Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| MTPAP-like_central | PF22600 | 7 - 148 | 2.9e-22 | Poly(A) RNA polymerase, mitochondrial-like, central palm domain |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AarI | CACCTGC | 1 cut(s) | 598 |
| Acc36I | ACCTGC | 1 cut(s) | 598 |
| AciI | CCGC | 1 cut(s) | 1350 |
| AclI | AACGTT | 1 cut(s) | 1108 |
| AclWI | GGATC | 2 cut(s) | 169, 893 |
| AcsI | RAATTY | 3 cut(s) | 323, 722, 816 |
| AcuI | CTGAAG | 2 cut(s) | 428, 984 |
| AfaI | GTAC | 3 cut(s) | 545, 586, 1373 |
| AfiI | CCNNNNNNNGG | 4 cut(s) | 472, 527, 830, 837 |
| AflIII | ACRYGT | 3 cut(s) | 10, 581, 686 |
| AgsI | TTSAA | 9 cut(s) | 119, 210, 538, 647, 680, 896, 927, 1134, 1271 |
| AhlI | ACTAGT | 1 cut(s) | 1027 |
| AjiI | CACGTC | 1 cut(s) | 1172 |
| AjnI | CCWGG | 3 cut(s) | 622, 1160, 1363 |
| AluBI | AGCT | 6 cut(s) | 113, 290, 757, 968, 1001, 1097 |
| AluI | AGCT | 6 cut(s) | 113, 290, 757, 968, 1001, 1097 |
| Alw26I | GTCTC | 3 cut(s) | 189, 289, 1322 |
| AlwI | GGATC | 2 cut(s) | 169, 893 |
| Ama87I | CYCGRG | 1 cut(s) | 527 |
| ApeKI | GCWGC | 2 cut(s) | 981, 1094 |
| ApoI | RAATTY | 3 cut(s) | 323, 722, 816 |
| AspLEI | GCGC | 1 cut(s) | 462 |
| AspS9I | GGNCC | 2 cut(s) | 787, 1302 |
| AsuHPI | GGTGA | 1 cut(s) | 458 |
| AvaI | CYCGRG | 1 cut(s) | 527 |
| AvaII | GGWCC | 2 cut(s) | 787, 1302 |
| AxyI | CCTNAGG | 1 cut(s) | 1179 |
| BaeGI | GKGCMC | 1 cut(s) | 1198 |
| BanII | GRGCYC | 1 cut(s) | 1127 |
| BbsI | GAAGAC | 2 cut(s) | 559, 849 |
| BbvI | GCAGC | 2 cut(s) | 993, 1106 |
| BccI | CCATC | 4 cut(s) | 303, 449, 1257, 1299 |
| BcgI | CGANNNNNNTGC | 2 cut(s) | 1154, 1188 |
| BciT130I | CCWGG | 3 cut(s) | 624, 1162, 1365 |
| BclI | TGATCA | 1 cut(s) | 907 |
| BcoDI | GTCTC | 3 cut(s) | 189, 289, 1322 |
| BcuI | ACTAGT | 1 cut(s) | 1027 |
| BfaI | CTAG | 3 cut(s) | 272, 1028, 1325 |
| BfoI | RGCGCY | 1 cut(s) | 463 |
| BfuAI | ACCTGC | 1 cut(s) | 598 |
| BisI | GCNGC | 2 cut(s) | 982, 1095 |
| BlsI | GCNGC | 2 cut(s) | 983, 1096 |
| Bme1390I | CCNGG | 3 cut(s) | 624, 1162, 1365 |
| Bme18I | GGWCC | 2 cut(s) | 787, 1302 |
| BmeT110I | CYCGRG | 1 cut(s) | 527 |
| BmgBI | CACGTC | 1 cut(s) | 1172 |
| BmgT120I | GGNCC | 2 cut(s) | 787, 1302 |
| BmiI | GGNNCC | 1 cut(s) | 153 |
| BmrFI | CCNGG | 3 cut(s) | 624, 1162, 1365 |
| BmsI | GCATC | 2 cut(s) | 652, 1093 |
| BoxI | GACNNNNGTC | 1 cut(s) | 529 |
| BpiI | GAAGAC | 2 cut(s) | 559, 849 |
| BpuEI | CTTGAG | 2 cut(s) | 673, 794 |
| BsaBI | GATNNNNATC | 1 cut(s) | 618 |
| BsaJI | CCNNGG | 3 cut(s) | 623, 1142, 1160 |
| BsaWI | WCCGGW | 1 cut(s) | 830 |
| Bsc4I | CCNNNNNNNGG | 4 cut(s) | 472, 527, 830, 837 |
| Bse1I | ACTGG | 3 cut(s) | 69, 486, 1075 |
| Bse21I | CCTNAGG | 1 cut(s) | 1179 |
| Bse8I | GATNNNNATC | 1 cut(s) | 618 |
| BseBI | CCWGG | 3 cut(s) | 624, 1162, 1365 |
| BseDI | CCNNGG | 3 cut(s) | 623, 1142, 1160 |
| BseGI | GGATG | 4 cut(s) | 314, 643, 1249, 1291 |
| BseJI | GATNNNNATC | 1 cut(s) | 618 |
| BseLI | CCNNNNNNNGG | 4 cut(s) | 472, 527, 830, 837 |
| BseMII | CTCAG | 4 cut(s) | 77, 1110, 1193, 1349 |
| BseNI | ACTGG | 3 cut(s) | 69, 486, 1075 |
| BseSI | GKGCMC | 1 cut(s) | 1198 |
| BseXI | GCAGC | 2 cut(s) | 993, 1106 |
| BseYI | CCCAGC | 1 cut(s) | 189 |
| BsiHKCI | CYCGRG | 1 cut(s) | 527 |
| BsiSI | CCGG | 1 cut(s) | 831 |
| BsiWI | CGTACG | 1 cut(s) | 543 |
| BslFI | GGGAC | 1 cut(s) | 426 |
| BslI | CCNNNNNNNGG | 4 cut(s) | 472, 527, 830, 837 |
| BsmAI | GTCTC | 3 cut(s) | 189, 289, 1322 |
| BsmFI | GGGAC | 1 cut(s) | 426 |
| BsoBI | CYCGRG | 1 cut(s) | 527 |
| Bsp1286I | GDGCHC | 2 cut(s) | 1127, 1198 |
| Bsp1407I | TGTACA | 1 cut(s) | 584 |
| Bsp143I | GATC | 4 cut(s) | 161, 640, 898, 907 |
| BspACI | CCGC | 1 cut(s) | 1350 |
| BspCNI | CTCAG | 4 cut(s) | 78, 1111, 1192, 1348 |
| BspHI | TCATGA | 2 cut(s) | 97, 1113 |
| BspLI | GGNNCC | 1 cut(s) | 153 |
| BspMI | ACCTGC | 1 cut(s) | 598 |
| BspPI | GGATC | 2 cut(s) | 169, 893 |
| BsrGI | TGTACA | 1 cut(s) | 584 |
| BsrI | ACTGG | 3 cut(s) | 69, 486, 1075 |
| BssECI | CCNNGG | 3 cut(s) | 623, 1142, 1160 |
| BssMI | GATC | 4 cut(s) | 161, 640, 898, 907 |
| BssT1I | CCWWGG | 1 cut(s) | 1142 |
| Bst2UI | CCWGG | 3 cut(s) | 624, 1162, 1365 |
| Bst4CI | ACNGT | 3 cut(s) | 148, 837, 1049 |
| Bst6I | CTCTTC | 1 cut(s) | 928 |
| BstAUI | TGTACA | 1 cut(s) | 584 |
| BstC8I | GCNNGC | 2 cut(s) | 187, 1348 |
| BstDEI | CTNAG | 5 cut(s) | 86, 608, 1119, 1179, 1335 |
| BstF5I | GGATG | 4 cut(s) | 314, 643, 1249, 1291 |
| BstH2I | RGCGCY | 1 cut(s) | 463 |
| BstHHI | GCGC | 1 cut(s) | 462 |
| BstKTI | GATC | 4 cut(s) | 164, 643, 901, 910 |
| BstMAI | GTCTC | 3 cut(s) | 189, 289, 1322 |
| BstMBI | GATC | 4 cut(s) | 161, 640, 898, 907 |
| BstNI | CCWGG | 3 cut(s) | 624, 1162, 1365 |
| BstNSI | RCATGY | 4 cut(s) | 14, 585, 690, 1350 |
| BstPAI | GACNNNNGTC | 1 cut(s) | 529 |
| BstSCI | CCNGG | 3 cut(s) | 622, 1160, 1363 |
| BstSLI | GKGCMC | 1 cut(s) | 1198 |
| BstV1I | GCAGC | 2 cut(s) | 993, 1106 |
| BstV2I | GAAGAC | 2 cut(s) | 559, 849 |
| BstX2I | RGATCY | 1 cut(s) | 898 |
| BstYI | RGATCY | 1 cut(s) | 898 |
| Bsu36I | CCTNAGG | 1 cut(s) | 1179 |
| BtgZI | GCGATG | 1 cut(s) | 1070 |
| BtrI | CACGTC | 1 cut(s) | 1172 |
| BtsCI | GGATG | 4 cut(s) | 314, 643, 1249, 1291 |
| BtsI | GCAGTG | 1 cut(s) | 333 |
| BtsIMutI | CAGTG | 3 cut(s) | 62, 333, 842 |
| BveI | ACCTGC | 1 cut(s) | 598 |
| Cac8I | GCNNGC | 2 cut(s) | 187, 1348 |
| CciI | TCATGA | 2 cut(s) | 97, 1113 |
| CfoI | GCGC | 1 cut(s) | 462 |
| Cfr13I | GGNCC | 2 cut(s) | 787, 1302 |
| Csp6I | GTAC | 3 cut(s) | 544, 585, 1372 |
| CviQI | GTAC | 3 cut(s) | 544, 585, 1372 |
| DdeI | CTNAG | 5 cut(s) | 86, 608, 1119, 1179, 1335 |
| DpnI | GATC | 4 cut(s) | 163, 642, 900, 909 |
| DpnII | GATC | 4 cut(s) | 161, 640, 898, 907 |
| DraI | TTTAAA | 1 cut(s) | 322 |
| Eam1104I | CTCTTC | 1 cut(s) | 928 |
| EarI | CTCTTC | 1 cut(s) | 928 |
| Eco130I | CCWWGG | 1 cut(s) | 1142 |
| Eco24I | GRGCYC | 1 cut(s) | 1127 |
| Eco32I | GATATC | 1 cut(s) | 960 |
| Eco47I | GGWCC | 2 cut(s) | 787, 1302 |
| Eco57I | CTGAAG | 2 cut(s) | 428, 984 |
| Eco81I | CCTNAGG | 1 cut(s) | 1179 |
| Eco88I | CYCGRG | 1 cut(s) | 527 |
| EcoRII | CCWGG | 3 cut(s) | 622, 1160, 1363 |
| EcoRV | GATATC | 1 cut(s) | 960 |
| EcoT14I | CCWWGG | 1 cut(s) | 1142 |
| EcoT38I | GRGCYC | 1 cut(s) | 1127 |
| ErhI | CCWWGG | 1 cut(s) | 1142 |
| FaqI | GGGAC | 1 cut(s) | 426 |
| FbaI | TGATCA | 1 cut(s) | 907 |
| Fnu4HI | GCNGC | 2 cut(s) | 982, 1095 |
| FokI | GGATG | 4 cut(s) | 321, 650, 1236, 1278 |
| FriOI | GRGCYC | 1 cut(s) | 1127 |
| Fsp4HI | GCNGC | 2 cut(s) | 982, 1095 |
| FspBI | CTAG | 3 cut(s) | 272, 1028, 1325 |
| GlaI | GCGC | 1 cut(s) | 461 |
| GluI | GCNGC | 2 cut(s) | 982, 1095 |
| GsaI | CCCAGC | 1 cut(s) | 193 |
| HaeII | RGCGCY | 1 cut(s) | 463 |
| HapII | CCGG | 1 cut(s) | 831 |
| HhaI | GCGC | 1 cut(s) | 462 |
| Hin6I | GCGC | 1 cut(s) | 460 |
| HinP1I | GCGC | 1 cut(s) | 460 |
| HindIII | AAGCTT | 1 cut(s) | 966 |
| HinfI | GANTC | 5 cut(s) | 40, 90, 119, 525, 628 |
| HpaII | CCGG | 1 cut(s) | 831 |
| HphI | GGTGA | 1 cut(s) | 458 |
| Hpy166II | GTNNAC | 2 cut(s) | 587, 1305 |
| Hpy188III | TCNNGA | 6 cut(s) | 98, 1114, 1134, 1271, 1325, 1337 |
| Hpy8I | GTNNAC | 2 cut(s) | 587, 1305 |
| Hpy99I | CGWCG | 1 cut(s) | 1176 |
| HpyAV | CCTTC | 2 cut(s) | 104, 403 |
| HpyCH4III | ACNGT | 3 cut(s) | 148, 837, 1049 |
| HpyCH4IV | ACGT | 4 cut(s) | 673, 699, 1108, 1171 |
| HpyCH4V | TGCA | 7 cut(s) | 143, 338, 593, 665, 1094, 1186, 1346 |
| HpyF3I | CTNAG | 5 cut(s) | 86, 608, 1119, 1179, 1335 |
| HpySE526I | ACGT | 4 cut(s) | 673, 699, 1108, 1171 |
| HspAI | GCGC | 1 cut(s) | 460 |
| Ksp22I | TGATCA | 1 cut(s) | 907 |
| Kzo9I | GATC | 4 cut(s) | 161, 640, 898, 907 |
| LmnI | GCTCC | 3 cut(s) | 110, 151, 728 |
| Lsp1109I | GCAGC | 2 cut(s) | 993, 1106 |
| LweI | GCATC | 2 cut(s) | 652, 1093 |
| MaeI | CTAG | 3 cut(s) | 272, 1028, 1325 |
| MaeII | ACGT | 4 cut(s) | 673, 699, 1108, 1171 |
| MaeIII | GTNAC | 5 cut(s) | 102, 700, 750, 1010, 1054 |
| MalI | GATC | 4 cut(s) | 163, 642, 900, 909 |
| MboI | GATC | 4 cut(s) | 161, 640, 898, 907 |
| MboII | GAAGA | 8 cut(s) | 80, 559, 635, 692, 854, 908, 915, 1243 |
| MfeI | CAATTG | 1 cut(s) | 210 |
| MflI | RGATCY | 1 cut(s) | 898 |
| MhlI | GDGCHC | 2 cut(s) | 1127, 1198 |
| MluCI | AATT | 9 cut(s) | 210, 266, 323, 594, 722, 816, 947, 1150, 1223 |
| MlyI | GAGTC | 1 cut(s) | 519 |
| MmeI | TCCRAC | 2 cut(s) | 696, 1057 |
| MseI | TTAA | 6 cut(s) | 54, 134, 321, 353, 711, 972 |
| MslI | CAYNNNNRTG | 2 cut(s) | 992, 1089 |
| MspI | CCGG | 1 cut(s) | 831 |
| MspR9I | CCNGG | 3 cut(s) | 624, 1162, 1365 |
| MunI | CAATTG | 1 cut(s) | 210 |
| MvaI | CCWGG | 3 cut(s) | 624, 1162, 1365 |
| NdeII | GATC | 4 cut(s) | 161, 640, 898, 907 |
| NlaIV | GGNNCC | 1 cut(s) | 153 |
| NmuCI | GTSAC | 3 cut(s) | 750, 1010, 1054 |
| NspI | RCATGY | 4 cut(s) | 14, 585, 690, 1350 |
| PaeI | GCATGC | 1 cut(s) | 1350 |
| PagI | TCATGA | 2 cut(s) | 97, 1113 |
| PaqCI | CACCTGC | 1 cut(s) | 598 |
| PciI | ACATGT | 3 cut(s) | 10, 581, 686 |
| PfeI | GAWTC | 4 cut(s) | 40, 90, 119, 628 |
| Pfl23II | CGTACG | 1 cut(s) | 543 |
| PkrI | GCNGC | 2 cut(s) | 983, 1096 |
| PleI | GAGTC | 1 cut(s) | 519 |
| PpsI | GAGTC | 1 cut(s) | 519 |
| PscI | ACATGT | 3 cut(s) | 10, 581, 686 |
| PshAI | GACNNNNGTC | 1 cut(s) | 529 |
| Psp1406I | AACGTT | 1 cut(s) | 1108 |
| Psp6I | CCWGG | 3 cut(s) | 622, 1160, 1363 |
| PspFI | CCCAGC | 1 cut(s) | 189 |
| PspGI | CCWGG | 3 cut(s) | 622, 1160, 1363 |
| PspLI | CGTACG | 1 cut(s) | 543 |
| PspN4I | GGNNCC | 1 cut(s) | 153 |
| PspPI | GGNCC | 2 cut(s) | 787, 1302 |
| PsuI | RGATCY | 1 cut(s) | 898 |
| RsaI | GTAC | 3 cut(s) | 545, 586, 1373 |
| RsaNI | GTAC | 3 cut(s) | 544, 585, 1372 |
| RseI | CAYNNNNRTG | 2 cut(s) | 992, 1089 |
| SaqAI | TTAA | 6 cut(s) | 54, 134, 321, 353, 711, 972 |
| SatI | GCNGC | 2 cut(s) | 982, 1095 |
| Sau3AI | GATC | 4 cut(s) | 161, 640, 898, 907 |
| Sau96I | GGNCC | 2 cut(s) | 787, 1302 |
| SchI | GAGTC | 1 cut(s) | 519 |
| ScrFI | CCNGG | 3 cut(s) | 624, 1162, 1365 |
| SduI | GDGCHC | 2 cut(s) | 1127, 1198 |
| SfaNI | GCATC | 2 cut(s) | 652, 1093 |
| SinI | GGWCC | 2 cut(s) | 787, 1302 |
| SmiMI | CAYNNNNRTG | 2 cut(s) | 992, 1089 |
| SmlI | CTYRAG | 2 cut(s) | 652, 773 |
| SmoI | CTYRAG | 2 cut(s) | 652, 773 |
| SpeI | ACTAGT | 1 cut(s) | 1027 |
| SphI | GCATGC | 1 cut(s) | 1350 |
| Sse9I | AATT | 9 cut(s) | 210, 266, 323, 594, 722, 816, 947, 1150, 1223 |
| SsiI | CCGC | 1 cut(s) | 1350 |
| SspMI | CTAG | 3 cut(s) | 272, 1028, 1325 |
| StyD4I | CCNGG | 3 cut(s) | 622, 1160, 1363 |
| StyI | CCWWGG | 1 cut(s) | 1142 |
| TaaI | ACNGT | 3 cut(s) | 148, 837, 1049 |
| TaiI | ACGT | 4 cut(s) | 676, 702, 1111, 1174 |
| TaqI | TCGA | 1 cut(s) | 360 |
| TasI | AATT | 9 cut(s) | 210, 266, 323, 594, 722, 816, 947, 1150, 1223 |
| TatI | WGTACW | 2 cut(s) | 584, 1371 |
| TfiI | GAWTC | 4 cut(s) | 40, 90, 119, 628 |
| Tru1I | TTAA | 6 cut(s) | 54, 134, 321, 353, 711, 972 |
| Tru9I | TTAA | 6 cut(s) | 54, 134, 321, 353, 711, 972 |
| TscAI | CASTG | 3 cut(s) | 69, 340, 842 |
| TseFI | GTSAC | 3 cut(s) | 750, 1010, 1054 |
| TseI | GCWGC | 2 cut(s) | 981, 1094 |
| Tsp45I | GTSAC | 3 cut(s) | 750, 1010, 1054 |
| TspGWI | ACGGA | 1 cut(s) | 650 |
| TspRI | CASTG | 3 cut(s) | 69, 340, 842 |
| VpaK11BI | GGWCC | 2 cut(s) | 787, 1302 |
| XapI | RAATTY | 3 cut(s) | 323, 722, 816 |
| XbaI | TCTAGA | 1 cut(s) | 1324 |
| XceI | RCATGY | 4 cut(s) | 14, 585, 690, 1350 |
| XspI | CTAG | 3 cut(s) | 272, 1028, 1325 |