Basic Information

Type: gene

Biological Identity

Species

arabidopsis_thaliana

Chromosome

Orthogroup ID

OG0000151

Physical Location & Seq

Genomic Coordinates Reverse (-)

15123089 .. 15124435

Gene Structure 1347 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

AT5G37970.1

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1089 bp

ATGCCAACATTTCCTCAATCGTTTCCAATGAACGGTGGTGATGGTCCGCACAGTTACATCCACAATTCTTCCTATCAAAAAGTGGCGATCGATGGCGTTAAAGAAAGGACAAGCGAAGCGATCTTAGAAAAACTCGATCTTGAATTCCTCAACCGTAACTCTGAAGAAAATATCTTGAGAATTGTGGATTTTGGTTGTTCCATTGGACCTAACACGTTTGATGTTGTCCAAAATATCATTGATACAGTGAAACAAAAACGCCTAAAAGAAAACAAAACCTATATTGGTGCTCCTCTTGAGTTCCAAGTATGCTTCAATGATCAACCAAACAATGATTTTAACACACTTTTTCGAACCCAACCGTTCTTTTCCCGGAAAGAATATTTTTCCGTGGGAGTTCCAGGCTCCTTCCATGGTAGAGTATTACCAAAAAATAGCCTCCATATAGGTCACACTTCCTATACACTCCACTGGCTTTCTAATGTTCCCCAACATGTTTGTGACAAGAAATCTCCGGCATTGAATAAAAGCTATATTCAATGTAATAATTTAGTAGATGAAGTGACCAAGGCTTACAAGATCCAGTTCAGAAAAGATTTTGGAGGATTTCTTGAGGCAAGGGCGGAAGAGCTTGTCTCGGGCGGATTGATGATCCTTTCAGGACAATGCTTGCCCGATGGTATCCCAAAGGCTTTGACATGGCAAGGTGTTGTGATCGATATGATTGGAGATTGTCTTATGGATCTGGCTAAATTGGGAATAACAAGCAAGGAAAAGATCGAACTGTTCAGTTTACCCACATACATTCCGCATATTAGTGAATTCAAGGCAAACATTGAACAAAATGAAAACTTTAATGTCGAGACAATGGAGGAGATAAGTCATCCTATGGATTATATGCCATTAACCAACGACTTCATCACTTCCATGTTTCGAGCCATTCTCAATACAATTATCGAAGAACACTTTGGAGAAGGTGTGGTCAACGAGCTATTCAGTCGACTTGCTAAAAGGCTCGACAAGTACCCAATTGATTTCAAAAGGTGTAAAAAGTATGTGAACTATTTTATCGTGCTTAAGAGAAAGTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0001101 GO:0002238 GO:0003674 GO:0003824 GO:0006950 GO:0006952 GO:0008150 GO:0008152 GO:0008168 GO:0008171 GO:0008757 GO:0009314 GO:0009416 GO:0009605 GO:0009607 GO:0009611 GO:0009617 GO:0009620 GO:0009628 GO:0009719 GO:0009725 GO:0009751 GO:0009753 GO:0009892 GO:0009987 GO:0010029 GO:0010033 GO:0010468 GO:0010605 GO:0010608 GO:0010629 GO:0014070 GO:0016441 GO:0016458 GO:0016740 GO:0016741 GO:0019010 GO:0019222 GO:0031047 GO:0032259 GO:0035194 GO:0035195 GO:0040029 GO:0042221 GO:0042493 GO:0042742 GO:0043207 GO:0046677 GO:0048519 GO:0048580 GO:0050789 GO:0050793 GO:0050896 GO:0051239 GO:0051704 GO:0051707 GO:0060255 GO:0065007 GO:0080027 GO:0098542 GO:1900140 GO:1901700 GO:2000026 GO:2000280

KEGG Pathways

Metabolic & Signaling

ko03040 map03040

Pfam Domains

Protein Families

Methyltransf_7

Protein Analysis

362

Amino Acids

41.41

Weight (kDa)

6.38

Isoelectric Point (pI)

42.13

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
Methyltransf_7	PF03492	52 - 361	1.1e-99	SAM dependent carboxyl methyltransferase

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

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Publication-ready

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Orthologous Genes (Group: OG0000151)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT5G37970 AT5G37990 AT5G38100 AT5G38100 AT5G38100 AT5G38100 AT5G38780 AT5G38780
fragaria_vesca	FvH4_4g07940 FvH4_4g07950 FvH4_5g16970 FvH4_7g18490
malus_domestica	MD02G1312100.v1.1 MD02G1312500.v1.1 MD05G1007900.v1.1 MD06G1223300.v1.1 MD06G1223500.v1.1 MD06G1223600.v1.1 MD06G1223700.v1.1 MD06G1223800.v1.1 MD06G1227300.v1.1 MD09G1253900.v1.1 MD09G1254000.v1.1 MD09G1254100.v1.1 MD09G1254200.v1.1 MD09G1254300.v1.1 MD10G1005200.v1.1 MD10G1005900.v1.1 MD14G1232400.v1.1 MD14G1232700.v1.1 MD14G1232800.v1.1 MD14G1232900.v1.1 MD14G1233000.v1.1 MD15G1255300.v1.1
prunus_persica	Prupe.5G228400_v2.0.a1 Prupe.5G228500_v2.0.a1 Prupe.5G228500_v2.0.a1 Prupe.5G228500_v2.0.a1 Prupe.5G228600_v2.0.a1 Prupe.5G228700_v2.0.a1 Prupe.5G228800_v2.0.a1 Prupe.5G228900_v2.0.a1 Prupe.5G229000_v2.0.a1 Prupe.8G008300_v2.0.a1
pyrus_communis	pycom02g26200 pycom02g26220 pycom05g00410 pycom06g19910 pycom06g19920 pycom06g19930 pycom06g19940 pycom06g20380 pycom09g16970 pycom09g16990 pycom09g17000 pycom10g00420 pycom14g19370 pycom14g19380 pycom14g19420 pycom14g19430 pycom15g22380 pycom15g22390
rosa_chinensis	RchiOBHm_Chr1g0327241 RchiOBHm_Chr1g0327261 RchiOBHm_Chr2g0128631 RchiOBHm_Chr2g0137031 RchiOBHm_Chr3g0486031 RchiOBHm_Chr3g0486051 RchiOBHm_Chr3g0486091 RchiOBHm_Chr4g0400921 RchiOBHm_Chr4g0400971 RchiOBHm_Chr4g0400991 RchiOBHm_Chr7g0178281 RchiOBHm_Chr7g0178301 RchiOBHm_Chr7g0178321 RchiOBHm_Chr7g0178951 RchiOBHm_Chr7g0178961 RchiOBHm_Chr7g0178971 RchiOBHm_Chr7g0178991 RchiOBHm_Chr7g0179001 RchiOBHm_Chr7g0179021 RchiOBHm_Chr7g0179031 RchiOBHm_Chr7g0179041 RchiOBHm_Chr7g0179051 RchiOBHm_Chr7g0187641 RchiOBHm_Chr7g0201881 RchiOBHm_Chr7g0201901
rosa_laevigata	RLG00000005390 RLG00000005391 RLG00000005392 RLG00000005394 RLG00000005456 RLG00000009163 RLG00000009164 RLG00000019598 RLG00000023105 RLG00000030028
rosa_multiflora	Rmu_co8337425.1_g000001 Rmu_sc0000795.1_g000125 Rmu_sc0000837.1_g000085 Rmu_sc0000888.1_g000008 Rmu_sc0000888.1_g000010 Rmu_sc0000888.1_g000011 Rmu_sc0000888.1_g000013 Rmu_sc0001021.1_g000003 Rmu_sc0001021.1_g000004 Rmu_sc0001021.1_g000006 Rmu_sc0001374.1_g000046 Rmu_sc0002026.1_g000007 Rmu_sc0002026.1_g000019 Rmu_sc0003465.1_g000046 Rmu_sc0004483.1_g000006 Rmu_sc0006229.1_g000002 Rmu_sc0006736.1_g000019 Rmu_sc0006736.1_g000027 Rmu_sc0007073.1_g000003 Rmu_sc0036373.1_g000001 Rmu_ssc0000009.1_g000007
rosa_roxburghii	Rroxscaffold_2G00107760 Rroxscaffold_2G00115440 Rroxscaffold_2G00115920 Rroxscaffold_3G00255030 Rroxscaffold_3G00267200 Rroxscaffold_3G00274440 Rroxscaffold_3G00274450 Rroxscaffold_3G00274480 Rroxscaffold_4G00322940 Rroxscaffold_4G00322950 Rroxscaffold_4G00322980 Rroxscaffold_4G00323000 Rroxscaffold_4G00323020 Rroxscaffold_5G00345860 Rroxscaffold_5G00345890 Rroxscaffold_5G00345920 Rroxscaffold_6G00396060 Rroxscaffold_6G00396070
rosa_rugosa	Rorug01G0064700 Rorug01G0064700 Rorug01G0064700 Rorug01G0064700 Rorug01G0064800 Rorug01G0297000 Rorug02G0279500 Rorug02G0337300 Rorug03G0223300 Rorug03G0223400 Rorug03G0223400 Rorug03G0223400 Rorug03G0223400 Rorug03G0223500 Rorug03G0223600 Rorug04G0027400 Rorug04G0027500 Rorug04G0027600 Rorug06G0420600 Rorug06G0420600 Rorug06G0483400 Rorug07G0066400 Rorug07G0066600
rosa_samantha	Rh1AG081900 Rh1AG082300 Rh1AG082400 Rh1AG305600 Rh2BG340800 Rh2BG393000 Rh3BG308300 Rh4CG113300 Rh4CG113700 Rh7CG020600 Rh7CG020700 Rh7CG020800 Rh7CG021000 Rh7CG088900 Rh7CG204900
rosa_wichuraiana	Rw0G002670 Rw0G014940 Rw0G021450 Rw1G006470 Rw1G006490 Rw2G026880 Rw2G027140 Rw2G031610 Rw3G024210 Rw3G024220 Rw7G001620 Rw7G001630 Rw7G001640 Rw7G001650 Rw7G016930 Rw7G016950

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AccI	GTMKAC	1 cut(s)	1000
AciI	CCGC	4 cut(s)	47, 623, 642, 809
AclWI	GGATC	3 cut(s)	574, 646, 750
AcsI	RAATTY	2 cut(s)	143, 821
AcuI	CTGAAG	1 cut(s)	183
AfaI	GTAC	1 cut(s)	1025
AfiI	CCNNNNNNNGG	1 cut(s)	32
AflII	CTTAAG	1 cut(s)	1076
AflIII	ACRYGT	2 cut(s)	213, 493
AgsI	TTSAA	7 cut(s)	143, 316, 523, 539, 826, 839, 1039
AjnI	CCWGG	1 cut(s)	400
AjuI	GAANNNNNNNTTGG	2 cut(s)	951, 983
AluBI	AGCT	3 cut(s)	531, 631, 991
AluI	AGCT	3 cut(s)	531, 631, 991
Alw21I	GWGCWC	1 cut(s)	292
Alw26I	GTCTC	2 cut(s)	640, 857
AlwI	GGATC	3 cut(s)	574, 646, 750
Ama87I	CYCGRG	1 cut(s)	637
ApoI	RAATTY	2 cut(s)	143, 821
AspS9I	GGNCC	2 cut(s)	44, 206
AsuC2I	CCSGG	1 cut(s)	373
AsuHPI	GGTGA	1 cut(s)	50
AsuII	TTCGAA	1 cut(s)	352
AvaI	CYCGRG	1 cut(s)	637
AvaII	GGWCC	2 cut(s)	44, 206
Bbv12I	GWGCWC	1 cut(s)	292
BccI	CCATC	3 cut(s)	35, 86, 671
BciT130I	CCWGG	1 cut(s)	402
BciVI	GTATCC	1 cut(s)	692
BclI	TGATCA	1 cut(s)	319
BcnI	CCSGG	1 cut(s)	373
BcoDI	GTCTC	2 cut(s)	640, 857
BfrI	CTTAAG	1 cut(s)	1076
BfuI	GTATCC	1 cut(s)	692
Bme1390I	CCNGG	2 cut(s)	373, 402
Bme18I	GGWCC	2 cut(s)	44, 206
BmeT110I	CYCGRG	1 cut(s)	637
BmgT120I	GGNCC	2 cut(s)	44, 206
BmiI	GGNNCC	1 cut(s)	406
BmrFI	CCNGG	2 cut(s)	373, 402
BplI	GAGNNNNNCTC	4 cut(s)	620, 652, 927, 959
Bpu14I	TTCGAA	1 cut(s)	352
BpuEI	CTTGAG	3 cut(s)	196, 317, 632
BpuMI	CCSGG	1 cut(s)	373
Bsa29I	ATCGAT	2 cut(s)	90, 717
BsaJI	CCNNGG	3 cut(s)	390, 412, 567
BsaXI	ACNNNNNCTCC	2 cut(s)	963, 993
Bsc4I	CCNNNNNNNGG	1 cut(s)	32
Bse1I	ACTGG	2 cut(s)	476, 583
BseBI	CCWGG	1 cut(s)	402
BseCI	ATCGAT	2 cut(s)	90, 717
BseDI	CCNNGG	3 cut(s)	390, 412, 567
BseGI	GGATG	2 cut(s)	57, 883
BseLI	CCNNNNNNNGG	1 cut(s)	32
BseNI	ACTGG	2 cut(s)	476, 583
BseRI	GAGGAG	2 cut(s)	282, 887
Bsh1285I	CGRYCG	1 cut(s)	90
BshVI	ATCGAT	2 cut(s)	90, 717
BsiEI	CGRYCG	1 cut(s)	90
BsiHKAI	GWGCWC	1 cut(s)	292
BsiHKCI	CYCGRG	1 cut(s)	637
BsiSI	CCGG	2 cut(s)	373, 515
BslI	CCNNNNNNNGG	1 cut(s)	32
BsmAI	GTCTC	2 cut(s)	640, 857
BsoBI	CYCGRG	1 cut(s)	637
Bsp119I	TTCGAA	1 cut(s)	352
Bsp1286I	GDGCHC	1 cut(s)	292
Bsp143I	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
Bsp19I	CCATGG	1 cut(s)	412
BspACI	CCGC	4 cut(s)	47, 623, 642, 809
BspDI	ATCGAT	2 cut(s)	90, 717
BspLI	GGNNCC	1 cut(s)	406
BspPI	GGATC	3 cut(s)	574, 646, 750
BspQI	GCTCTTC	1 cut(s)	621
BspT104I	TTCGAA	1 cut(s)	352
BspTI	CTTAAG	1 cut(s)	1076
BsrI	ACTGG	2 cut(s)	476, 583
BssECI	CCNNGG	3 cut(s)	390, 412, 567
BssMI	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
BssT1I	CCWWGG	2 cut(s)	412, 567
Bst2UI	CCWGG	1 cut(s)	402
Bst4CI	ACNGT	6 cut(s)	35, 53, 155, 247, 363, 786
Bst6I	CTCTTC	1 cut(s)	621
BstAFI	CTTAAG	1 cut(s)	1076
BstBI	TTCGAA	1 cut(s)	352
BstC8I	GCNNGC	1 cut(s)	671
BstDEI	CTNAG	1 cut(s)	124
BstDSI	CCRYGG	2 cut(s)	390, 412
BstF5I	GGATG	2 cut(s)	57, 883
BstKTI	GATC	9 cut(s)	90, 123, 139, 322, 582, 654, 717, 745, 780
BstMAI	GTCTC	2 cut(s)	640, 857
BstMBI	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
BstMCI	CGRYCG	1 cut(s)	90
BstNI	CCWGG	1 cut(s)	402
BstNSI	RCATGY	1 cut(s)	497
BstSCI	CCNGG	2 cut(s)	371, 400
BstX2I	RGATCY	2 cut(s)	579, 742
BstYI	RGATCY	2 cut(s)	579, 742
Bsu15I	ATCGAT	2 cut(s)	90, 717
BsuI	GTATCC	1 cut(s)	692
BsuTUI	ATCGAT	2 cut(s)	90, 717
BtgI	CCRYGG	2 cut(s)	390, 412
BtsCI	GGATG	2 cut(s)	57, 883
BtsIMutI	CAGTG	2 cut(s)	252, 469
Cac8I	GCNNGC	1 cut(s)	671
Cfr13I	GGNCC	2 cut(s)	44, 206
ClaI	ATCGAT	2 cut(s)	90, 717
Csp6I	GTAC	1 cut(s)	1024
CviAII	CATG	4 cut(s)	413, 494, 699, 928
CviQI	GTAC	1 cut(s)	1024
DdeI	CTNAG	1 cut(s)	124
DpnI	GATC	9 cut(s)	89, 122, 138, 321, 581, 653, 716, 744, 779
DpnII	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
Eam1104I	CTCTTC	1 cut(s)	621
EarI	CTCTTC	1 cut(s)	621
EciI	GGCGGA	2 cut(s)	638, 657
Eco130I	CCWWGG	2 cut(s)	412, 567
Eco47I	GGWCC	2 cut(s)	44, 206
Eco57I	CTGAAG	1 cut(s)	183
Eco88I	CYCGRG	1 cut(s)	637
EcoRI	GAATTC	2 cut(s)	143, 821
EcoRII	CCWGG	1 cut(s)	400
EcoT14I	CCWWGG	2 cut(s)	412, 567
ErhI	CCWWGG	2 cut(s)	412, 567
FaeI	CATG	4 cut(s)	416, 497, 702, 931
FatI	CATG	4 cut(s)	412, 493, 698, 927
FbaI	TGATCA	1 cut(s)	319
FblI	GTMKAC	1 cut(s)	1000
FokI	GGATG	2 cut(s)	44, 870
HapII	CCGG	2 cut(s)	373, 515
Hin1II	CATG	4 cut(s)	416, 497, 702, 931
HincII	GTYRAC	2 cut(s)	985, 1001
HindII	GTYRAC	2 cut(s)	985, 1001
HpaII	CCGG	2 cut(s)	373, 515
HphI	GGTGA	1 cut(s)	50
Hpy166II	GTNNAC	4 cut(s)	794, 985, 1001, 1060
Hpy188I	TCNGA	2 cut(s)	163, 590
Hpy188III	TCNNGA	6 cut(s)	140, 175, 296, 611, 660, 862
Hpy8I	GTNNAC	4 cut(s)	794, 985, 1001, 1060
HpyAV	CCTTC	2 cut(s)	418, 968
HpyCH4III	ACNGT	6 cut(s)	35, 53, 155, 247, 363, 786
HpyCH4IV	ACGT	1 cut(s)	215
HpyF3I	CTNAG	1 cut(s)	124
HpySE526I	ACGT	1 cut(s)	215
Hsp92II	CATG	4 cut(s)	416, 497, 702, 931
Ksp22I	TGATCA	1 cut(s)	319
Kzo9I	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
LguI	GCTCTTC	1 cut(s)	621
LmnI	GCTCC	2 cut(s)	295, 410
LpnPI	CCDG	8 cut(s)	386, 387, 414, 457, 528, 596, 645, 731
MaeII	ACGT	1 cut(s)	215
MaeIII	GTNAC	5 cut(s)	53, 155, 449, 500, 562
MalI	GATC	9 cut(s)	89, 122, 138, 321, 581, 653, 716, 744, 779
MboI	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
MboII	GAAGA	4 cut(s)	60, 176, 638, 971
MfeI	CAATTG	1 cut(s)	1029
MflI	RGATCY	2 cut(s)	579, 742
MhlI	GDGCHC	1 cut(s)	292
MluCI	AATT	8 cut(s)	64, 143, 180, 547, 752, 821, 951, 1029
MnlI	CCTC	7 cut(s)	24, 158, 303, 449, 596, 607, 865
MseI	TTAA	5 cut(s)	99, 339, 855, 905, 1077
MslI	CAYNNNNRTG	3 cut(s)	498, 816, 926
MspCI	CTTAAG	1 cut(s)	1076
MspI	CCGG	2 cut(s)	373, 515
MspR9I	CCNGG	2 cut(s)	373, 402
MunI	CAATTG	1 cut(s)	1029
MvaI	CCWGG	1 cut(s)	402
NciI	CCSGG	1 cut(s)	373
NcoI	CCATGG	1 cut(s)	412
NdeII	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
NlaIII	CATG	4 cut(s)	416, 497, 702, 931
NlaIV	GGNNCC	1 cut(s)	406
NmuCI	GTSAC	3 cut(s)	449, 500, 562
NspI	RCATGY	1 cut(s)	497
NspV	TTCGAA	1 cut(s)	352
PciI	ACATGT	1 cut(s)	493
PciSI	GCTCTTC	1 cut(s)	621
PfoI	TCCNGGA	1 cut(s)	371
Ple19I	CGATCG	1 cut(s)	90
PscI	ACATGT	1 cut(s)	493
Psp6I	CCWGG	1 cut(s)	400
PspGI	CCWGG	1 cut(s)	400
PspN4I	GGNNCC	1 cut(s)	406
PspPI	GGNCC	2 cut(s)	44, 206
PsuI	RGATCY	2 cut(s)	579, 742
PvuI	CGATCG	1 cut(s)	90
RsaI	GTAC	1 cut(s)	1025
RsaNI	GTAC	1 cut(s)	1024
RseI	CAYNNNNRTG	3 cut(s)	498, 816, 926
SalI	GTCGAC	1 cut(s)	999
SapI	GCTCTTC	1 cut(s)	621
SaqAI	TTAA	5 cut(s)	99, 339, 855, 905, 1077
Sau3AI	GATC	9 cut(s)	87, 120, 136, 319, 579, 651, 714, 742, 777
Sau96I	GGNCC	2 cut(s)	44, 206
ScrFI	CCNGG	2 cut(s)	373, 402
SduI	GDGCHC	1 cut(s)	292
SfuI	TTCGAA	1 cut(s)	352
SinI	GGWCC	2 cut(s)	44, 206
SmiMI	CAYNNNNRTG	3 cut(s)	498, 816, 926
SmlI	CTYRAG	4 cut(s)	175, 296, 611, 1076
SmoI	CTYRAG	4 cut(s)	175, 296, 611, 1076
Sse9I	AATT	8 cut(s)	64, 143, 180, 547, 752, 821, 951, 1029
SsiI	CCGC	4 cut(s)	47, 623, 642, 809
SspI	AATATT	1 cut(s)	383
StyD4I	CCNGG	2 cut(s)	371, 400
StyI	CCWWGG	2 cut(s)	412, 567
TaaI	ACNGT	6 cut(s)	35, 53, 155, 247, 363, 786
TaiI	ACGT	1 cut(s)	218
TasI	AATT	8 cut(s)	64, 143, 180, 547, 752, 821, 951, 1029
Tru1I	TTAA	5 cut(s)	99, 339, 855, 905, 1077
Tru9I	TTAA	5 cut(s)	99, 339, 855, 905, 1077
TscAI	CASTG	2 cut(s)	252, 476
TseFI	GTSAC	3 cut(s)	449, 500, 562
Tsp45I	GTSAC	3 cut(s)	449, 500, 562
TspDTI	ATGAA	4 cut(s)	44, 573, 861, 907
TspGWI	ACGGA	1 cut(s)	379
TspRI	CASTG	2 cut(s)	252, 476
Vha464I	CTTAAG	1 cut(s)	1076
VpaK11BI	GGWCC	2 cut(s)	44, 206
XapI	RAATTY	2 cut(s)	143, 821
XceI	RCATGY	1 cut(s)	497
XmiI	GTMKAC	1 cut(s)	1000

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.