(s) | 183 |
| FatI | CATG | 1 cut(s) | 297 |
| FbaI | TGATCA | 1 cut(s) | 3 |
| FokI | GGATG | 2 cut(s) | 50, 130 |
| FspBI | CTAG | 1 cut(s) | 313 |
| GlaI | GCGC | 1 cut(s) | 75 |
| HhaI | GCGC | 1 cut(s) | 76 |
| Hin1II | CATG | 1 cut(s) | 301 |
| Hin6I | GCGC | 1 cut(s) | 74 |
| HinP1I | GCGC | 1 cut(s) | 74 |
| HindIII | AAGCTT | 1 cut(s) | 307 |
| HinfI | GANTC | 2 cut(s) | 67, 85 |
| HphI | GGTGA | 1 cut(s) | 70 |
| Hpy188I | TCNGA | 1 cut(s) | 31 |
| Hpy188III | TCNNGA | 3 cut(s) | 16, 255, 298 |
| Hpy99I | CGWCG | 1 cut(s) | 164 |
| HpyCH4III | ACNGT | 2 cut(s) | 64, 295 |
| HpyCH4V | TGCA | 2 cut(s) | 12, 197 |
| HpyF10VI | GCNNNNNNNGC | 1 cut(s) | 203 |
| HpyF3I | CTNAG | 1 cut(s) | 28 |
| Hsp92II | CATG | 1 cut(s) | 301 |
| HspAI | GCGC | 1 cut(s) | 74 |
| Ksp22I | TGATCA | 1 cut(s) | 3 |
| Kzo9I | GATC | 1 cut(s) | 3 |
| LmnI | GCTCC | 1 cut(s) | 134 |
| LpnPI | CCDG | 5 cut(s) | 56, 74, 111, 158, 240 |
| LweI | GCATC | 2 cut(s) | 21, 206 |
| MaeI | CTAG | 1 cut(s) | 313 |
| MaeIII | GTNAC | 1 cut(s) | 58 |
| MalI | GATC | 1 cut(s) | 5 |
| MboI | GATC | 1 cut(s) | 3 |
| MluCI | AATT | 3 cut(s) | 79, 243, 250 |
| MlyI | GAGTC | 1 cut(s) | 76 |
| MnlI | CCTC | 2 cut(s) | 102, 142 |
| MseI | TTAA | 1 cut(s) | 275 |
| MwoI | GCNNNNNNNGC | 1 cut(s) | 203 |
| NdeII | GATC | 1 cut(s) | 3 |
| NlaIII | CATG | 1 cut(s) | 301 |
| NlaIV | GGNNCC | 1 cut(s) | 130 |
| NmuCI | GTSAC | 1 cut(s) | 58 |
| PagI | TCATGA | 1 cut(s) | 297 |
| PfeI | GAWTC | 1 cut(s) | 85 |
| PleI | GAGTC | 1 cut(s) | 75 |
| PpsI | GAGTC | 1 cut(s) | 75 |
| PsiI | TTATAA | 1 cut(s) | 189 |
| PspN4I | GGNNCC | 1 cut(s) | 130 |
| RsaI | GTAC | 1 cut(s) | 139 |
| RsaNI | GTAC | 1 cut(s) | 138 |
| SaqAI | TTAA | 1 cut(s) | 275 |
| Sau3AI | GATC | 1 cut(s) | 3 |
| SchI | GAGTC | 1 cut(s) | 76 |
| SetI | ASST | 3 cut(s) | 153, 195, 311 |
| SfaNI | GCATC | 2 cut(s) | 21, 206 |
| Sse9I | AATT | 3 cut(s) | 79, 243, 250 |
| SsiI | CCGC | 1 cut(s) | 182 |
| SspMI | CTAG | 1 cut(s) | 313 |
| StyI | CCWWGG | 1 cut(s) | 280 |
| TaaI | ACNGT | 2 cut(s) | 64, 295 |
| TasI | AATT | 3 cut(s) | 79, 243, 250 |
| TatI | WGTACW | 1 cut(s) | 137 |
| TfiI | GAWTC | 1 cut(s) | 85 |
| Tru1I | TTAA | 1 cut(s) | 275 |
| Tru9I | TTAA | 1 cut(s) | 275 |
| TseFI | GTSAC | 1 cut(s) | 58 |
| Tsp45I | GTSAC | 1 cut(s) | 58 |
| XapI | RAATTY | 2 cut(s) | 79, 243 |
| XspI | CTAG | 1 cut(s) | 313 |