Domain of unknown function (DUF4283)
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| DUF4283 | PF14111 | 69 - 148 | 6.2e-06 | Domain of unknown function (DUF4283) |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AarI | CACCTGC | 1 cut(s) | 1190 |
| Acc36I | ACCTGC | 2 cut(s) | 127, 1190 |
| AccI | GTMKAC | 1 cut(s) | 217 |
| AccII | CGCG | 1 cut(s) | 135 |
| AciI | CCGC | 7 cut(s) | 29, 47, 135, 314, 1046, 1387, 1443 |
| AclWI | GGATC | 3 cut(s) | 633, 942, 1440 |
| AcoI | YGGCCR | 2 cut(s) | 730, 1228 |
| AcsI | RAATTY | 3 cut(s) | 609, 703, 1312 |
| AcyI | GRCGYC | 1 cut(s) | 304 |
| AdeI | CACNNNGTG | 1 cut(s) | 282 |
| AfaI | GTAC | 3 cut(s) | 385, 712, 836 |
| AfiI | CCNNNNNNNGG | 4 cut(s) | 1284, 1285, 1286, 1421 |
| AflII | CTTAAG | 1 cut(s) | 1340 |
| AgsI | TTSAA | 9 cut(s) | 87, 92, 187, 196, 247, 689, 1040, 1112, 1298 |
| AhlI | ACTAGT | 1 cut(s) | 1223 |
| AjnI | CCWGG | 1 cut(s) | 632 |
| AluBI | AGCT | 4 cut(s) | 38, 296, 1143, 1471 |
| AluI | AGCT | 4 cut(s) | 38, 296, 1143, 1471 |
| Alw21I | GWGCWC | 1 cut(s) | 1145 |
| Alw26I | GTCTC | 4 cut(s) | 108, 441, 1058, 1375 |
| AlwI | GGATC | 3 cut(s) | 633, 942, 1440 |
| AoxI | GGCC | 3 cut(s) | 730, 1228, 1336 |
| ApeKI | GCWGC | 2 cut(s) | 944, 1196 |
| ApoI | RAATTY | 3 cut(s) | 609, 703, 1312 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 326, 358 |
| Asp700I | GAANNNNTTC | 3 cut(s) | 62, 191, 1164 |
| AspA2I | CCTAGG | 2 cut(s) | 977, 1283 |
| AspS9I | GGNCC | 3 cut(s) | 481, 982, 1457 |
| AsuC2I | CCSGG | 2 cut(s) | 444, 572 |
| AsuHPI | GGTGA | 2 cut(s) | 1214, 1340 |
| AvaII | GGWCC | 3 cut(s) | 481, 982, 1457 |
| AvrII | CCTAGG | 2 cut(s) | 977, 1283 |
| BaeGI | GKGCMC | 2 cut(s) | 554, 1427 |
| BalI | TGGCCA | 2 cut(s) | 732, 1230 |
| BanII | GRGCYC | 1 cut(s) | 1145 |
| BbsI | GAAGAC | 2 cut(s) | 254, 1254 |
| Bbv12I | GWGCWC | 1 cut(s) | 1145 |
| BbvCI | CCTCAGC | 1 cut(s) | 292 |
| BbvI | GCAGC | 2 cut(s) | 931, 1208 |
| BccI | CCATC | 4 cut(s) | 652, 880, 1265, 1315 |
| BciT130I | CCWGG | 1 cut(s) | 634 |
| BciVI | GTATCC | 1 cut(s) | 320 |
| BcnI | CCSGG | 2 cut(s) | 444, 572 |
| BcoDI | GTCTC | 4 cut(s) | 108, 441, 1058, 1375 |
| BcuI | ACTAGT | 1 cut(s) | 1223 |
| BfaI | CTAG | 3 cut(s) | 978, 1224, 1284 |
| BfmI | CTRYAG | 1 cut(s) | 819 |
| BfrI | CTTAAG | 1 cut(s) | 1340 |
| BfuAI | ACCTGC | 2 cut(s) | 127, 1190 |
| BfuI | GTATCC | 1 cut(s) | 320 |
| BisI | GCNGC | 3 cut(s) | 945, 1047, 1197 |
| BlnI | CCTAGG | 2 cut(s) | 977, 1283 |
| BlsI | GCNGC | 3 cut(s) | 946, 1048, 1198 |
| Bme1390I | CCNGG | 3 cut(s) | 444, 572, 634 |
| Bme18I | GGWCC | 3 cut(s) | 481, 982, 1457 |
| BmgT120I | GGNCC | 3 cut(s) | 481, 982, 1457 |
| BmiI | GGNNCC | 6 cut(s) | 8, 482, 983, 1092, 1276, 1458 |
| BmrFI | CCNGG | 3 cut(s) | 444, 572, 634 |
| BmsI | GCATC | 2 cut(s) | 77, 523 |
| BpiI | GAAGAC | 2 cut(s) | 254, 1254 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 438, 470 |
| Bpu10I | CCTNAGC | 1 cut(s) | 292 |
| BpuEI | CTTGAG | 3 cut(s) | 245, 1159, 1190 |
| BpuMI | CCSGG | 2 cut(s) | 444, 572 |
| BsaBI | GATNNNNATC | 1 cut(s) | 624 |
| BsaHI | GRCGYC | 1 cut(s) | 304 |
| BsaJI | CCNNGG | 6 cut(s) | 51, 208, 299, 633, 977, 1283 |
| BsaXI | ACNNNNNCTCC | 8 cut(s) | 10, 25, 40, 55, 575, 605, 1127, 1157 |
| Bsc4I | CCNNNNNNNGG | 4 cut(s) | 1284, 1285, 1286, 1421 |
| Bse1I | ACTGG | 2 cut(s) | 406, 1267 |
| Bse3DI | GCAATG | 1 cut(s) | 557 |
| Bse8I | GATNNNNATC | 1 cut(s) | 624 |
| BseBI | CCWGG | 1 cut(s) | 634 |
| BseDI | CCNNGG | 6 cut(s) | 51, 208, 299, 633, 977, 1283 |
| BseGI | GGATG | 4 cut(s) | 361, 514, 1060, 1138 |
| BseJI | GATNNNNATC | 1 cut(s) | 624 |
| BseLI | CCNNNNNNNGG | 4 cut(s) | 1284, 1285, 1286, 1421 |
| BseMI | GCAATG | 1 cut(s) | 557 |
| BseMII | CTCAG | 6 cut(s) | 306, 818, 1031, 1161, 1199, 1233 |
| BseNI | ACTGG | 2 cut(s) | 406, 1267 |
| BseRI | GAGGAG | 6 cut(s) | 15, 30, 33, 1103, 1135, 1187 |
| BseSI | GKGCMC | 2 cut(s) | 554, 1427 |
| BseXI | GCAGC | 2 cut(s) | 931, 1208 |
| BseYI | CCCAGC | 2 cut(s) | 316, 1074 |
| BsgI | GTGCAG | 2 cut(s) | 105, 222 |
| Bsh1236I | CGCG | 1 cut(s) | 135 |
| BshFI | GGCC | 3 cut(s) | 732, 1230, 1338 |
| BsiHKAI | GWGCWC | 1 cut(s) | 1145 |
| BsiSI | CCGG | 2 cut(s) | 443, 571 |
| BslI | CCNNNNNNNGG | 4 cut(s) | 1284, 1285, 1286, 1421 |
| BsmAI | GTCTC | 4 cut(s) | 108, 441, 1058, 1375 |
| BsmBI | CGTCTC | 1 cut(s) | 441 |
| BsnI | GGCC | 3 cut(s) | 732, 1230, 1338 |
| Bsp1286I | GDGCHC | 3 cut(s) | 554, 1145, 1427 |
| Bsp143I | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| Bsp19I | CCATGG | 1 cut(s) | 299 |
| BspACI | CCGC | 7 cut(s) | 29, 47, 135, 314, 1046, 1387, 1443 |
| BspANI | GGCC | 3 cut(s) | 732, 1230, 1338 |
| BspCNI | CTCAG | 6 cut(s) | 305, 817, 1030, 1160, 1198, 1234 |
| BspFNI | CGCG | 1 cut(s) | 135 |
| BspLI | GGNNCC | 6 cut(s) | 8, 482, 983, 1092, 1276, 1458 |
| BspMI | ACCTGC | 2 cut(s) | 127, 1190 |
| BspPI | GGATC | 3 cut(s) | 633, 942, 1440 |
| BspTI | CTTAAG | 1 cut(s) | 1340 |
| BsrDI | GCAATG | 1 cut(s) | 557 |
| BsrI | ACTGG | 2 cut(s) | 406, 1267 |
| BssECI | CCNNGG | 6 cut(s) | 51, 208, 299, 633, 977, 1283 |
| BssMI | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| BssNI | GRCGYC | 1 cut(s) | 304 |
| BssT1I | CCWWGG | 5 cut(s) | 51, 208, 299, 977, 1283 |
| Bst2UI | CCWGG | 1 cut(s) | 634 |
| Bst4CI | ACNGT | 4 cut(s) | 820, 961, 1033, 1429 |
| Bst6I | CTCTTC | 2 cut(s) | 1035, 1413 |
| BstACI | GRCGYC | 1 cut(s) | 304 |
| BstAFI | CTTAAG | 1 cut(s) | 1340 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 880 |
| BstC8I | GCNNGC | 1 cut(s) | 1305 |
| BstDEI | CTNAG | 8 cut(s) | 107, 292, 365, 804, 1017, 1147, 1185, 1242 |
| BstDSI | CCRYGG | 1 cut(s) | 299 |
| BstF5I | GGATG | 4 cut(s) | 361, 514, 1060, 1138 |
| BstFNI | CGCG | 1 cut(s) | 135 |
| BstKTI | GATC | 7 cut(s) | 159, 259, 628, 660, 745, 937, 1435 |
| BstMAI | GTCTC | 4 cut(s) | 108, 441, 1058, 1375 |
| BstMBI | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 796, 805, 880, 1022 |
| BstNI | CCWGG | 1 cut(s) | 634 |
| BstNSI | RCATGY | 2 cut(s) | 390, 944 |
| BstSCI | CCNGG | 3 cut(s) | 442, 570, 632 |
| BstSFI | CTRYAG | 1 cut(s) | 819 |
| BstSLI | GKGCMC | 2 cut(s) | 554, 1427 |
| BstUI | CGCG | 1 cut(s) | 135 |
| BstV1I | GCAGC | 2 cut(s) | 931, 1208 |
| BstV2I | GAAGAC | 2 cut(s) | 254, 1254 |
| BstX2I | RGATCY | 1 cut(s) | 625 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 691 |
| BstYI | RGATCY | 1 cut(s) | 625 |
| BsuI | GTATCC | 1 cut(s) | 320 |
| BsuRI | GGCC | 3 cut(s) | 732, 1230, 1338 |
| BtgI | CCRYGG | 1 cut(s) | 299 |
| BtsCI | GGATG | 4 cut(s) | 361, 514, 1060, 1138 |
| BtsI | GCAGTG | 1 cut(s) | 1314 |
| BtsIMutI | CAGTG | 3 cut(s) | 1239, 1314, 1425 |
| BveI | ACCTGC | 2 cut(s) | 127, 1190 |
| Cac8I | GCNNGC | 1 cut(s) | 1305 |
| Cfr13I | GGNCC | 3 cut(s) | 481, 982, 1457 |
| CseI | GACGC | 2 cut(s) | 293, 815 |
| Csp6I | GTAC | 3 cut(s) | 384, 711, 835 |
| CviAII | CATG | 7 cut(s) | 300, 387, 467, 542, 875, 941, 1232 |
| CviQI | GTAC | 3 cut(s) | 384, 711, 835 |
| DdeI | CTNAG | 8 cut(s) | 107, 292, 365, 804, 1017, 1147, 1185, 1242 |
| DpnI | GATC | 7 cut(s) | 158, 258, 627, 659, 744, 936, 1434 |
| DpnII | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| DraIII | CACNNNGTG | 1 cut(s) | 282 |
| EaeI | YGGCCR | 2 cut(s) | 730, 1228 |
| Eam1104I | CTCTTC | 2 cut(s) | 1035, 1413 |
| EarI | CTCTTC | 2 cut(s) | 1035, 1413 |
| EciI | GGCGGA | 2 cut(s) | 18, 36 |
| Ecl136II | GAGCTC | 1 cut(s) | 1143 |
| Eco130I | CCWWGG | 5 cut(s) | 51, 208, 299, 977, 1283 |
| Eco147I | AGGCCT | 1 cut(s) | 1338 |
| Eco24I | GRGCYC | 1 cut(s) | 1145 |
| Eco47I | GGWCC | 3 cut(s) | 481, 982, 1457 |
| Eco53kI | GAGCTC | 1 cut(s) | 1143 |
| EcoICRI | GAGCTC | 1 cut(s) | 1143 |
| EcoRI | GAATTC | 1 cut(s) | 1312 |
| EcoRII | CCWGG | 1 cut(s) | 632 |
| EcoT14I | CCWWGG | 5 cut(s) | 51, 208, 299, 977, 1283 |
| EcoT38I | GRGCYC | 1 cut(s) | 1145 |
| ErhI | CCWWGG | 5 cut(s) | 51, 208, 299, 977, 1283 |
| Esp3I | CGTCTC | 1 cut(s) | 441 |
| FaeI | CATG | 7 cut(s) | 303, 390, 470, 545, 878, 944, 1235 |
| FatI | CATG | 7 cut(s) | 299, 386, 466, 541, 874, 940, 1231 |
| FauI | CCCGC | 1 cut(s) | 1450 |
| FblI | GTMKAC | 1 cut(s) | 217 |
| Fnu4HI | GCNGC | 3 cut(s) | 945, 1047, 1197 |
| FokI | GGATG | 4 cut(s) | 368, 501, 1067, 1145 |
| FriOI | GRGCYC | 1 cut(s) | 1145 |
| Fsp4HI | GCNGC | 3 cut(s) | 945, 1047, 1197 |
| FspBI | CTAG | 3 cut(s) | 978, 1224, 1284 |
| GluI | GCNGC | 3 cut(s) | 945, 1047, 1197 |
| GsaI | CCCAGC | 2 cut(s) | 320, 1078 |
| HaeIII | GGCC | 3 cut(s) | 732, 1230, 1338 |
| HapII | CCGG | 2 cut(s) | 443, 571 |
| HgaI | GACGC | 2 cut(s) | 293, 815 |
| Hin1I | GRCGYC | 1 cut(s) | 304 |
| Hin1II | CATG | 7 cut(s) | 303, 390, 470, 545, 878, 944, 1235 |
| HincII | GTYRAC | 1 cut(s) | 1209 |
| HindII | GTYRAC | 1 cut(s) | 1209 |
| HindIII | AAGCTT | 1 cut(s) | 1469 |
| HinfI | GANTC | 5 cut(s) | 14, 83, 92, 971, 1383 |
| HpaII | CCGG | 2 cut(s) | 443, 571 |
| HphI | GGTGA | 2 cut(s) | 1214, 1340 |
| Hpy166II | GTNNAC | 4 cut(s) | 218, 711, 1209, 1460 |
| Hpy188I | TCNGA | 7 cut(s) | 82, 413, 485, 865, 957, 994, 1150 |
| Hpy188III | TCNNGA | 6 cut(s) | 154, 176, 830, 1157, 1169, 1187 |
| Hpy8I | GTNNAC | 4 cut(s) | 218, 711, 1209, 1460 |
| HpyAV | CCTTC | 2 cut(s) | 574, 810 |
| HpyCH4III | ACNGT | 4 cut(s) | 820, 961, 1033, 1429 |
| HpyCH4IV | ACGT | 1 cut(s) | 450 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 796, 805, 880, 1022 |
| HpyF3I | CTNAG | 8 cut(s) | 107, 292, 365, 804, 1017, 1147, 1185, 1242 |
| HpySE526I | ACGT | 1 cut(s) | 450 |
| Hsp92I | GRCGYC | 1 cut(s) | 304 |
| Hsp92II | CATG | 7 cut(s) | 303, 390, 470, 545, 878, 944, 1235 |
| Kzo9I | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| LmnI | GCTCC | 9 cut(s) | 43, 178, 228, 301, 583, 952, 1090, 1148, 1174 |
| Lsp1109I | GCAGC | 2 cut(s) | 931, 1208 |
| LweI | GCATC | 2 cut(s) | 77, 523 |
| MaeI | CTAG | 3 cut(s) | 978, 1224, 1284 |
| MaeII | ACGT | 1 cut(s) | 450 |
| MaeIII | GTNAC | 3 cut(s) | 856, 925, 1436 |
| MalI | GATC | 7 cut(s) | 158, 258, 627, 659, 744, 936, 1434 |
| MboI | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| MboII | GAAGA | 6 cut(s) | 259, 639, 981, 1052, 1259, 1430 |
| MfeI | CAATTG | 3 cut(s) | 72, 87, 182 |
| MflI | RGATCY | 1 cut(s) | 625 |
| MhlI | GDGCHC | 3 cut(s) | 554, 1145, 1427 |
| MlsI | TGGCCA | 2 cut(s) | 732, 1230 |
| MluNI | TGGCCA | 2 cut(s) | 732, 1230 |
| MlyI | GAGTC | 3 cut(s) | 8, 965, 1377 |
| MmeI | TCCRAC | 1 cut(s) | 974 |
| Mox20I | TGGCCA | 2 cut(s) | 732, 1230 |
| MroXI | GAANNNNTTC | 3 cut(s) | 62, 191, 1164 |
| MscI | TGGCCA | 2 cut(s) | 732, 1230 |
| MseI | TTAA | 3 cut(s) | 273, 1341, 1473 |
| MslI | CAYNNNNRTG | 1 cut(s) | 689 |
| Msp20I | TGGCCA | 2 cut(s) | 732, 1230 |
| MspA1I | CMGCKG | 1 cut(s) | 316 |
| MspCI | CTTAAG | 1 cut(s) | 1340 |
| MspI | CCGG | 2 cut(s) | 443, 571 |
| MspR9I | CCNGG | 3 cut(s) | 444, 572, 634 |
| MunI | CAATTG | 3 cut(s) | 72, 87, 182 |
| MvaI | CCWGG | 1 cut(s) | 634 |
| MvnI | CGCG | 1 cut(s) | 135 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 796, 805, 880, 1022 |
| NciI | CCSGG | 2 cut(s) | 444, 572 |
| NcoI | CCATGG | 1 cut(s) | 299 |
| NdeII | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| NlaIII | CATG | 7 cut(s) | 303, 390, 470, 545, 878, 944, 1235 |
| NlaIV | GGNNCC | 6 cut(s) | 8, 482, 983, 1092, 1276, 1458 |
| NmuCI | GTSAC | 1 cut(s) | 856 |
| NspI | RCATGY | 2 cut(s) | 390, 944 |
| PaqCI | CACCTGC | 1 cut(s) | 1190 |
| PceI | AGGCCT | 1 cut(s) | 1338 |
| PdmI | GAANNNNTTC | 3 cut(s) | 62, 191, 1164 |
| PfeI | GAWTC | 2 cut(s) | 83, 92 |
| PkrI | GCNGC | 3 cut(s) | 946, 1048, 1198 |
| PleI | GAGTC | 3 cut(s) | 8, 965, 1377 |
| PpsI | GAGTC | 3 cut(s) | 8, 965, 1377 |
| Psp124BI | GAGCTC | 1 cut(s) | 1145 |
| Psp6I | CCWGG | 1 cut(s) | 632 |
| PspFI | CCCAGC | 2 cut(s) | 316, 1074 |
| PspGI | CCWGG | 1 cut(s) | 632 |
| PspN4I | GGNNCC | 6 cut(s) | 8, 482, 983, 1092, 1276, 1458 |
| PspPI | GGNCC | 3 cut(s) | 481, 982, 1457 |
| PsuI | RGATCY | 1 cut(s) | 625 |
| RsaI | GTAC | 3 cut(s) | 385, 712, 836 |
| RsaNI | GTAC | 3 cut(s) | 384, 711, 835 |
| RseI | CAYNNNNRTG | 1 cut(s) | 689 |
| SacI | GAGCTC | 1 cut(s) | 1145 |
| SaqAI | TTAA | 3 cut(s) | 273, 1341, 1473 |
| SatI | GCNGC | 3 cut(s) | 945, 1047, 1197 |
| Sau3AI | GATC | 7 cut(s) | 156, 256, 625, 657, 742, 934, 1432 |
| Sau96I | GGNCC | 3 cut(s) | 481, 982, 1457 |
| SchI | GAGTC | 3 cut(s) | 8, 965, 1377 |
| ScrFI | CCNGG | 3 cut(s) | 444, 572, 634 |
| SduI | GDGCHC | 3 cut(s) | 554, 1145, 1427 |
| SfaNI | GCATC | 2 cut(s) | 77, 523 |
| SfcI | CTRYAG | 1 cut(s) | 819 |
| SinI | GGWCC | 3 cut(s) | 481, 982, 1457 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 689 |
| SmlI | CTYRAG | 4 cut(s) | 260, 1138, 1169, 1340 |
| SmoI | CTYRAG | 4 cut(s) | 260, 1138, 1169, 1340 |
| SpeI | ACTAGT | 1 cut(s) | 1223 |
| SseBI | AGGCCT | 1 cut(s) | 1338 |
| SsiI | CCGC | 7 cut(s) | 29, 47, 135, 314, 1046, 1387, 1443 |
| SspMI | CTAG | 3 cut(s) | 978, 1224, 1284 |
| SstI | GAGCTC | 1 cut(s) | 1145 |
| StuI | AGGCCT | 1 cut(s) | 1338 |
| StyD4I | CCNGG | 3 cut(s) | 442, 570, 632 |
| StyI | CCWWGG | 5 cut(s) | 51, 208, 299, 977, 1283 |
| TaaI | ACNGT | 4 cut(s) | 820, 961, 1033, 1429 |
| TaiI | ACGT | 1 cut(s) | 453 |
| TaqI | TCGA | 3 cut(s) | 17, 333, 660 |
| TatI | WGTACW | 1 cut(s) | 834 |
| TauI | GCSGC | 1 cut(s) | 1049 |
| TfiI | GAWTC | 2 cut(s) | 83, 92 |
| Tru1I | TTAA | 3 cut(s) | 273, 1341, 1473 |
| Tru9I | TTAA | 3 cut(s) | 273, 1341, 1473 |
| TscAI | CASTG | 3 cut(s) | 1246, 1314, 1432 |
| TseFI | GTSAC | 1 cut(s) | 856 |
| TseI | GCWGC | 2 cut(s) | 944, 1196 |
| Tsp45I | GTSAC | 1 cut(s) | 856 |
| TspDTI | ATGAA | 3 cut(s) | 714, 933, 1071 |
| TspGWI | ACGGA | 1 cut(s) | 215 |
| TspRI | CASTG | 3 cut(s) | 1246, 1314, 1432 |
| Vha464I | CTTAAG | 1 cut(s) | 1340 |
| VpaK11BI | GGWCC | 3 cut(s) | 481, 982, 1457 |
| XapI | RAATTY | 3 cut(s) | 609, 703, 1312 |
| XceI | RCATGY | 2 cut(s) | 390, 944 |
| XcmI | CCANNNNNNNNNTGG | 1 cut(s) | 1259 |
| XmaJI | CCTAGG | 2 cut(s) | 977, 1283 |
| XmiI | GTMKAC | 1 cut(s) | 217 |
| XmnI | GAANNNNTTC | 3 cut(s) | 62, 191, 1164 |
| XspI | CTAG | 3 cut(s) | 978, 1224, 1284 |