E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| Sina_ZnF | PF21361 | 203 - 266 | 6.3e-11 | Sina, zinc finger |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 2 cut(s) | 585, 1082 |
| AatII | GACGTC | 1 cut(s) | 70 |
| AciI | CCGC | 2 cut(s) | 21, 263 |
| AcoI | YGGCCR | 2 cut(s) | 354, 1111 |
| AcsI | RAATTY | 3 cut(s) | 245, 857, 918 |
| AcuI | CTGAAG | 2 cut(s) | 255, 441 |
| AcyI | GRCGYC | 1 cut(s) | 67 |
| AfaI | GTAC | 1 cut(s) | 818 |
| AfiI | CCNNNNNNNGG | 2 cut(s) | 333, 734 |
| AflIII | ACRYGT | 2 cut(s) | 475, 806 |
| AgsI | TTSAA | 5 cut(s) | 756, 796, 834, 872, 953 |
| AjnI | CCWGG | 4 cut(s) | 53, 414, 569, 1087 |
| AluBI | AGCT | 5 cut(s) | 89, 302, 521, 828, 1117 |
| AluI | AGCT | 5 cut(s) | 89, 302, 521, 828, 1117 |
| Alw26I | GTCTC | 3 cut(s) | 58, 302, 754 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 434 |
| AoxI | GGCC | 3 cut(s) | 354, 572, 1111 |
| ApeKI | GCWGC | 6 cut(s) | 48, 89, 299, 534, 738, 825 |
| ApoI | RAATTY | 3 cut(s) | 245, 857, 918 |
| AspS9I | GGNCC | 3 cut(s) | 41, 270, 573 |
| AsuC2I | CCSGG | 1 cut(s) | 362 |
| AsuHPI | GGTGA | 5 cut(s) | 251, 340, 705, 946, 1103 |
| AvaII | GGWCC | 2 cut(s) | 41, 270 |
| BalI | TGGCCA | 1 cut(s) | 1113 |
| BarI | GAAGNNNNNNTAC | 2 cut(s) | 752, 784 |
| BauI | CACGAG | 1 cut(s) | 257 |
| BbsI | GAAGAC | 1 cut(s) | 403 |
| BbvI | GCAGC | 6 cut(s) | 60, 76, 311, 546, 725, 837 |
| BccI | CCATC | 6 cut(s) | 26, 353, 410, 661, 878, 1117 |
| BciT130I | CCWGG | 4 cut(s) | 55, 416, 571, 1089 |
| BcnI | CCSGG | 1 cut(s) | 362 |
| BcoDI | GTCTC | 3 cut(s) | 58, 302, 754 |
| BfaI | CTAG | 3 cut(s) | 614, 923, 957 |
| BfmI | CTRYAG | 2 cut(s) | 128, 532 |
| BisI | GCNGC | 7 cut(s) | 49, 90, 263, 300, 535, 739, 826 |
| BlsI | GCNGC | 7 cut(s) | 50, 91, 264, 301, 536, 740, 827 |
| Bme1390I | CCNGG | 5 cut(s) | 55, 362, 416, 571, 1089 |
| Bme18I | GGWCC | 2 cut(s) | 41, 270 |
| BmgT120I | GGNCC | 3 cut(s) | 41, 270, 573 |
| BmrFI | CCNGG | 5 cut(s) | 55, 362, 416, 571, 1089 |
| BpiI | GAAGAC | 1 cut(s) | 403 |
| BpuEI | CTTGAG | 2 cut(s) | 288, 1103 |
| BpuMI | CCSGG | 1 cut(s) | 362 |
| BsaBI | GATNNNNATC | 1 cut(s) | 1127 |
| BsaHI | GRCGYC | 1 cut(s) | 67 |
| BsaJI | CCNNGG | 7 cut(s) | 53, 266, 294, 327, 351, 999, 1087 |
| Bsc4I | CCNNNNNNNGG | 2 cut(s) | 333, 734 |
| Bse8I | GATNNNNATC | 1 cut(s) | 1127 |
| BseBI | CCWGG | 4 cut(s) | 55, 416, 571, 1089 |
| BseDI | CCNNGG | 7 cut(s) | 53, 266, 294, 327, 351, 999, 1087 |
| BseGI | GGATG | 5 cut(s) | 152, 370, 402, 672, 1010 |
| BseJI | GATNNNNATC | 1 cut(s) | 1127 |
| BseLI | CCNNNNNNNGG | 2 cut(s) | 333, 734 |
| BseMII | CTCAG | 1 cut(s) | 1027 |
| BseRI | GAGGAG | 3 cut(s) | 132, 135, 517 |
| BseXI | GCAGC | 6 cut(s) | 60, 76, 311, 546, 725, 837 |
| BshFI | GGCC | 3 cut(s) | 356, 574, 1113 |
| BsiSI | CCGG | 1 cut(s) | 362 |
| BslI | CCNNNNNNNGG | 2 cut(s) | 333, 734 |
| BsmAI | GTCTC | 3 cut(s) | 58, 302, 754 |
| BsmBI | CGTCTC | 1 cut(s) | 58 |
| BsmI | GAATGC | 1 cut(s) | 709 |
| BsnI | GGCC | 3 cut(s) | 356, 574, 1113 |
| Bsp1407I | TGTACA | 1 cut(s) | 816 |
| Bsp143I | GATC | 1 cut(s) | 982 |
| BspACI | CCGC | 2 cut(s) | 21, 263 |
| BspANI | GGCC | 3 cut(s) | 356, 574, 1113 |
| BspCNI | CTCAG | 1 cut(s) | 1026 |
| BspHI | TCATGA | 1 cut(s) | 466 |
| BspMAI | CTGCAG | 1 cut(s) | 536 |
| BsrGI | TGTACA | 1 cut(s) | 816 |
| BssECI | CCNNGG | 7 cut(s) | 53, 266, 294, 327, 351, 999, 1087 |
| BssMI | GATC | 1 cut(s) | 982 |
| BssNI | GRCGYC | 1 cut(s) | 67 |
| BssSI | CACGAG | 1 cut(s) | 257 |
| BssT1I | CCWWGG | 2 cut(s) | 351, 999 |
| Bst2BI | CACGAG | 1 cut(s) | 257 |
| Bst2UI | CCWGG | 4 cut(s) | 55, 416, 571, 1089 |
| Bst4CI | ACNGT | 2 cut(s) | 97, 1023 |
| Bst6I | CTCTTC | 3 cut(s) | 56, 165, 757 |
| BstACI | GRCGYC | 1 cut(s) | 67 |
| BstAUI | TGTACA | 1 cut(s) | 816 |
| BstC8I | GCNNGC | 3 cut(s) | 523, 673, 1115 |
| BstDEI | CTNAG | 2 cut(s) | 941, 1013 |
| BstDSI | CCRYGG | 1 cut(s) | 327 |
| BstENI | CCTNNNNNAGG | 1 cut(s) | 732 |
| BstF5I | GGATG | 5 cut(s) | 152, 370, 402, 672, 1010 |
| BstKTI | GATC | 1 cut(s) | 985 |
| BstMAI | GTCTC | 3 cut(s) | 58, 302, 754 |
| BstMBI | GATC | 1 cut(s) | 982 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 98, 299, 384, 531 |
| BstNI | CCWGG | 4 cut(s) | 55, 416, 571, 1089 |
| BstNSI | RCATGY | 2 cut(s) | 479, 705 |
| BstSCI | CCNGG | 5 cut(s) | 53, 360, 414, 569, 1087 |
| BstSFI | CTRYAG | 2 cut(s) | 128, 532 |
| BstV1I | GCAGC | 6 cut(s) | 60, 76, 311, 546, 725, 837 |
| BstV2I | GAAGAC | 1 cut(s) | 403 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 352 |
| BsuRI | GGCC | 3 cut(s) | 356, 574, 1113 |
| BtgI | CCRYGG | 1 cut(s) | 327 |
| BtsCI | GGATG | 5 cut(s) | 152, 370, 402, 672, 1010 |
| Cac8I | GCNNGC | 3 cut(s) | 523, 673, 1115 |
| CaiI | CAGNNNCTG | 1 cut(s) | 434 |
| CciI | TCATGA | 1 cut(s) | 466 |
| Cfr13I | GGNCC | 3 cut(s) | 41, 270, 573 |
| Csp6I | GTAC | 1 cut(s) | 817 |
| CviQI | GTAC | 1 cut(s) | 817 |
| DdeI | CTNAG | 2 cut(s) | 941, 1013 |
| DpnI | GATC | 1 cut(s) | 984 |
| DpnII | GATC | 1 cut(s) | 982 |
| EaeI | YGGCCR | 2 cut(s) | 354, 1111 |
| Eam1104I | CTCTTC | 3 cut(s) | 56, 165, 757 |
| EarI | CTCTTC | 3 cut(s) | 56, 165, 757 |
| EciI | GGCGGA | 1 cut(s) | 36 |
| Eco130I | CCWWGG | 2 cut(s) | 351, 999 |
| Eco32I | GATATC | 1 cut(s) | 1129 |
| Eco47I | GGWCC | 2 cut(s) | 41, 270 |
| Eco57I | CTGAAG | 2 cut(s) | 255, 441 |
| EcoNI | CCTNNNNNAGG | 1 cut(s) | 732 |
| EcoRI | GAATTC | 1 cut(s) | 245 |
| EcoRII | CCWGG | 4 cut(s) | 53, 414, 569, 1087 |
| EcoRV | GATATC | 1 cut(s) | 1129 |
| EcoT14I | CCWWGG | 2 cut(s) | 351, 999 |
| EcoT22I | ATGCAT | 1 cut(s) | 711 |
| ErhI | CCWWGG | 2 cut(s) | 351, 999 |
| Esp3I | CGTCTC | 1 cut(s) | 58 |
| FauNDI | CATATG | 1 cut(s) | 1136 |
| Fnu4HI | GCNGC | 7 cut(s) | 49, 90, 263, 300, 535, 739, 826 |
| FokI | GGATG | 5 cut(s) | 139, 377, 389, 679, 1017 |
| Fsp4HI | GCNGC | 7 cut(s) | 49, 90, 263, 300, 535, 739, 826 |
| FspBI | CTAG | 3 cut(s) | 614, 923, 957 |
| GluI | GCNGC | 7 cut(s) | 49, 90, 263, 300, 535, 739, 826 |
| HaeIII | GGCC | 3 cut(s) | 356, 574, 1113 |
| HapII | CCGG | 1 cut(s) | 362 |
| Hin1I | GRCGYC | 1 cut(s) | 67 |
| HinfI | GANTC | 5 cut(s) | 9, 146, 200, 392, 617 |
| HpaII | CCGG | 1 cut(s) | 362 |
| HphI | GGTGA | 5 cut(s) | 251, 340, 705, 946, 1103 |
| Hpy166II | GTNNAC | 1 cut(s) | 1010 |
| Hpy188I | TCNGA | 5 cut(s) | 84, 157, 205, 436, 1016 |
| Hpy188III | TCNNGA | 5 cut(s) | 305, 467, 614, 872, 1120 |
| Hpy8I | GTNNAC | 1 cut(s) | 1010 |
| Hpy99I | CGWCG | 2 cut(s) | 72, 117 |
| HpyAV | CCTTC | 6 cut(s) | 32, 230, 441, 464, 570, 1174 |
| HpyCH4III | ACNGT | 2 cut(s) | 97, 1023 |
| HpyCH4IV | ACGT | 2 cut(s) | 67, 808 |
| HpyCH4V | TGCA | 7 cut(s) | 534, 657, 675, 709, 741, 803, 1134 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 98, 299, 384, 531 |
| HpyF3I | CTNAG | 2 cut(s) | 941, 1013 |
| HpySE526I | ACGT | 2 cut(s) | 67, 808 |
| Hsp92I | GRCGYC | 1 cut(s) | 67 |
| Kzo9I | GATC | 1 cut(s) | 982 |
| LmnI | GCTCC | 2 cut(s) | 530, 1079 |
| Lsp1109I | GCAGC | 6 cut(s) | 60, 76, 311, 546, 725, 837 |
| MaeI | CTAG | 3 cut(s) | 614, 923, 957 |
| MaeII | ACGT | 2 cut(s) | 67, 808 |
| MalI | GATC | 1 cut(s) | 984 |
| MboI | GATC | 1 cut(s) | 982 |
| MlsI | TGGCCA | 1 cut(s) | 1113 |
| MluCI | AATT | 7 cut(s) | 245, 281, 482, 621, 834, 857, 918 |
| MluNI | TGGCCA | 1 cut(s) | 1113 |
| Mox20I | TGGCCA | 1 cut(s) | 1113 |
| Mph1103I | ATGCAT | 1 cut(s) | 711 |
| MscI | TGGCCA | 1 cut(s) | 1113 |
| MseI | TTAA | 3 cut(s) | 546, 849, 1186 |
| MslI | CAYNNNNRTG | 1 cut(s) | 465 |
| Msp20I | TGGCCA | 1 cut(s) | 1113 |
| MspA1I | CMGCKG | 1 cut(s) | 89 |
| MspI | CCGG | 1 cut(s) | 362 |
| MspR9I | CCNGG | 5 cut(s) | 55, 362, 416, 571, 1089 |
| Mva1269I | GAATGC | 1 cut(s) | 709 |
| MvaI | CCWGG | 4 cut(s) | 55, 416, 571, 1089 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 98, 299, 384, 531 |
| NciI | CCSGG | 1 cut(s) | 362 |
| NdeI | CATATG | 1 cut(s) | 1136 |
| NdeII | GATC | 1 cut(s) | 982 |
| NmeAIII | GCCGAG | 2 cut(s) | 275, 291 |
| NsiI | ATGCAT | 1 cut(s) | 711 |
| NspI | RCATGY | 2 cut(s) | 479, 705 |
| PagI | TCATGA | 1 cut(s) | 466 |
| PciI | ACATGT | 1 cut(s) | 475 |
| PcsI | WCGNNNNNNNCGW | 2 cut(s) | 11, 255 |
| PctI | GAATGC | 1 cut(s) | 709 |
| PfeI | GAWTC | 5 cut(s) | 9, 146, 200, 392, 617 |
| PflFI | GACNNNGTC | 1 cut(s) | 69 |
| PkrI | GCNGC | 7 cut(s) | 50, 91, 264, 301, 536, 740, 827 |
| PscI | ACATGT | 1 cut(s) | 475 |
| PsiI | TTATAA | 2 cut(s) | 585, 1082 |
| Psp6I | CCWGG | 4 cut(s) | 53, 414, 569, 1087 |
| PspGI | CCWGG | 4 cut(s) | 53, 414, 569, 1087 |
| PspPI | GGNCC | 3 cut(s) | 41, 270, 573 |
| PstI | CTGCAG | 1 cut(s) | 536 |
| PstNI | CAGNNNCTG | 1 cut(s) | 434 |
| PsyI | GACNNNGTC | 1 cut(s) | 69 |
| PvuII | CAGCTG | 1 cut(s) | 89 |
| RsaI | GTAC | 1 cut(s) | 818 |
| RsaNI | GTAC | 1 cut(s) | 817 |
| RseI | CAYNNNNRTG | 1 cut(s) | 465 |
| SaqAI | TTAA | 3 cut(s) | 546, 849, 1186 |
| SatI | GCNGC | 7 cut(s) | 49, 90, 263, 300, 535, 739, 826 |
| Sau3AI | GATC | 1 cut(s) | 982 |
| Sau96I | GGNCC | 3 cut(s) | 41, 270, 573 |
| ScrFI | CCNGG | 5 cut(s) | 55, 362, 416, 571, 1089 |
| SfcI | CTRYAG | 2 cut(s) | 128, 532 |
| SinI | GGWCC | 2 cut(s) | 41, 270 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 465 |
| SmlI | CTYRAG | 2 cut(s) | 303, 1118 |
| SmoI | CTYRAG | 2 cut(s) | 303, 1118 |
| Sse9I | AATT | 7 cut(s) | 245, 281, 482, 621, 834, 857, 918 |
| SsiI | CCGC | 2 cut(s) | 21, 263 |
| SspMI | CTAG | 3 cut(s) | 614, 923, 957 |
| StyD4I | CCNGG | 5 cut(s) | 53, 360, 414, 569, 1087 |
| StyI | CCWWGG | 2 cut(s) | 351, 999 |
| TaaI | ACNGT | 2 cut(s) | 97, 1023 |
| TaiI | ACGT | 2 cut(s) | 70, 811 |
| TaqI | TCGA | 2 cut(s) | 279, 494 |
| TaqII | GACCGA | 1 cut(s) | 58 |
| TasI | AATT | 7 cut(s) | 245, 281, 482, 621, 834, 857, 918 |
| TatI | WGTACW | 1 cut(s) | 816 |
| TauI | GCSGC | 1 cut(s) | 265 |
| TfiI | GAWTC | 5 cut(s) | 9, 146, 200, 392, 617 |
| Tru1I | TTAA | 3 cut(s) | 546, 849, 1186 |
| Tru9I | TTAA | 3 cut(s) | 546, 849, 1186 |
| TseI | GCWGC | 6 cut(s) | 48, 89, 299, 534, 738, 825 |
| TspGWI | ACGGA | 2 cut(s) | 344, 1149 |
| Tth111I | GACNNNGTC | 1 cut(s) | 69 |
| VpaK11BI | GGWCC | 2 cut(s) | 41, 270 |
| XagI | CCTNNNNNAGG | 1 cut(s) | 732 |
| XapI | RAATTY | 3 cut(s) | 245, 857, 918 |
| XbaI | TCTAGA | 1 cut(s) | 613 |
| XceI | RCATGY | 2 cut(s) | 479, 705 |
| XcmI | CCANNNNNNNNNTGG | 1 cut(s) | 280 |
| XspI | CTAG | 3 cut(s) | 614, 923, 957 |
| ZraI | GACGTC | 1 cut(s) | 68 |
| Zsp2I | ATGCAT | 1 cut(s) | 711 |