divergent subfamily of APPLE domains
Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AarI | CACCTGC | 1 cut(s) | 113 |
| AasI | GACNNNNNNGTC | 1 cut(s) | 970 |
| Acc36I | ACCTGC | 1 cut(s) | 113 |
| AccIII | TCCGGA | 1 cut(s) | 2234 |
| AciI | CCGC | 2 cut(s) | 342, 683 |
| AclWI | GGATC | 2 cut(s) | 530, 1259 |
| AcsI | RAATTY | 6 cut(s) | 484, 1144, 1211, 1311, 1609, 1719 |
| AcuI | CTGAAG | 2 cut(s) | 1649, 2307 |
| AfaI | GTAC | 8 cut(s) | 191, 728, 916, 936, 1034, 1556, 1987, 2085 |
| AfiI | CCNNNNNNNGG | 1 cut(s) | 545 |
| AgeI | ACCGGT | 1 cut(s) | 741 |
| AgsI | TTSAA | 6 cut(s) | 13, 647, 925, 1515, 1636, 1706 |
| AjnI | CCWGG | 5 cut(s) | 154, 1067, 1101, 1947, 2359 |
| AjuI | GAANNNNNNNTTGG | 4 cut(s) | 459, 491, 1527, 1559 |
| AloI | GAACNNNNNNTCC | 2 cut(s) | 2367, 2399 |
| Alw21I | GWGCWC | 2 cut(s) | 530, 2426 |
| Alw26I | GTCTC | 4 cut(s) | 200, 361, 517, 986 |
| AlwI | GGATC | 2 cut(s) | 530, 1259 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 2393 |
| Ama87I | CYCGRG | 1 cut(s) | 1833 |
| Aor13HI | TCCGGA | 1 cut(s) | 2234 |
| AoxI | GGCC | 3 cut(s) | 1799, 1945, 2260 |
| ApeKI | GCWGC | 4 cut(s) | 1008, 1173, 1250, 1518 |
| ApoI | RAATTY | 6 cut(s) | 484, 1144, 1211, 1311, 1609, 1719 |
| AsiGI | ACCGGT | 1 cut(s) | 741 |
| Asp700I | GAANNNNTTC | 2 cut(s) | 1123, 1719 |
| AspS9I | GGNCC | 4 cut(s) | 1547, 1800, 2260, 2379 |
| AsuHPI | GGTGA | 4 cut(s) | 1207, 1544, 1979, 2129 |
| AsuNHI | GCTAGC | 2 cut(s) | 1303, 1895 |
| AvaI | CYCGRG | 1 cut(s) | 1833 |
| AvaII | GGWCC | 2 cut(s) | 1547, 2379 |
| BbsI | GAAGAC | 4 cut(s) | 1452, 1461, 1986, 2243 |
| Bbv12I | GWGCWC | 2 cut(s) | 530, 2426 |
| BbvI | GCAGC | 4 cut(s) | 1020, 1160, 1237, 1530 |
| BccI | CCATC | 7 cut(s) | 95, 389, 559, 1013, 1860, 2033, 2148 |
| BceAI | ACGGC | 1 cut(s) | 1259 |
| BciT130I | CCWGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| BciVI | GTATCC | 1 cut(s) | 562 |
| BclI | TGATCA | 3 cut(s) | 274, 1771, 1969 |
| BcoDI | GTCTC | 4 cut(s) | 200, 361, 517, 986 |
| BfmI | CTRYAG | 2 cut(s) | 1014, 1269 |
| BfuAI | ACCTGC | 1 cut(s) | 113 |
| BfuI | GTATCC | 1 cut(s) | 562 |
| BisI | GCNGC | 4 cut(s) | 1009, 1174, 1251, 1519 |
| BlpI | GCTNAGC | 1 cut(s) | 2425 |
| BlsI | GCNGC | 4 cut(s) | 1010, 1175, 1252, 1520 |
| Bme1390I | CCNGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| Bme18I | GGWCC | 2 cut(s) | 1547, 2379 |
| BmeT110I | CYCGRG | 1 cut(s) | 1833 |
| BmgT120I | GGNCC | 4 cut(s) | 1547, 1800, 2260, 2379 |
| BmiI | GGNNCC | 3 cut(s) | 1193, 1402, 2022 |
| BmrFI | CCNGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| BmrI | ACTGGG | 1 cut(s) | 149 |
| BmsI | GCATC | 2 cut(s) | 1262, 1678 |
| BmtI | GCTAGC | 2 cut(s) | 1307, 1899 |
| BmuI | ACTGGG | 1 cut(s) | 149 |
| BpiI | GAAGAC | 4 cut(s) | 1452, 1461, 1986, 2243 |
| Bpu1102I | GCTNAGC | 1 cut(s) | 2425 |
| BpuEI | CTTGAG | 3 cut(s) | 528, 1076, 1212 |
| BsaAI | YACGTR | 1 cut(s) | 815 |
| BsaBI | GATNNNNATC | 1 cut(s) | 2139 |
| BsaJI | CCNNGG | 2 cut(s) | 1102, 1438 |
| BsaWI | WCCGGW | 2 cut(s) | 741, 2234 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 273, 303 |
| Bsc4I | CCNNNNNNNGG | 1 cut(s) | 545 |
| Bse118I | RCCGGY | 1 cut(s) | 741 |
| Bse1I | ACTGG | 9 cut(s) | 144, 353, 499, 658, 677, 1802, 2202, 2377, 2387 |
| Bse3DI | GCAATG | 1 cut(s) | 780 |
| Bse8I | GATNNNNATC | 1 cut(s) | 2139 |
| BseAI | TCCGGA | 1 cut(s) | 2234 |
| BseBI | CCWGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| BseDI | CCNNGG | 2 cut(s) | 1102, 1438 |
| BseGI | GGATG | 6 cut(s) | 323, 570, 715, 986, 2128, 2231 |
| BseJI | GATNNNNATC | 1 cut(s) | 2139 |
| BseLI | CCNNNNNNNGG | 1 cut(s) | 545 |
| BseMI | GCAATG | 1 cut(s) | 780 |
| BseMII | CTCAG | 4 cut(s) | 195, 854, 1402, 2439 |
| BseNI | ACTGG | 9 cut(s) | 144, 353, 499, 658, 677, 1802, 2202, 2377, 2387 |
| BseRI | GAGGAG | 3 cut(s) | 538, 725, 1590 |
| BseXI | GCAGC | 4 cut(s) | 1020, 1160, 1237, 1530 |
| BseYI | CCCAGC | 1 cut(s) | 1528 |
| BshFI | GGCC | 3 cut(s) | 1801, 1947, 2262 |
| BshTI | ACCGGT | 1 cut(s) | 741 |
| BsiHKAI | GWGCWC | 2 cut(s) | 530, 2426 |
| BsiHKCI | CYCGRG | 1 cut(s) | 1833 |
| BsiSI | CCGG | 3 cut(s) | 539, 742, 2235 |
| BslFI | GGGAC | 1 cut(s) | 643 |
| BslI | CCNNNNNNNGG | 1 cut(s) | 545 |
| BsmAI | GTCTC | 4 cut(s) | 200, 361, 517, 986 |
| BsmFI | GGGAC | 1 cut(s) | 643 |
| BsmI | GAATGC | 2 cut(s) | 1350, 1701 |
| BsnI | GGCC | 3 cut(s) | 1801, 1947, 2262 |
| BsoBI | CYCGRG | 1 cut(s) | 1833 |
| Bsp1286I | GDGCHC | 2 cut(s) | 530, 2426 |
| Bsp13I | TCCGGA | 1 cut(s) | 2234 |
| Bsp1407I | TGTACA | 2 cut(s) | 914, 1554 |
| Bsp143I | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| Bsp1720I | GCTNAGC | 1 cut(s) | 2425 |
| BspACI | CCGC | 2 cut(s) | 342, 683 |
| BspANI | GGCC | 3 cut(s) | 1801, 1947, 2262 |
| BspCNI | CTCAG | 4 cut(s) | 196, 853, 1401, 2438 |
| BspEI | TCCGGA | 1 cut(s) | 2234 |
| BspLI | GGNNCC | 3 cut(s) | 1193, 1402, 2022 |
| BspMI | ACCTGC | 1 cut(s) | 113 |
| BspOI | GCTAGC | 2 cut(s) | 1307, 1899 |
| BspPI | GGATC | 2 cut(s) | 530, 1259 |
| BsrDI | GCAATG | 1 cut(s) | 780 |
| BsrFI | RCCGGY | 1 cut(s) | 741 |
| BsrGI | TGTACA | 2 cut(s) | 914, 1554 |
| BsrI | ACTGG | 9 cut(s) | 144, 353, 499, 658, 677, 1802, 2202, 2377, 2387 |
| BssAI | RCCGGY | 1 cut(s) | 741 |
| BssECI | CCNNGG | 2 cut(s) | 1102, 1438 |
| BssMI | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| Bst2UI | CCWGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| Bst4CI | ACNGT | 8 cut(s) | 211, 316, 789, 1037, 1124, 1439, 1985, 2383 |
| Bst6I | CTCTTC | 1 cut(s) | 1373 |
| BstAUI | TGTACA | 2 cut(s) | 914, 1554 |
| BstBAI | YACGTR | 1 cut(s) | 815 |
| BstC8I | GCNNGC | 6 cut(s) | 461, 1006, 1178, 1248, 1305, 1897 |
| BstDEI | CTNAG | 6 cut(s) | 50, 204, 705, 840, 1388, 2425 |
| BstDSI | CCRYGG | 1 cut(s) | 1438 |
| BstF5I | GGATG | 6 cut(s) | 323, 570, 715, 986, 2128, 2231 |
| BstKTI | GATC | 8 cut(s) | 277, 538, 850, 1267, 1320, 1774, 1972, 2137 |
| BstMAI | GTCTC | 4 cut(s) | 200, 361, 517, 986 |
| BstMBI | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 309, 1290, 1798, 2356 |
| BstNI | CCWGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| BstNSI | RCATGY | 5 cut(s) | 921, 1741, 1809, 2162, 2305 |
| BstSCI | CCNGG | 5 cut(s) | 154, 1067, 1101, 1947, 2359 |
| BstSFI | CTRYAG | 2 cut(s) | 1014, 1269 |
| BstV1I | GCAGC | 4 cut(s) | 1020, 1160, 1237, 1530 |
| BstV2I | GAAGAC | 4 cut(s) | 1452, 1461, 1986, 2243 |
| BstX2I | RGATCY | 2 cut(s) | 535, 1264 |
| BstYI | RGATCY | 2 cut(s) | 535, 1264 |
| BsuI | GTATCC | 1 cut(s) | 562 |
| BsuRI | GGCC | 3 cut(s) | 1801, 1947, 2262 |
| BtgI | CCRYGG | 1 cut(s) | 1438 |
| BtsCI | GGATG | 6 cut(s) | 323, 570, 715, 986, 2128, 2231 |
| BtsIMutI | CAGTG | 5 cut(s) | 270, 312, 794, 857, 2370 |
| BveI | ACCTGC | 1 cut(s) | 113 |
| Cac8I | GCNNGC | 6 cut(s) | 461, 1006, 1178, 1248, 1305, 1897 |
| CaiI | CAGNNNCTG | 1 cut(s) | 2393 |
| Cfr10I | RCCGGY | 1 cut(s) | 741 |
| Cfr13I | GGNCC | 4 cut(s) | 1547, 1800, 2260, 2379 |
| CpoI | CGGWCCG | 1 cut(s) | 2379 |
| Csp6I | GTAC | 8 cut(s) | 190, 727, 915, 935, 1033, 1555, 1986, 2084 |
| CspAI | ACCGGT | 1 cut(s) | 741 |
| CspCI | CAANNNNNGTGG | 2 cut(s) | 1977, 2012 |
| CspI | CGGWCCG | 1 cut(s) | 2379 |
| CviQI | GTAC | 8 cut(s) | 190, 727, 915, 935, 1033, 1555, 1986, 2084 |
| DdeI | CTNAG | 6 cut(s) | 50, 204, 705, 840, 1388, 2425 |
| DpnI | GATC | 8 cut(s) | 276, 537, 849, 1266, 1319, 1773, 1971, 2136 |
| DpnII | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| DraI | TTTAAA | 2 cut(s) | 264, 1045 |
| DrdI | GACNNNNNNGTC | 1 cut(s) | 970 |
| DseDI | GACNNNNNNGTC | 1 cut(s) | 970 |
| Eam1104I | CTCTTC | 1 cut(s) | 1373 |
| EarI | CTCTTC | 1 cut(s) | 1373 |
| Eco32I | GATATC | 1 cut(s) | 659 |
| Eco47I | GGWCC | 2 cut(s) | 1547, 2379 |
| Eco57I | CTGAAG | 2 cut(s) | 1649, 2307 |
| Eco88I | CYCGRG | 1 cut(s) | 1833 |
| EcoRI | GAATTC | 2 cut(s) | 1211, 1311 |
| EcoRII | CCWGG | 5 cut(s) | 154, 1067, 1101, 1947, 2359 |
| EcoRV | GATATC | 1 cut(s) | 659 |
| EcoT22I | ATGCAT | 1 cut(s) | 2164 |
| FaqI | GGGAC | 1 cut(s) | 643 |
| FauNDI | CATATG | 3 cut(s) | 775, 1138, 2008 |
| FbaI | TGATCA | 3 cut(s) | 274, 1771, 1969 |
| Fnu4HI | GCNGC | 4 cut(s) | 1009, 1174, 1251, 1519 |
| FokI | GGATG | 6 cut(s) | 310, 577, 722, 993, 2115, 2218 |
| Fsp4HI | GCNGC | 4 cut(s) | 1009, 1174, 1251, 1519 |
| GluI | GCNGC | 4 cut(s) | 1009, 1174, 1251, 1519 |
| GsaI | CCCAGC | 1 cut(s) | 1532 |
| HaeIII | GGCC | 3 cut(s) | 1801, 1947, 2262 |
| HapII | CCGG | 3 cut(s) | 539, 742, 2235 |
| HincII | GTYRAC | 1 cut(s) | 702 |
| HindII | GTYRAC | 1 cut(s) | 702 |
| HindIII | AAGCTT | 3 cut(s) | 473, 1685, 1750 |
| HpaII | CCGG | 3 cut(s) | 539, 742, 2235 |
| HphI | GGTGA | 4 cut(s) | 1207, 1544, 1979, 2129 |
| Hpy166II | GTNNAC | 4 cut(s) | 192, 702, 729, 1555 |
| Hpy188I | TCNGA | 8 cut(s) | 948, 1222, 1258, 1317, 1391, 1674, 1939, 2062 |
| Hpy8I | GTNNAC | 4 cut(s) | 192, 702, 729, 1555 |
| HpyAV | CCTTC | 8 cut(s) | 55, 302, 595, 1154, 1419, 1529, 1885, 2159 |
| HpyCH4III | ACNGT | 8 cut(s) | 211, 316, 789, 1037, 1124, 1439, 1985, 2383 |
| HpyCH4IV | ACGT | 2 cut(s) | 814, 2210 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 309, 1290, 1798, 2356 |
| HpyF3I | CTNAG | 6 cut(s) | 50, 204, 705, 840, 1388, 2425 |
| HpySE526I | ACGT | 2 cut(s) | 814, 2210 |
| Kpn2I | TCCGGA | 1 cut(s) | 2234 |
| Ksp22I | TGATCA | 3 cut(s) | 274, 1771, 1969 |
| Kzo9I | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| LmnI | GCTCC | 4 cut(s) | 525, 605, 1400, 2026 |
| Lsp1109I | GCAGC | 4 cut(s) | 1020, 1160, 1237, 1530 |
| LweI | GCATC | 2 cut(s) | 1262, 1678 |
| MaeII | ACGT | 2 cut(s) | 814, 2210 |
| MaeIII | GTNAC | 7 cut(s) | 268, 490, 899, 1037, 2206, 2389, 2414 |
| MalI | GATC | 8 cut(s) | 276, 537, 849, 1266, 1319, 1773, 1971, 2136 |
| MboI | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| MflI | RGATCY | 2 cut(s) | 535, 1264 |
| MhlI | GDGCHC | 2 cut(s) | 530, 2426 |
| MlyI | GAGTC | 4 cut(s) | 65, 988, 1853, 2170 |
| MmeI | TCCRAC | 2 cut(s) | 107, 461 |
| Mph1103I | ATGCAT | 1 cut(s) | 2164 |
| MroI | TCCGGA | 1 cut(s) | 2234 |
| MroXI | GAANNNNTTC | 2 cut(s) | 1123, 1719 |
| MspI | CCGG | 3 cut(s) | 539, 742, 2235 |
| MspR9I | CCNGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| Mva1269I | GAATGC | 2 cut(s) | 1350, 1701 |
| MvaI | CCWGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 309, 1290, 1798, 2356 |
| NdeI | CATATG | 3 cut(s) | 775, 1138, 2008 |
| NdeII | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| NheI | GCTAGC | 2 cut(s) | 1303, 1895 |
| NlaIV | GGNNCC | 3 cut(s) | 1193, 1402, 2022 |
| NmuCI | GTSAC | 3 cut(s) | 268, 2206, 2414 |
| NsiI | ATGCAT | 1 cut(s) | 2164 |
| NspI | RCATGY | 5 cut(s) | 921, 1741, 1809, 2162, 2305 |
| PaeR7I | CTCGAG | 1 cut(s) | 1833 |
| PaqCI | CACCTGC | 1 cut(s) | 113 |
| PctI | GAATGC | 2 cut(s) | 1350, 1701 |
| PdmI | GAANNNNTTC | 2 cut(s) | 1123, 1719 |
| PfeI | GAWTC | 9 cut(s) | 144, 248, 349, 371, 1223, 1675, 2219, 2396, 2456 |
| PinAI | ACCGGT | 1 cut(s) | 741 |
| PkrI | GCNGC | 4 cut(s) | 1010, 1175, 1252, 1520 |
| PleI | GAGTC | 4 cut(s) | 65, 988, 1853, 2170 |
| PpsI | GAGTC | 4 cut(s) | 65, 988, 1853, 2170 |
| Ppu21I | YACGTR | 1 cut(s) | 815 |
| Psp6I | CCWGG | 5 cut(s) | 154, 1067, 1101, 1947, 2359 |
| PspFI | CCCAGC | 1 cut(s) | 1528 |
| PspGI | CCWGG | 5 cut(s) | 154, 1067, 1101, 1947, 2359 |
| PspN4I | GGNNCC | 3 cut(s) | 1193, 1402, 2022 |
| PspPI | GGNCC | 4 cut(s) | 1547, 1800, 2260, 2379 |
| PspXI | VCTCGAGB | 1 cut(s) | 1833 |
| PsrI | GAACNNNNNNTAC | 2 cut(s) | 46, 78 |
| PstNI | CAGNNNCTG | 1 cut(s) | 2393 |
| PsuI | RGATCY | 2 cut(s) | 535, 1264 |
| RsaI | GTAC | 8 cut(s) | 191, 728, 916, 936, 1034, 1556, 1987, 2085 |
| RsaNI | GTAC | 8 cut(s) | 190, 727, 915, 935, 1033, 1555, 1986, 2084 |
| Rsr2I | CGGWCCG | 1 cut(s) | 2379 |
| RsrII | CGGWCCG | 1 cut(s) | 2379 |
| SatI | GCNGC | 4 cut(s) | 1009, 1174, 1251, 1519 |
| Sau3AI | GATC | 8 cut(s) | 274, 535, 847, 1264, 1317, 1771, 1969, 2134 |
| Sau96I | GGNCC | 4 cut(s) | 1547, 1800, 2260, 2379 |
| SchI | GAGTC | 4 cut(s) | 65, 988, 1853, 2170 |
| ScrFI | CCNGG | 5 cut(s) | 156, 1069, 1103, 1949, 2361 |
| SduI | GDGCHC | 2 cut(s) | 530, 2426 |
| SfaNI | GCATC | 2 cut(s) | 1262, 1678 |
| SfcI | CTRYAG | 2 cut(s) | 1014, 1269 |
| Sfr274I | CTCGAG | 1 cut(s) | 1833 |
| SinI | GGWCC | 2 cut(s) | 1547, 2379 |
| SlaI | CTCGAG | 1 cut(s) | 1833 |
| SmlI | CTYRAG | 4 cut(s) | 543, 1091, 1227, 1833 |
| SmoI | CTYRAG | 4 cut(s) | 543, 1091, 1227, 1833 |
| SsiI | CCGC | 2 cut(s) | 342, 683 |
| StyD4I | CCNGG | 5 cut(s) | 154, 1067, 1101, 1947, 2359 |
| TaaI | ACNGT | 8 cut(s) | 211, 316, 789, 1037, 1124, 1439, 1985, 2383 |
| TaiI | ACGT | 2 cut(s) | 817, 2213 |
| TaqI | TCGA | 3 cut(s) | 962, 1794, 1834 |
| TatI | WGTACW | 6 cut(s) | 726, 914, 1032, 1554, 1985, 2083 |
| TfiI | GAWTC | 9 cut(s) | 144, 248, 349, 371, 1223, 1675, 2219, 2396, 2456 |
| TscAI | CASTG | 5 cut(s) | 277, 319, 794, 857, 2377 |
| TseFI | GTSAC | 3 cut(s) | 268, 2206, 2414 |
| TseI | GCWGC | 4 cut(s) | 1008, 1173, 1250, 1518 |
| Tsp45I | GTSAC | 3 cut(s) | 268, 2206, 2414 |
| TspGWI | ACGGA | 3 cut(s) | 577, 1390, 2392 |
| TspRI | CASTG | 5 cut(s) | 277, 319, 794, 857, 2377 |
| VpaK11BI | GGWCC | 2 cut(s) | 1547, 2379 |
| XapI | RAATTY | 6 cut(s) | 484, 1144, 1211, 1311, 1609, 1719 |
| XbaI | TCTAGA | 1 cut(s) | 1862 |
| XceI | RCATGY | 5 cut(s) | 921, 1741, 1809, 2162, 2305 |
| XcmI | CCANNNNNNNNNTGG | 1 cut(s) | 1411 |
| XhoI | CTCGAG | 1 cut(s) | 1833 |
| XmnI | GAANNNNTTC | 2 cut(s) | 1123, 1719 |
| Zsp2I | ATGCAT | 1 cut(s) | 2164 |