The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| Proteasome | PF00227 | 35 - 251 | 1.4e-08 | Proteasome subunit |
Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AasI | GACNNNNNNGTC | 1 cut(s) | 577 |
| AatII | GACGTC | 2 cut(s) | 362, 1059 |
| AccB1I | GGYRCC | 1 cut(s) | 94 |
| AccBSI | CCGCTC | 1 cut(s) | 631 |
| AccI | GTMKAC | 2 cut(s) | 129, 488 |
| AciI | CCGC | 8 cut(s) | 135, 153, 587, 596, 631, 710, 732, 778 |
| AclI | AACGTT | 1 cut(s) | 185 |
| AclWI | GGATC | 1 cut(s) | 713 |
| AcsI | RAATTY | 3 cut(s) | 115, 590, 736 |
| AcuI | CTGAAG | 1 cut(s) | 1124 |
| AcyI | GRCGYC | 2 cut(s) | 359, 1056 |
| AdeI | CACNNNGTG | 1 cut(s) | 299 |
| AfaI | GTAC | 2 cut(s) | 725, 1135 |
| AfiI | CCNNNNNNNGG | 2 cut(s) | 104, 728 |
| AflIII | ACRYGT | 1 cut(s) | 1208 |
| AgsI | TTSAA | 7 cut(s) | 64, 215, 233, 311, 368, 962, 1021 |
| AjnI | CCWGG | 1 cut(s) | 1201 |
| AjuI | GAANNNNNNNTTGG | 2 cut(s) | 900, 932 |
| AluBI | AGCT | 5 cut(s) | 171, 386, 831, 1066, 1215 |
| AluI | AGCT | 5 cut(s) | 171, 386, 831, 1066, 1215 |
| Alw21I | GWGCWC | 1 cut(s) | 777 |
| Alw26I | GTCTC | 2 cut(s) | 563, 831 |
| AlwI | GGATC | 1 cut(s) | 713 |
| Ama87I | CYCGRG | 2 cut(s) | 575, 727 |
| AoxI | GGCC | 3 cut(s) | 875, 929, 1079 |
| ApeKI | GCWGC | 1 cut(s) | 707 |
| ApoI | RAATTY | 3 cut(s) | 115, 590, 736 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 344, 376 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 13 |
| AspS9I | GGNCC | 3 cut(s) | 1079, 1160, 1250 |
| AsuHPI | GGTGA | 2 cut(s) | 497, 950 |
| AvaI | CYCGRG | 2 cut(s) | 575, 727 |
| AvaII | GGWCC | 2 cut(s) | 1160, 1250 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 247, 280 |
| BanI | GGYRCC | 1 cut(s) | 94 |
| BanII | GRGCYC | 1 cut(s) | 1039 |
| BarI | GAAGNNNNNNTAC | 2 cut(s) | 360, 392 |
| BauI | CACGAG | 1 cut(s) | 714 |
| BbsI | GAAGAC | 1 cut(s) | 1104 |
| Bbv12I | GWGCWC | 1 cut(s) | 777 |
| BbvI | GCAGC | 1 cut(s) | 719 |
| BccI | CCATC | 3 cut(s) | 75, 85, 1178 |
| BceAI | ACGGC | 1 cut(s) | 82 |
| BciT130I | CCWGG | 1 cut(s) | 1203 |
| BciVI | GTATCC | 1 cut(s) | 1155 |
| BcoDI | GTCTC | 2 cut(s) | 563, 831 |
| BfuI | GTATCC | 1 cut(s) | 1155 |
| BglII | AGATCT | 3 cut(s) | 612, 851, 1072 |
| BisI | GCNGC | 2 cut(s) | 708, 711 |
| BlsI | GCNGC | 2 cut(s) | 709, 712 |
| Bme1390I | CCNGG | 1 cut(s) | 1203 |
| Bme18I | GGWCC | 2 cut(s) | 1160, 1250 |
| BmeT110I | CYCGRG | 2 cut(s) | 575, 727 |
| BmgT120I | GGNCC | 3 cut(s) | 1079, 1160, 1250 |
| BmiI | GGNNCC | 2 cut(s) | 96, 1162 |
| BmrFI | CCNGG | 1 cut(s) | 1203 |
| BmsI | GCATC | 1 cut(s) | 361 |
| BpiI | GAAGAC | 1 cut(s) | 1104 |
| Bsa29I | ATCGAT | 1 cut(s) | 843 |
| BsaAI | YACGTR | 2 cut(s) | 409, 1211 |
| BsaHI | GRCGYC | 2 cut(s) | 359, 1056 |
| BsaJI | CCNNGG | 2 cut(s) | 498, 1202 |
| BsaWI | WCCGGW | 2 cut(s) | 457, 1147 |
| BsaXI | ACNNNNNCTCC | 4 cut(s) | 129, 159, 767, 797 |
| Bsc4I | CCNNNNNNNGG | 2 cut(s) | 104, 728 |
| Bse1I | ACTGG | 1 cut(s) | 1174 |
| BseBI | CCWGG | 1 cut(s) | 1203 |
| BseCI | ATCGAT | 1 cut(s) | 843 |
| BseDI | CCNNGG | 2 cut(s) | 498, 1202 |
| BseGI | GGATG | 4 cut(s) | 67, 604, 958, 1170 |
| BseLI | CCNNNNNNNGG | 2 cut(s) | 104, 728 |
| BseMII | CTCAG | 3 cut(s) | 60, 78, 558 |
| BseNI | ACTGG | 1 cut(s) | 1174 |
| BseRI | GAGGAG | 1 cut(s) | 641 |
| BseXI | GCAGC | 1 cut(s) | 719 |
| BseYI | CCCAGC | 1 cut(s) | 1163 |
| BsgI | GTGCAG | 1 cut(s) | 226 |
| Bsh1285I | CGRYCG | 1 cut(s) | 1130 |
| BshFI | GGCC | 3 cut(s) | 877, 931, 1081 |
| BshNI | GGYRCC | 1 cut(s) | 94 |
| BshVI | ATCGAT | 1 cut(s) | 843 |
| BsiEI | CGRYCG | 1 cut(s) | 1130 |
| BsiHKAI | GWGCWC | 1 cut(s) | 777 |
| BsiHKCI | CYCGRG | 2 cut(s) | 575, 727 |
| BsiSI | CCGG | 2 cut(s) | 458, 1148 |
| BslFI | GGGAC | 3 cut(s) | 121, 170, 1219 |
| BslI | CCNNNNNNNGG | 2 cut(s) | 104, 728 |
| BsmAI | GTCTC | 2 cut(s) | 563, 831 |
| BsmFI | GGGAC | 3 cut(s) | 121, 170, 1219 |
| BsnI | GGCC | 3 cut(s) | 877, 931, 1081 |
| BsoBI | CYCGRG | 2 cut(s) | 575, 727 |
| Bsp1286I | GDGCHC | 2 cut(s) | 777, 1039 |
| Bsp143I | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| BspACI | CCGC | 8 cut(s) | 135, 153, 587, 596, 631, 710, 732, 778 |
| BspANI | GGCC | 3 cut(s) | 877, 931, 1081 |
| BspCNI | CTCAG | 3 cut(s) | 59, 79, 559 |
| BspDI | ATCGAT | 1 cut(s) | 843 |
| BspLI | GGNNCC | 2 cut(s) | 96, 1162 |
| BspPI | GGATC | 1 cut(s) | 713 |
| BspT107I | GGYRCC | 1 cut(s) | 94 |
| BsrBI | CCGCTC | 1 cut(s) | 631 |
| BsrI | ACTGG | 1 cut(s) | 1174 |
| BssECI | CCNNGG | 2 cut(s) | 498, 1202 |
| BssMI | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| BssNAI | GTATAC | 2 cut(s) | 130, 489 |
| BssNI | GRCGYC | 2 cut(s) | 359, 1056 |
| BssSI | CACGAG | 1 cut(s) | 714 |
| Bst1107I | GTATAC | 2 cut(s) | 130, 489 |
| Bst2BI | CACGAG | 1 cut(s) | 714 |
| Bst2UI | CCWGG | 1 cut(s) | 1203 |
| Bst4CI | ACNGT | 6 cut(s) | 161, 493, 541, 563, 867, 895 |
| Bst6I | CTCTTC | 2 cut(s) | 1022, 1143 |
| BstACI | GRCGYC | 2 cut(s) | 359, 1056 |
| BstBAI | YACGTR | 2 cut(s) | 409, 1211 |
| BstC8I | GCNNGC | 3 cut(s) | 672, 1068, 1217 |
| BstDEI | CTNAG | 6 cut(s) | 46, 87, 172, 345, 398, 567 |
| BstEII | GGTNACC | 1 cut(s) | 503 |
| BstF5I | GGATG | 4 cut(s) | 67, 604, 958, 1170 |
| BstKTI | GATC | 8 cut(s) | 480, 532, 615, 721, 854, 958, 1075, 1130 |
| BstMAI | GTCTC | 2 cut(s) | 563, 831 |
| BstMBI | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| BstMCI | CGRYCG | 1 cut(s) | 1130 |
| BstMWI | GCNNNNNNNGC | 3 cut(s) | 593, 1043, 1198 |
| BstNI | CCWGG | 1 cut(s) | 1203 |
| BstNSI | RCATGY | 4 cut(s) | 36, 262, 1192, 1201 |
| BstPI | GGTNACC | 1 cut(s) | 503 |
| BstSCI | CCNGG | 1 cut(s) | 1201 |
| BstV1I | GCAGC | 1 cut(s) | 719 |
| BstV2I | GAAGAC | 1 cut(s) | 1104 |
| BstX2I | RGATCY | 3 cut(s) | 612, 851, 1072 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 793 |
| BstYI | RGATCY | 3 cut(s) | 612, 851, 1072 |
| BstZ17I | GTATAC | 2 cut(s) | 130, 489 |
| Bsu15I | ATCGAT | 1 cut(s) | 843 |
| BsuI | GTATCC | 1 cut(s) | 1155 |
| BsuRI | GGCC | 3 cut(s) | 877, 931, 1081 |
| BsuTUI | ATCGAT | 1 cut(s) | 843 |
| BtgZI | GCGATG | 1 cut(s) | 992 |
| BtsCI | GGATG | 4 cut(s) | 67, 604, 958, 1170 |
| BtsIMutI | CAGTG | 1 cut(s) | 568 |
| Cac8I | GCNNGC | 3 cut(s) | 672, 1068, 1217 |
| Cfr13I | GGNCC | 3 cut(s) | 1079, 1160, 1250 |
| ClaI | ATCGAT | 1 cut(s) | 843 |
| Csp6I | GTAC | 2 cut(s) | 724, 1134 |
| CviAII | CATG | 6 cut(s) | 33, 259, 439, 448, 1189, 1198 |
| CviQI | GTAC | 2 cut(s) | 724, 1134 |
| DdeI | CTNAG | 6 cut(s) | 46, 87, 172, 345, 398, 567 |
| DpnI | GATC | 8 cut(s) | 479, 531, 614, 720, 853, 957, 1074, 1129 |
| DpnII | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| DraI | TTTAAA | 1 cut(s) | 181 |
| DraIII | CACNNNGTG | 1 cut(s) | 299 |
| DrdI | GACNNNNNNGTC | 1 cut(s) | 577 |
| DseDI | GACNNNNNNGTC | 1 cut(s) | 577 |
| Eam1104I | CTCTTC | 2 cut(s) | 1022, 1143 |
| EarI | CTCTTC | 2 cut(s) | 1022, 1143 |
| EciI | GGCGGA | 2 cut(s) | 602, 747 |
| Eco24I | GRGCYC | 1 cut(s) | 1039 |
| Eco32I | GATATC | 1 cut(s) | 997 |
| Eco47I | GGWCC | 2 cut(s) | 1160, 1250 |
| Eco57I | CTGAAG | 1 cut(s) | 1124 |
| Eco88I | CYCGRG | 2 cut(s) | 575, 727 |
| Eco91I | GGTNACC | 1 cut(s) | 503 |
| EcoO65I | GGTNACC | 1 cut(s) | 503 |
| EcoRII | CCWGG | 1 cut(s) | 1201 |
| EcoRV | GATATC | 1 cut(s) | 997 |
| EcoT38I | GRGCYC | 1 cut(s) | 1039 |
| FaeI | CATG | 6 cut(s) | 36, 262, 442, 451, 1192, 1201 |
| FalI | AAGNNNNNCTT | 2 cut(s) | 1095, 1127 |
| FaqI | GGGAC | 3 cut(s) | 121, 170, 1219 |
| FatI | CATG | 6 cut(s) | 32, 258, 438, 447, 1188, 1197 |
| FauI | CCCGC | 2 cut(s) | 146, 624 |
| FauNDI | CATATG | 2 cut(s) | 640, 802 |
| FblI | GTMKAC | 2 cut(s) | 129, 488 |
| Fnu4HI | GCNGC | 2 cut(s) | 708, 711 |
| FokI | GGATG | 4 cut(s) | 54, 611, 965, 1157 |
| FriOI | GRGCYC | 1 cut(s) | 1039 |
| Fsp4HI | GCNGC | 2 cut(s) | 708, 711 |
| GluI | GCNGC | 2 cut(s) | 708, 711 |
| GsaI | CCCAGC | 1 cut(s) | 1167 |
| HaeIII | GGCC | 3 cut(s) | 877, 931, 1081 |
| HapII | CCGG | 2 cut(s) | 458, 1148 |
| Hin1I | GRCGYC | 2 cut(s) | 359, 1056 |
| Hin1II | CATG | 6 cut(s) | 36, 262, 442, 451, 1192, 1201 |
| HincII | GTYRAC | 1 cut(s) | 1060 |
| HindII | GTYRAC | 1 cut(s) | 1060 |
| HindIII | AAGCTT | 1 cut(s) | 384 |
| HinfI | GANTC | 2 cut(s) | 221, 819 |
| HpaII | CCGG | 2 cut(s) | 458, 1148 |
| HphI | GGTGA | 2 cut(s) | 497, 950 |
| Hpy166II | GTNNAC | 3 cut(s) | 130, 489, 1060 |
| Hpy188I | TCNGA | 6 cut(s) | 49, 88, 254, 470, 836, 994 |
| Hpy188III | TCNNGA | 3 cut(s) | 527, 690, 716 |
| Hpy8I | GTNNAC | 3 cut(s) | 130, 489, 1060 |
| Hpy99I | CGWCG | 1 cut(s) | 1058 |
| HpyAV | CCTTC | 3 cut(s) | 273, 641, 1022 |
| HpyCH4III | ACNGT | 6 cut(s) | 161, 493, 541, 563, 867, 895 |
| HpyCH4IV | ACGT | 5 cut(s) | 185, 359, 408, 1056, 1210 |
| HpyCH4V | TGCA | 7 cut(s) | 26, 102, 243, 291, 707, 899, 1219 |
| HpyF10VI | GCNNNNNNNGC | 3 cut(s) | 593, 1043, 1198 |
| HpyF3I | CTNAG | 6 cut(s) | 46, 87, 172, 345, 398, 567 |
| HpySE526I | ACGT | 5 cut(s) | 185, 359, 408, 1056, 1210 |
| Hsp92I | GRCGYC | 2 cut(s) | 359, 1056 |
| Hsp92II | CATG | 6 cut(s) | 36, 262, 442, 451, 1192, 1201 |
| Kzo9I | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| LmnI | GCTCC | 1 cut(s) | 628 |
| Lsp1109I | GCAGC | 1 cut(s) | 719 |
| LweI | GCATC | 1 cut(s) | 361 |
| MaeII | ACGT | 5 cut(s) | 185, 359, 408, 1056, 1210 |
| MaeIII | GTNAC | 4 cut(s) | 266, 355, 503, 520 |
| MalI | GATC | 8 cut(s) | 479, 531, 614, 720, 853, 957, 1074, 1129 |
| MbiI | CCGCTC | 1 cut(s) | 631 |
| MboI | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| MboII | GAAGA | 6 cut(s) | 245, 380, 950, 1009, 1109, 1130 |
| MfeI | CAATTG | 2 cut(s) | 363, 1245 |
| MflI | RGATCY | 3 cut(s) | 612, 851, 1072 |
| MhlI | GDGCHC | 2 cut(s) | 777, 1039 |
| MluCI | AATT | 8 cut(s) | 115, 363, 590, 736, 787, 1090, 1245, 1254 |
| MlyI | GAGTC | 2 cut(s) | 230, 813 |
| MmeI | TCCRAC | 3 cut(s) | 869, 972, 1138 |
| MnlI | CCTC | 9 cut(s) | 28, 131, 269, 400, 493, 543, 619, 628, 934 |
| MroXI | GAANNNNTTC | 1 cut(s) | 13 |
| MseI | TTAA | 1 cut(s) | 180 |
| MspA1I | CMGCKG | 3 cut(s) | 135, 710, 1066 |
| MspI | CCGG | 2 cut(s) | 458, 1148 |
| MspR9I | CCNGG | 1 cut(s) | 1203 |
| MunI | CAATTG | 2 cut(s) | 363, 1245 |
| MvaI | CCWGG | 1 cut(s) | 1203 |
| MwoI | GCNNNNNNNGC | 3 cut(s) | 593, 1043, 1198 |
| NdeI | CATATG | 2 cut(s) | 640, 802 |
| NdeII | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| NlaIII | CATG | 6 cut(s) | 36, 262, 442, 451, 1192, 1201 |
| NlaIV | GGNNCC | 2 cut(s) | 96, 1162 |
| NmeAIII | GCCGAG | 1 cut(s) | 523 |
| NmuCI | GTSAC | 2 cut(s) | 355, 503 |
| NspI | RCATGY | 4 cut(s) | 36, 262, 1192, 1201 |
| PcsI | WCGNNNNNNNCGW | 1 cut(s) | 840 |
| PdmI | GAANNNNTTC | 1 cut(s) | 13 |
| PkrI | GCNGC | 2 cut(s) | 709, 712 |
| Ple19I | CGATCG | 1 cut(s) | 1130 |
| PleI | GAGTC | 2 cut(s) | 229, 813 |
| PpsI | GAGTC | 2 cut(s) | 229, 813 |
| Ppu21I | YACGTR | 2 cut(s) | 409, 1211 |
| Psp1406I | AACGTT | 1 cut(s) | 185 |
| Psp6I | CCWGG | 1 cut(s) | 1201 |
| PspEI | GGTNACC | 1 cut(s) | 503 |
| PspFI | CCCAGC | 1 cut(s) | 1163 |
| PspGI | CCWGG | 1 cut(s) | 1201 |
| PspN4I | GGNNCC | 2 cut(s) | 96, 1162 |
| PspPI | GGNCC | 3 cut(s) | 1079, 1160, 1250 |
| PsuI | RGATCY | 3 cut(s) | 612, 851, 1072 |
| PvuI | CGATCG | 1 cut(s) | 1130 |
| PvuII | CAGCTG | 1 cut(s) | 1066 |
| RsaI | GTAC | 2 cut(s) | 725, 1135 |
| RsaNI | GTAC | 2 cut(s) | 724, 1134 |
| SaqAI | TTAA | 1 cut(s) | 180 |
| SatI | GCNGC | 2 cut(s) | 708, 711 |
| Sau3AI | GATC | 8 cut(s) | 477, 529, 612, 718, 851, 955, 1072, 1127 |
| Sau96I | GGNCC | 3 cut(s) | 1079, 1160, 1250 |
| SchI | GAGTC | 2 cut(s) | 230, 813 |
| ScrFI | CCNGG | 1 cut(s) | 1203 |
| SduI | GDGCHC | 2 cut(s) | 777, 1039 |
| SfaNI | GCATC | 1 cut(s) | 361 |
| SinI | GGWCC | 2 cut(s) | 1160, 1250 |
| Sse9I | AATT | 8 cut(s) | 115, 363, 590, 736, 787, 1090, 1245, 1254 |
| SsiI | CCGC | 8 cut(s) | 135, 153, 587, 596, 631, 710, 732, 778 |
| StyD4I | CCNGG | 1 cut(s) | 1201 |
| TaaI | ACNGT | 6 cut(s) | 161, 493, 541, 563, 867, 895 |
| TaiI | ACGT | 5 cut(s) | 188, 362, 411, 1059, 1213 |
| TaqI | TCGA | 5 cut(s) | 274, 528, 691, 825, 843 |
| TasI | AATT | 8 cut(s) | 115, 363, 590, 736, 787, 1090, 1245, 1254 |
| TauI | GCSGC | 1 cut(s) | 713 |
| Tru1I | TTAA | 1 cut(s) | 180 |
| Tru9I | TTAA | 1 cut(s) | 180 |
| TscAI | CASTG | 1 cut(s) | 568 |
| TseFI | GTSAC | 2 cut(s) | 355, 503 |
| TseI | GCWGC | 1 cut(s) | 707 |
| Tsp45I | GTSAC | 2 cut(s) | 355, 503 |
| TspDTI | ATGAA | 6 cut(s) | 436, 455, 533, 740, 789, 995 |
| TspGWI | ACGGA | 1 cut(s) | 711 |
| TspRI | CASTG | 1 cut(s) | 568 |
| VpaK11BI | GGWCC | 2 cut(s) | 1160, 1250 |
| XapI | RAATTY | 3 cut(s) | 115, 590, 736 |
| XceI | RCATGY | 4 cut(s) | 36, 262, 1192, 1201 |
| XmiI | GTMKAC | 2 cut(s) | 129, 488 |
| XmnI | GAANNNNTTC | 1 cut(s) | 13 |
| ZraI | GACGTC | 2 cut(s) | 360, 1057 |