Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| IMPDH | PF00478 | 1 - 89 | 7.1e-14 | IMP dehydrogenase / GMP reductase domain |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AcuI | CTGAAG | 1 cut(s) | 86 |
| AfaI | GTAC | 2 cut(s) | 126, 131 |
| AflII | CTTAAG | 1 cut(s) | 202 |
| AgsI | TTSAA | 1 cut(s) | 14 |
| AjnI | CCWGG | 1 cut(s) | 208 |
| AluBI | AGCT | 2 cut(s) | 64, 242 |
| AluI | AGCT | 2 cut(s) | 64, 242 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 242 |
| ApeKI | GCWGC | 1 cut(s) | 242 |
| AspLEI | GCGC | 1 cut(s) | 173 |
| BanII | GRGCYC | 1 cut(s) | 8 |
| BbvI | GCAGC | 1 cut(s) | 229 |
| BciT130I | CCWGG | 1 cut(s) | 210 |
| BclI | TGATCA | 1 cut(s) | 34 |
| BfaI | CTAG | 1 cut(s) | 224 |
| BfmI | CTRYAG | 1 cut(s) | 182 |
| BfoI | RGCGCY | 1 cut(s) | 174 |
| BfrI | CTTAAG | 1 cut(s) | 202 |
| BglII | AGATCT | 1 cut(s) | 163 |
| BisI | GCNGC | 1 cut(s) | 243 |
| BlsI | GCNGC | 1 cut(s) | 244 |
| Bme1390I | CCNGG | 1 cut(s) | 210 |
| BmrFI | CCNGG | 1 cut(s) | 210 |
| BpuEI | CTTGAG | 1 cut(s) | 231 |
| BsaJI | CCNNGG | 1 cut(s) | 209 |
| BseBI | CCWGG | 1 cut(s) | 210 |
| BseDI | CCNNGG | 1 cut(s) | 209 |
| BseXI | GCAGC | 1 cut(s) | 229 |
| BsgI | GTGCAG | 1 cut(s) | 111 |
| Bsp1286I | GDGCHC | 1 cut(s) | 8 |
| Bsp143I | GATC | 2 cut(s) | 34, 163 |
| BspHI | TCATGA | 1 cut(s) | 193 |
| BspMAI | CTGCAG | 1 cut(s) | 186 |
| BspTI | CTTAAG | 1 cut(s) | 202 |
| BssECI | CCNNGG | 1 cut(s) | 209 |
| BssMI | GATC | 2 cut(s) | 34, 163 |
| Bst2UI | CCWGG | 1 cut(s) | 210 |
| Bst4CI | ACNGT | 1 cut(s) | 129 |
| BstAFI | CTTAAG | 1 cut(s) | 202 |
| BstC8I | GCNNGC | 1 cut(s) | 141 |
| BstH2I | RGCGCY | 1 cut(s) | 174 |
| BstHHI | GCGC | 1 cut(s) | 173 |
| BstKTI | GATC | 2 cut(s) | 37, 166 |
| BstMBI | GATC | 2 cut(s) | 34, 163 |
| BstNI | CCWGG | 1 cut(s) | 210 |
| BstSCI | CCNGG | 1 cut(s) | 208 |
| BstSFI | CTRYAG | 1 cut(s) | 182 |
| BstV1I | GCAGC | 1 cut(s) | 229 |
| BstX2I | RGATCY | 1 cut(s) | 163 |
| BstYI | RGATCY | 1 cut(s) | 163 |
| BtgZI | GCGATG | 1 cut(s) | 32 |
| BtsI | GCAGTG | 1 cut(s) | 150 |
| BtsIMutI | CAGTG | 1 cut(s) | 150 |
| Cac8I | GCNNGC | 1 cut(s) | 141 |
| CaiI | CAGNNNCTG | 1 cut(s) | 242 |
| CciI | TCATGA | 1 cut(s) | 193 |
| CfoI | GCGC | 1 cut(s) | 173 |
| Csp6I | GTAC | 2 cut(s) | 125, 130 |
| CviAII | CATG | 2 cut(s) | 194, 266 |
| CviJI | RGCY | 4 cut(s) | 6, 64, 223, 242 |
| CviKI_1 | RGCY | 4 cut(s) | 6, 64, 223, 242 |
| CviQI | GTAC | 2 cut(s) | 125, 130 |
| DpnI | GATC | 2 cut(s) | 36, 165 |
| DpnII | GATC | 2 cut(s) | 34, 163 |
| DraI | TTTAAA | 1 cut(s) | 117 |
| Eco24I | GRGCYC | 1 cut(s) | 8 |
| Eco57I | CTGAAG | 1 cut(s) | 86 |
| EcoRII | CCWGG | 1 cut(s) | 208 |
| EcoT38I | GRGCYC | 1 cut(s) | 8 |
| FaeI | CATG | 2 cut(s) | 197, 269 |
| FaiI | YATR | 2 cut(s) | 195, 267 |
| FatI | CATG | 2 cut(s) | 193, 265 |
| FbaI | TGATCA | 1 cut(s) | 34 |
| Fnu4HI | GCNGC | 1 cut(s) | 243 |
| FriOI | GRGCYC | 1 cut(s) | 8 |
| Fsp4HI | GCNGC | 1 cut(s) | 243 |
| FspBI | CTAG | 1 cut(s) | 224 |
| GlaI | GCGC | 1 cut(s) | 172 |
| GluI | GCNGC | 1 cut(s) | 243 |
| HaeII | RGCGCY | 1 cut(s) | 174 |
| HhaI | GCGC | 1 cut(s) | 173 |
| Hin1II | CATG | 2 cut(s) | 197, 269 |
| Hin6I | GCGC | 1 cut(s) | 171 |
| HinP1I | GCGC | 1 cut(s) | 171 |
| Hpy166II | GTNNAC | 1 cut(s) | 132 |
| Hpy188III | TCNNGA | 2 cut(s) | 11, 194 |
| Hpy8I | GTNNAC | 1 cut(s) | 132 |
| HpyAV | CCTTC | 1 cut(s) | 248 |
| HpyCH4III | ACNGT | 1 cut(s) | 129 |
| HpyCH4V | TGCA | 5 cut(s) | 74, 92, 98, 139, 184 |
| Hsp92II | CATG | 2 cut(s) | 197, 269 |
| HspAI | GCGC | 1 cut(s) | 171 |
| Ksp22I | TGATCA | 1 cut(s) | 34 |
| Kzo9I | GATC | 2 cut(s) | 34, 163 |
| LmnI | GCTCC | 1 cut(s) | 239 |
| LpnPI | CCDG | 5 cut(s) | 32, 62, 195, 222, 222 |
| Lsp1109I | GCAGC | 1 cut(s) | 229 |
| MaeI | CTAG | 1 cut(s) | 224 |
| MalI | GATC | 2 cut(s) | 36, 165 |
| MboI | GATC | 2 cut(s) | 34, 163 |
| MboII | GAAGA | 3 cut(s) | 79, 168, 298 |
| MflI | RGATCY | 1 cut(s) | 163 |
| MhlI | GDGCHC | 1 cut(s) | 8 |
| MnlI | CCTC | 2 cut(s) | 209, 220 |
| MseI | TTAA | 3 cut(s) | 116, 203, 218 |
| MspCI | CTTAAG | 1 cut(s) | 202 |
| MspR9I | CCNGG | 1 cut(s) | 210 |
| MvaI | CCWGG | 1 cut(s) | 210 |
| NdeII | GATC | 2 cut(s) | 34, 163 |
| NlaIII | CATG | 2 cut(s) | 197, 269 |
| NmeAIII | GCCGAG | 1 cut(s) | 147 |
| PagI | TCATGA | 1 cut(s) | 193 |
| PkrI | GCNGC | 1 cut(s) | 244 |
| Psp6I | CCWGG | 1 cut(s) | 208 |
| PspGI | CCWGG | 1 cut(s) | 208 |
| PstI | CTGCAG | 1 cut(s) | 186 |
| PstNI | CAGNNNCTG | 1 cut(s) | 242 |
| PsuI | RGATCY | 1 cut(s) | 163 |
| RsaI | GTAC | 2 cut(s) | 126, 131 |
| RsaNI | GTAC | 2 cut(s) | 125, 130 |
| SaqAI | TTAA | 3 cut(s) | 116, 203, 218 |
| SatI | GCNGC | 1 cut(s) | 243 |
| Sau3AI | GATC | 2 cut(s) | 34, 163 |
| ScrFI | CCNGG | 1 cut(s) | 210 |
| SduI | GDGCHC | 1 cut(s) | 8 |
| SetI | ASST | 8 cut(s) | 44, 66, 109, 157, 201, 231, 244, 259 |
| SfcI | CTRYAG | 1 cut(s) | 182 |
| SmlI | CTYRAG | 2 cut(s) | 202, 246 |
| SmoI | CTYRAG | 2 cut(s) | 202, 246 |
| SspMI | CTAG | 1 cut(s) | 224 |
| StyD4I | CCNGG | 1 cut(s) | 208 |
| TaaI | ACNGT | 1 cut(s) | 129 |
| Tru1I | TTAA | 3 cut(s) | 116, 203, 218 |
| Tru9I | TTAA | 3 cut(s) | 116, 203, 218 |
| TscAI | CASTG | 1 cut(s) | 150 |
| TseI | GCWGC | 1 cut(s) | 242 |
| TspDTI | ATGAA | 1 cut(s) | 254 |
| TspRI | CASTG | 1 cut(s) | 150 |
| Vha464I | CTTAAG | 1 cut(s) | 202 |
| XspI | CTAG | 1 cut(s) | 224 |